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Results for “Severe Combined Immunodeficiency Disease”

115 trials

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Showing 20 of 115 results

Early research (Phase 1)Study completedNCT02022696
What this trial is testing

Treatment of SCID Due to ADA Deficiency With Autologous Transplantation of Cord Blood or Hematopoietic CD 34+ Cells After Addition of a Normal Human ADA cDNA by the EFS-ADA Lentiviral Vector

Who this might be right for
Adenosine Deaminase DeficiencyADA-SCID
National Human Genome Research Institute (NHGRI) 1
Testing effectiveness (Phase 2)Looking for participantsNCT03538899
What this trial is testing

Autologous Gene Therapy for Artemis-Deficient SCID

Who this might be right for
Severe Combined Immunodeficiency
University of California, San Francisco 24
Testing effectiveness (Phase 2)WithdrawnNCT04370795
What this trial is testing

Matched Related and Unrelated Donor Stem Cell Transplantation for Severe Combined Immune Deficiency (SCID): Busulfan-based Conditioning With h-ATG, Radiation, and Sirolimus

Who this might be right for
Severe Combined Immune Deficiency (SCID)
National Institute of Allergy and Infectious Diseases (NIAID)
Not applicableEnrolling By InvitationNCT00895271
What this trial is testing

Establishing Fibroblast-Derived Cell Lines From Skin Biopsies of Patients With Immunodeficiency or Immunodysregulation Disorders

Who this might be right for
Primary ImmunodeficiencyDOCK8Virus Susceptibility
National Institute of Allergy and Infectious Diseases (NIAID) 200
Not applicableEnrolling By InvitationNCT03655223
What this trial is testing

Early Check: Expanded Screening in Newborns

Who this might be right for
Spinal Muscular AtrophyFragile X SyndromeFragile X - Premutation+182 more
RTI International 30,000
Testing effectiveness (Phase 2)Study completedNCT00794508
What this trial is testing

MND-ADA Transduction of CD34+ Cells From Children With ADA-SCID

Who this might be right for
Severe Combined Immunodeficiency
Donald B. Kohn, M.D. 10
Large-scale testing (Phase 3)Study completedNCT01019876
What this trial is testing

Risk-Adapted Allogeneic Stem Cell Transplantation For Mixed Donor Chimerism In Patients With Non-Malignant Diseases

Who this might be right for
Bone Marrow FailureOsteopetrosisFanconi Anemia+1 more
Columbia University 38
Testing effectiveness (Phase 2)Study completedNCT04996797
What this trial is testing

Safety and Efficacy Study of Tulisokibart (MK-7240/PRA023) in Subjects With Moderately to Severely Active Ulcerative Colitis (MK-7240-005)

Who this might be right for
Ulcerative Colitis
Prometheus Biosciences, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) 178
Testing effectiveness (Phase 2)Study completedNCT01129544
What this trial is testing

Gene Transfer for Severe Combined Immunodeficiency, X-linked (SCID-X1) Using a Self-inactivating (SIN) Gammaretroviral Vector

Who this might be right for
Severe Combined Immunodeficiency
David Williams 8
Testing effectiveness (Phase 2)Ended earlyNCT01182675
What this trial is testing

Hematopoietic Stem Cell Transplantation (HSCT) for Children With SCID Utilizing Alemtuzumab, Plerixafor & Filgrastim

Who this might be right for
Severe Combined Immunodeficiency
University of California, San Francisco 7
Not applicableWithdrawnNCT04331483
What this trial is testing

Assess a Physical Activity Program in Children, Adolescents and Young Adults Requiring Hematopoietic Stem Cell Allografts

Who this might be right for
Haematological MalignancyAcute LeukemiaMyelodysplastic Syndromes+3 more
Centre Leon Berard
Testing effectiveness (Phase 2)Study completedNCT03765632
What this trial is testing

Efficacy and Safety of the Cryopreserved Formulation of OTL-101 in Subjects With ADA-SCID

Who this might be right for
Severe Combined Immunodeficiency Due to ADA Deficiency
Great Ormond Street Hospital for Children NHS Foundation Trust 13
Not applicableStudy completedNCT00845416
What this trial is testing

Newborn Screening for Severe Combined Immunodeficiency (SCID) in a High-Risk Population

Who this might be right for
Severe Combined ImmunodeficiencyT Cell Lymphocytopenia
University of California, San Francisco 1,800
Testing effectiveness (Phase 2)UnknownNCT03315078
What this trial is testing

Lentiviral Gene Transfer for Treatment of Children Older Than 2 Years of Age With X-Linked Severe Combined Immunodeficiency

Who this might be right for
X-Linked Combined Immunodeficiency Diseases
National Institute of Allergy and Infectious Diseases (NIAID) 13
Large-scale testing (Phase 3)Study completedNCT01420627
What this trial is testing

EZN-2279 in Patients With ADA-SCID

Who this might be right for
ADA-SCIDAdenosine Deaminase DeficiencySevere Combined Immunodeficiency
Leadiant Biosciences, Inc. 7
Not applicableUnknownNCT02231983
What this trial is testing

Clinical Characteristics and Genetic Profiles of Severe Combined Immunodeficiency in China

Who this might be right for
Severe Combined Immunodeficiency
Shanghai Children's Medical Center 50
Early research (Phase 1)Ended earlyNCT04409080
What this trial is testing

REGN7257 in Adult Patients With Severe Aplastic Anemia That Is Refractory to or Relapsed on Immunosuppressive Therapy

Who this might be right for
Severe Aplastic Anemia (SAA)
Regeneron Pharmaceuticals 17
Testing effectiveness (Phase 2)Looking for participantsNCT05071222
What this trial is testing

Safety and Efficacy Study of Transplantation of Autologous CD34+ Cells Transduced With the G2ARTE Lentiviral Vector Expressing the DCLRE1C cDNA in Artemis (DCLRE1C) Deficient Severe Combined Immunodeficiency Patients (ARTEGENE)

Who this might be right for
Artemis (DCLRE1C ) Deficient Severe Combined Immunodeficiency
Assistance Publique - Hôpitaux de Paris 7
Testing effectiveness (Phase 2)Study completedNCT00599781
What this trial is testing

Gene Therapy for ADA-SCID

Who this might be right for
Severe Combined Immunodeficiency Syndrome
IRCCS San Raffaele 8
Testing effectiveness (Phase 2)Ended earlyNCT00579137
What this trial is testing

Allogeneic SCT Of Pts With SCID And Other Primary Immunodeficiency Disorders

Who this might be right for
Severe Combined Immunodeficiency DiseaseSevere Primary Immunodeficiency DisorderUndefined T Cell Deficiency Disorder+1 more
Baylor College of Medicine 3
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