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Results for “Sickle B+ Thalassemia”

82 trials

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Showing 20 of 82 results

Testing effectiveness (Phase 2)Study completedNCT03763656
What this trial is testing

Pharmacokinetics of Oral Hydroxyurea Solution

Who this might be right for
Sickle Cell DiseaseSickle-Cell; Hemoglobin Disease, ThalassemiaSickle Cell-beta-thalassemia+1 more
Nova Laboratories Limited 33
Early research (Phase 1)Active Not RecruitingNCT03282656
What this trial is testing

Gene Transfer for Sickle Cell Disease

Who this might be right for
Sickle Cell Disease
David Williams 10
Testing effectiveness (Phase 2)Study completedNCT04987489
What this trial is testing

Etavopivat in Patients With Thalassemia or Sickle Cell Disease

Who this might be right for
Sickle Cell DiseaseThalassemia
Forma Therapeutics, Inc. 53
Testing effectiveness (Phase 2)Looking for participantsNCT05736419
What this trial is testing

Immune Suppression Treatment for People With Sickle Cell Disease or β-Thalassemia Who Are Going to Receive an Allogeneic Hematopoietic Cell Transplantation (HCT)

Who this might be right for
Sickle Cell DiseaseThalassemia, BetaThalassemia
Memorial Sloan Kettering Cancer Center 24
Early research (Phase 1)Study completedNCT01039636
What this trial is testing

Safety and Pharmacokinetic Study of Escalating Multiple Doses of an Iron Chelator in Patients With Iron Overload

Who this might be right for
Transfusional Iron OverloadBeta-thalassemia
FerroKin BioSciences, Inc. 20
Testing effectiveness (Phase 2)Looking for participantsNCT04008368
What this trial is testing

Repeat Peripheral Blood Stem Cell Transplantation for Patients With Sickle Cell Disease and Falling Donor Myeloid Chimerism Levels

Who this might be right for
Myeloid Chimerism
National Heart, Lung, and Blood Institute (NHLBI) 32
Testing effectiveness (Phase 2)Active Not RecruitingNCT00061568
What this trial is testing

Improving the Results of Bone Marrow Transplantation for Patients With Severe Congenital Anemias

Who this might be right for
Congenital Hemolytic AnemiaSickle Cell Disease
National Heart, Lung, and Blood Institute (NHLBI) 130
Not applicableEnrolling By InvitationNCT06363760
What this trial is testing

A Long-Term Follow-Up Study of Participants With Sickle Cell Disease or Transfusion Dependent β-Thalassemia Who Received EDIT-301

Who this might be right for
Sickle Cell DiseaseTransfusion-dependent Beta-ThalassemiaHemoglobinopathies
Editas Medicine, Inc. 54
Not applicableLooking for participantsNCT01758042
What this trial is testing

Bone Marrow and Kidney Transplant for Patients With Chronic Kidney Disease and Blood Disorders

Who this might be right for
Chronic Kidney DiseaseAcute Myeloid Leukemia (AML)Acute Lymphoblastic Leukemia (ALL)+14 more
Massachusetts General Hospital 10
Testing effectiveness (Phase 2)Ended earlyNCT01000155
What this trial is testing

Efficacy of Vorinostat to Induce Fetal Hemoglobin in Sickle Cell Disease

Who this might be right for
Sickle Cell DiseaseSickle Cell Anemia
Dana-Farber Cancer Institute 5
Not applicableActive Not RecruitingNCT04523376
What this trial is testing

Pilot Study PBSCT with TCRab Depletion for Hemoglobinopathies

Who this might be right for
Sickle Cell DiseaseThalassemia Major
Timothy Olson 9
Not applicableEnrolling By InvitationNCT06664541
What this trial is testing

Decision-Making and Quality of Life Surrounding Hematologic Disease and Gene Therapy

Who this might be right for
Transfusion Dependent Beta ThalassemiaSickle Cell Disease
Georgetown University 100
Testing effectiveness (Phase 2)Active Not RecruitingNCT02105766
What this trial is testing

Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People With Higher Risk of Transplant Failure

Who this might be right for
Sickle Cell DiseaseThalassemiaStem Cell Transplantation+1 more
National Heart, Lung, and Blood Institute (NHLBI) 56
Large-scale testing (Phase 3)Looking for participantsNCT05477563
What this trial is testing

Evaluation of Efficacy and Safety of a Single Dose of CTX001 in Participants With Transfusion-Dependent β-Thalassemia and Severe Sickle Cell Disease

Who this might be right for
Beta-ThalassemiaThalassemiaHematologic Diseases+4 more
Vertex Pharmaceuticals Incorporated 26
Testing effectiveness (Phase 2)Active Not RecruitingNCT02061800
What this trial is testing

CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell Transplant

Who this might be right for
Chronic Myeloid Leukemia (CML)Acute Myelogenous Leukemia (AML)Myelodysplastic Syndrome (MDS)+3 more
Diane George 14
Not applicableLooking for participantsNCT04528355
What this trial is testing

Data Collection Study of Patients With Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT With RIC

Who this might be right for
Primary Immunodeficiency (PID)Congenital Bone Marrow Failure SyndromesInherited Metabolic Disorders (IMD)+2 more
Paul Szabolcs 50
Not applicableLooking for participantsNCT03937817
What this trial is testing

Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants

Who this might be right for
Alpha and Beta ThalassemiaSickle Cell DiseaseMalaria+1 more
National Institute of Allergy and Infectious Diseases (NIAID) 300
Early research (Phase 1)Study completedNCT02712346
What this trial is testing

The Role of Endothelin-1 in Sickle Cell Disease

Who this might be right for
Sickle Cell Anemia
Augusta University 26
Not applicableLooking for participantsNCT05799118
What this trial is testing

Study of the Role of Genetic Modifiers in Hemoglobinopathies

Who this might be right for
Sickle Cell DiseaseThalassemia, BetaThalassemia Alpha+1 more
Cyprus Institute of Neurology and Genetics 30,000
Not applicableStudy completedNCT04675645
What this trial is testing

Adherence to HU and HRQOL in Patients With Sickle Cell Disease: An Intervention Study Using HU-Go App

Who this might be right for
Sickle Cell DiseaseSickle B+ ThalassemiaSickle Beta Zero Thalassemia+1 more
Ann & Robert H Lurie Children's Hospital of Chicago 33
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