Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • About
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Severe Familial Hypercholesterolemia”

9 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 9 of 9 results

Large-scale testing (Phase 3)Study completedNCT01624142
What this trial is testing

Trial Assessing Long Term USe of PCSK9 Inhibition in Subjects With Genetic LDL Disorders

Who this might be right for
Severe Familial Hypercholesterolemia
Amgen 300
Not applicableStudy completedNCT03795038
What this trial is testing

Comparison of the Plasma Lipoprotein Apheresis Systems DIAMED and MONET vs. the Whole Blood Apheresis System DALI

Who this might be right for
Hypercholesterolemia, FamilialDyslipidemiasCardiovascular Diseases
Fresenius Medical Care Deutschland GmbH 20
Not applicableApproved For MarketingNCT06500598
What this trial is testing

Compassionate Use of Evinacumab

Who this might be right for
Pediatric Homozygous Familial Hypercholesterolemia (HoFH)Severe Hypertriglyceridemia (HTG)Dysbetalipoproteinemia (DBL)
Regeneron Pharmaceuticals
Early research (Phase 1)Looking for participantsNCT07491172
What this trial is testing

A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory Dyslipidemias

Who this might be right for
CardiovascularMetabolic DiseaseDyslipidemias+7 more
CRISPR Therapeutics AG 90
Large-scale testing (Phase 3)Study completedNCT02585895
What this trial is testing

Evolocumab Compared to LDL-C Apheresis in Patients Receiving LDL-C Apheresis Prior to Study Enrollment

Who this might be right for
Hypercholesterolemia
Amgen 39
Large-scale testing (Phase 3)Study completedNCT02624869
What this trial is testing

Safety, Tolerability and Efficacy of Evolocumab (AMG 145) in Children With Inherited Elevated Low-density Lipoprotein Cholesterol (Familial Hypercholesterolemia)

Who this might be right for
Familial Hypercholesterolemia
Amgen 163
Large-scale testing (Phase 3)Study completedNCT00694109
What this trial is testing

An Open-label Extension Study to Assess the Long-term Safety and Efficacy of ISIS 301012 (Mipomersen) in Patients With Familial Hypercholesterolemia or Severe-Hypercholesterolemia

Who this might be right for
Lipid Metabolism, Inborn ErrorsHypercholesterolemia, Autosomal DominantHyperlipidemias+11 more
Kastle Therapeutics, LLC 144
Not applicableActive Not RecruitingNCT06832371
What this trial is testing

Evaluation of the Effect of Lomitapide Treatment on Major Adverse Cardiovascular Events (MACE) in Patients With Homozygous Familial Hypercholesterolemia

Who this might be right for
Homozygous Familial Hypercholesterolemia (HoFH)Major Adverse Cardiovascular Events (MACE)Dyslipidemia
Fondazione SISA (Societa Italiana per lo Studio della Arteriosclerosi) 73
Large-scale testing (Phase 3)Study completedNCT01007344
What this trial is testing

Flaxseed Compared With Placebo in Patients With Hypercholesterolemia

Who this might be right for
Familial or Severe Hypercholesterolemia
The Hospital for Sick Children 30