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Results for “Severe Hypercholesterolemia”

32 trials

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Showing 20 of 32 results

Post-approval studies (Phase 4)Study completedNCT00405171
What this trial is testing

Efavirenz to Nevirapine Switch and Low-Density Lipoprotein (LDL)-Dyslipidemia

Who this might be right for
HIV InfectionsHypercholesterolemiaAntiretroviral Therapy
University Hospital, Caen 40
Not applicableEnded earlyNCT01173939
What this trial is testing

Primary Prevention of Major Adverse Cardiac Events (MACE) With Standard and Intensive Statin Treatment in Patients With Diabetes: Survival and Cardiovascular Event Assessments

Who this might be right for
HypercholesterolemiaType 2 DiabetesHypertension
Positive Trial Group 10,000
Large-scale testing (Phase 3)Study completedNCT01764633
What this trial is testing

Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk

Who this might be right for
Dyslipidemia
Amgen 27,564
Not applicableApproved For MarketingNCT06500598
What this trial is testing

Compassionate Use of Evinacumab

Who this might be right for
Pediatric Homozygous Familial Hypercholesterolemia (HoFH)Severe Hypertriglyceridemia (HTG)Dysbetalipoproteinemia (DBL)
Regeneron Pharmaceuticals
Large-scale testing (Phase 3)Study completedNCT02476006
What this trial is testing

Safety, Tolerability, and Effect of Alirocumab in High Cardiovascular Risk Patients With Severe Hypercholesterolemia Not Adequately Controlled With Conventional Lipid-modifying Therapies (ODYSSEY APPRISE)

Who this might be right for
Hypercholesterolemia
Sanofi 998
Not applicableUnknownNCT04270344
What this trial is testing

The Occurrence of MACE in Patients With AMI Receiving Pitavastatin/Valsartan Treatment

Who this might be right for
Hypercholesterolemia
JW Pharmaceutical 905
Not applicableStudy completedNCT03795038
What this trial is testing

Comparison of the Plasma Lipoprotein Apheresis Systems DIAMED and MONET vs. the Whole Blood Apheresis System DALI

Who this might be right for
Hypercholesterolemia, FamilialDyslipidemiasCardiovascular Diseases
Fresenius Medical Care Deutschland GmbH 20
Large-scale testing (Phase 3)Study completedNCT00694109
What this trial is testing

An Open-label Extension Study to Assess the Long-term Safety and Efficacy of ISIS 301012 (Mipomersen) in Patients With Familial Hypercholesterolemia or Severe-Hypercholesterolemia

Who this might be right for
Lipid Metabolism, Inborn ErrorsHypercholesterolemia, Autosomal DominantHyperlipidemias+11 more
Kastle Therapeutics, LLC 144
Not applicableTemporarily pausedNCT04031469
What this trial is testing

A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease

Who this might be right for
Gut MicrobiomeGastrointestinal MicrobiomeAutism+77 more
ProgenaBiome 1,000
Not applicableStudy completedNCT03881657
What this trial is testing

Reverse Colocated Integrated Care Intervention Among Persons With Severe Persistent Mental Illness at US-Mexico Border

Who this might be right for
Mental Illness PersistentChronic DiseaseHypertension+4 more
Health Resources in Action, Inc. 416
Large-scale testing (Phase 3)Study completedNCT02585895
What this trial is testing

Evolocumab Compared to LDL-C Apheresis in Patients Receiving LDL-C Apheresis Prior to Study Enrollment

Who this might be right for
Hypercholesterolemia
Amgen 39
Early research (Phase 1)Looking for participantsNCT07491172
What this trial is testing

A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory Dyslipidemias

Who this might be right for
CardiovascularMetabolic DiseaseDyslipidemias+7 more
CRISPR Therapeutics AG 90
Large-scale testing (Phase 3)Ended earlyNCT00766688
What this trial is testing

Evaluation of Safety and Efficacy of AVE5530 as add-on to Ongoing High Doses of Statins in Patients With Primary Severe Hypercholesterolemia

Who this might be right for
Hypercholesterolemia
Sanofi 643
Not applicableTemporarily pausedNCT05218304
What this trial is testing

Baromètre Santé Adulte 2021-2022

Who this might be right for
DiabetesHypercholesterolemiaRenal Failure+7 more
Agence Sanitaire et Sociale de Nouvelle Calédonie 5,471
Not applicableStudy completedNCT04481737
What this trial is testing

Peer-delivered and Technology-Assisted Integrated Illness Management and Recovery

Who this might be right for
SchizophreniaBipolar DisorderMajor Depressive Disorder, Recurrent+6 more
Dartmouth-Hitchcock Medical Center 40
Large-scale testing (Phase 3)Study completedNCT01598948
What this trial is testing

Effect of Mipomersen on LDL-Cholesterol Levels in Patients Treated by Regular Apheresis

Who this might be right for
AtherosclerosisLDL-hypercholesterolemia
Ludwig-Maximilians - University of Munich 17
Large-scale testing (Phase 3)Active Not RecruitingNCT05739383
What this trial is testing

Inclisiran to Prevent Cardiovascular Events in High-risk Primary Prevention Patients.

Who this might be right for
Primary Prevention of Atherosclerotic Cardiovascular Disease
Novartis Pharmaceuticals 14,012
Large-scale testing (Phase 3)Study completedNCT01624142
What this trial is testing

Trial Assessing Long Term USe of PCSK9 Inhibition in Subjects With Genetic LDL Disorders

Who this might be right for
Severe Familial Hypercholesterolemia
Amgen 300
Large-scale testing (Phase 3)Study completedNCT00794664
What this trial is testing

Safety and Efficacy of Mipomersen in Patients With Severe Hypercholesterolemia on a Maximally Tolerated Lipid-Lowering Regimen and Who Are Not on Apheresis

Who this might be right for
HypercholesterolemiaCoronary Heart Disease
Kastle Therapeutics, LLC 58
Large-scale testing (Phase 3)Study completedNCT02624869
What this trial is testing

Safety, Tolerability and Efficacy of Evolocumab (AMG 145) in Children With Inherited Elevated Low-density Lipoprotein Cholesterol (Familial Hypercholesterolemia)

Who this might be right for
Familial Hypercholesterolemia
Amgen 163
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