Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Severe Sickle Cell Disease”

109 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 109 results

Testing effectiveness (Phase 2)Looking for participantsNCT02447874
What this trial is testing

Arginine Therapy for the Treatment of Pain in Children With Sickle Cell Disease

Who this might be right for
Sickle Cell Disease
Emory University 21
Not applicableUnknownNCT04090268
What this trial is testing

Precision Exercise in Children With Malignant Hemopathies

Who this might be right for
Leukemia, Myeloid, AcuteLeukemia, B-cellLeukemia, T Cell+5 more
University of Milano Bicocca 380
Testing effectiveness (Phase 2)Study completedNCT00236041
What this trial is testing

Efficacy/Safety Study of ACTIQ® for Opioid-Tolerant Children and Adolescents With Breakthrough Pain (BTP)

Who this might be right for
CancerBreakthrough Pain
Cephalon 38
Testing effectiveness (Phase 2)Ended earlyNCT00041574
What this trial is testing

Hospital-Based Program for Treatment of Severe Cardiopulmonary Disease With Inhaled Nitric Oxide

Who this might be right for
Pulmonary HypertensionLung DiseaseSickle Cell Disease+2 more
Mallinckrodt 7
Not applicableLooking for participantsNCT07145411
What this trial is testing

HPC Offered for PRESERVE Expansion

Who this might be right for
Bone Marrow Transplant (BMT)
Ossium Health, Inc. 10
Not applicableNot Yet RecruitingNCT06698120
What this trial is testing

Awake Prone Positioning for Severe Acute Chest Syndrome

Who this might be right for
Acute Chest SyndromeSickle Cell Anemia
Assistance Publique - Hôpitaux de Paris 15
Not applicableStudy completedNCT01369160
What this trial is testing

Curative Versus Disease-Modifying Therapies in Children With Severe Sickle Cell Disease

Who this might be right for
Sickle Cell Disease
Emory University 33
Testing effectiveness (Phase 2)Study completedNCT00745420
What this trial is testing

Evaluating the Safety and Effectiveness of Bone Marrow Transplants in Children With Sickle Cell Disease (BMT CTN 0601)

Who this might be right for
Sickle Cell Disease
Medical College of Wisconsin 30
Testing effectiveness (Phase 2)Study completedNCT02435901
What this trial is testing

HSCT For Patients With High Risk Hemoglobinopathies Using Reduced Intensity

Who this might be right for
Sickle Cell DiseaseBeta Thalassemia-Major
Northwell Health 29
Not applicableUnknownNCT01105923
What this trial is testing

Study of an Intervention to Improve Problem List Accuracy and Use

Who this might be right for
Attention Deficit Disorder With HyperactivityAsthmaCOPD+16 more
Brigham and Women's Hospital 140
Early research (Phase 1)Ended earlyNCT04091737
What this trial is testing

CSL200 Gene Therapy in Adults With Severe Sickle Cell Disease

Who this might be right for
Anemia, Sickle Cell
CSL Behring 1
Very early researchLooking for participantsNCT06565026
What this trial is testing

CS-206 in Patients With Sickle Cell Disease

Who this might be right for
Sickle Cell Disease
CorrectSequence Therapeutics Co., Ltd 5
Large-scale testing (Phase 3)Looking for participantsNCT05477563
What this trial is testing

Evaluation of Efficacy and Safety of a Single Dose of CTX001 in Participants With Transfusion-Dependent β-Thalassemia and Severe Sickle Cell Disease

Who this might be right for
Beta-ThalassemiaThalassemiaHematologic Diseases+4 more
Vertex Pharmaceuticals Incorporated 26
Testing effectiveness (Phase 2)Looking for participantsNCT03214354
What this trial is testing

Nonmyeloablative Stem Cell Transplant in Children With Sickle Cell Disease and a Major ABO-Incompatible Matched Sibling Donor

Who this might be right for
Sickle Cell DiseaseStem Cell Transplant ComplicationsRed Blood Cell Disorder+1 more
University of Calgary 12
Testing effectiveness (Phase 2)Study completedNCT00004143
What this trial is testing

Allogeneic Mixed Chimerism Stem Cell Transplant Using Campath for Hemoglobinopathies & Bone Marrow Failure Syndromes

Who this might be right for
Sickle Cell AnemiaSevere Aplastic AnemiaParoxysmal Nocturnal Hemoglobinuria (PNH)+1 more
David Rizzieri, MD 2
Large-scale testing (Phase 3)Active Not RecruitingNCT05329649
What this trial is testing

Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With Severe Sickle Cell Disease (SCD)

Who this might be right for
Sickle Cell DiseaseHydroxyurea FailureHydroxyurea Intolerance+2 more
Vertex Pharmaceuticals Incorporated 13
Not applicableLooking for participantsNCT07000747
What this trial is testing

Molecular and Cellular Basis of Severe Forms of Dengue in Sickle Cell Patients

Who this might be right for
Dengue (Virus); Fever, SandflySickle Cell Disease
Centre Hospitalier Universitaire de la Guadeloupe 130
Testing effectiveness (Phase 2)Study completedNCT00236093
What this trial is testing

Extension Study of ACTIQ Treatment for Children and Adolescents With Breakthrough Pain

Who this might be right for
PainCancerSickle Cell Anemia+1 more
Cephalon
Testing effectiveness (Phase 2)Ended earlyNCT01279616
What this trial is testing

A Reduced Toxicity Allogeneic Unrelated Donor Stem Cell Transplantation (SCT) for Severe Sickle Cell Disease

Who this might be right for
Sickle Cell Disease
Nationwide Children's Hospital 8
Testing effectiveness (Phase 2)Ended earlyNCT03333486
What this trial is testing

Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood Cancer

Who this might be right for
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 PositiveAcute Leukemia in RemissionAcute Lymphoblastic Leukemia+34 more
Roswell Park Cancer Institute 31
Next Page