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Results for “Severe Hypercholesterolemia”

32 trials

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Showing 20 of 32 results

Large-scale testing (Phase 3)Study completedNCT02585895
What this trial is testing

Evolocumab Compared to LDL-C Apheresis in Patients Receiving LDL-C Apheresis Prior to Study Enrollment

Who this might be right for
Hypercholesterolemia
Amgen 39
Post-approval studies (Phase 4)Ended earlyNCT02499185
What this trial is testing

Study Evaluating Novel Biomarkers of AKI (Acute Kidney Injury) in Post-operative Patients

Who this might be right for
Acute Kidney InjuryArterial HypertensionObesity+4 more
Universitair Ziekenhuis Brussel 100
Large-scale testing (Phase 3)Study completedNCT00794664
What this trial is testing

Safety and Efficacy of Mipomersen in Patients With Severe Hypercholesterolemia on a Maximally Tolerated Lipid-Lowering Regimen and Who Are Not on Apheresis

Who this might be right for
HypercholesterolemiaCoronary Heart Disease
Kastle Therapeutics, LLC 58
Large-scale testing (Phase 3)Ended earlyNCT00766688
What this trial is testing

Evaluation of Safety and Efficacy of AVE5530 as add-on to Ongoing High Doses of Statins in Patients With Primary Severe Hypercholesterolemia

Who this might be right for
Hypercholesterolemia
Sanofi 643
Not applicableUnknownNCT03428308
What this trial is testing

Detection and Treatment of Somatic Disease in Patients With Severe Mental Disease

Who this might be right for
IschemiaCardiac InsufficiencyDiabetes Mellitus, Type 2+3 more
Intersectoral Research Unit for Health Services 90
Not applicableStudy completedNCT06045377
What this trial is testing

Effect of Armolipid on Lipid Profile in Children With Hypercholesterolemia

Who this might be right for
DyslipidemiasChildren, Only
Athens General Children's Hospital "Pan. & Aglaia Kyriakou" 90
Large-scale testing (Phase 3)Study completedNCT00694109
What this trial is testing

An Open-label Extension Study to Assess the Long-term Safety and Efficacy of ISIS 301012 (Mipomersen) in Patients With Familial Hypercholesterolemia or Severe-Hypercholesterolemia

Who this might be right for
Lipid Metabolism, Inborn ErrorsHypercholesterolemia, Autosomal DominantHyperlipidemias+11 more
Kastle Therapeutics, LLC 144
Large-scale testing (Phase 3)Study completedNCT02476006
What this trial is testing

Safety, Tolerability, and Effect of Alirocumab in High Cardiovascular Risk Patients With Severe Hypercholesterolemia Not Adequately Controlled With Conventional Lipid-modifying Therapies (ODYSSEY APPRISE)

Who this might be right for
Hypercholesterolemia
Sanofi 998
Large-scale testing (Phase 3)Study completedNCT02624869
What this trial is testing

Safety, Tolerability and Efficacy of Evolocumab (AMG 145) in Children With Inherited Elevated Low-density Lipoprotein Cholesterol (Familial Hypercholesterolemia)

Who this might be right for
Familial Hypercholesterolemia
Amgen 163
Post-approval studies (Phase 4)Study completedNCT02098460
What this trial is testing

To Compare the Effect of Concomitant Administration of Probucol and Cilostazol With Probucol Single Treatment on the Atherosclerosis Related Markers (Including the Thickness of the Achilles Tendon) and Evaluate Safety (Based on Atorvastatin Treatment) in Severe Hypercholesterolemia Subject

Who this might be right for
Severe Hypercholesterolemia
Otsuka Beijing Research Institute 300
Not applicableStudy completedNCT05974345
What this trial is testing

In Silico Study Assessing the Impact of Inclisiran on Major Adverse Cardiovascular Events in Patients With Established Cardiovascular Disease

Who this might be right for
Atherosclerotic Cardiovascular Disease
Novartis Pharmaceuticals 204,691
Large-scale testing (Phase 3)Study completedNCT01764633
What this trial is testing

Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk

Who this might be right for
Dyslipidemia
Amgen 27,564
Not applicableApproved For MarketingNCT06500598
What this trial is testing

Compassionate Use of Evinacumab

Who this might be right for
Pediatric Homozygous Familial Hypercholesterolemia (HoFH)Severe Hypertriglyceridemia (HTG)Dysbetalipoproteinemia (DBL)
Regeneron Pharmaceuticals
Not applicableStudy completedNCT03881657
What this trial is testing

Reverse Colocated Integrated Care Intervention Among Persons With Severe Persistent Mental Illness at US-Mexico Border

Who this might be right for
Mental Illness PersistentChronic DiseaseHypertension+4 more
Health Resources in Action, Inc. 416
Not applicableUnknownNCT04270344
What this trial is testing

The Occurrence of MACE in Patients With AMI Receiving Pitavastatin/Valsartan Treatment

Who this might be right for
Hypercholesterolemia
JW Pharmaceutical 905
Large-scale testing (Phase 3)Study completedNCT01624142
What this trial is testing

Trial Assessing Long Term USe of PCSK9 Inhibition in Subjects With Genetic LDL Disorders

Who this might be right for
Severe Familial Hypercholesterolemia
Amgen 300
Not applicableActive Not RecruitingNCT06832371
What this trial is testing

Evaluation of the Effect of Lomitapide Treatment on Major Adverse Cardiovascular Events (MACE) in Patients With Homozygous Familial Hypercholesterolemia

Who this might be right for
Homozygous Familial Hypercholesterolemia (HoFH)Major Adverse Cardiovascular Events (MACE)Dyslipidemia
Fondazione SISA (Societa Italiana per lo Studio della Arteriosclerosi) 73
Not applicableUnknownNCT04087915
What this trial is testing

Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With High Risk Coronary Artery Disease (FORWARD)

Who this might be right for
DyslipidemiaHigh Risk Coronary Artery Disease
Beijing Anzhen Hospital 1,000
Early research (Phase 1)Looking for participantsNCT07491172
What this trial is testing

A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory Dyslipidemias

Who this might be right for
CardiovascularMetabolic DiseaseDyslipidemias+7 more
CRISPR Therapeutics AG 90
Large-scale testing (Phase 3)Active Not RecruitingNCT05739383
What this trial is testing

Inclisiran to Prevent Cardiovascular Events in High-risk Primary Prevention Patients.

Who this might be right for
Primary Prevention of Atherosclerotic Cardiovascular Disease
Novartis Pharmaceuticals 14,012
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