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Results for “Sickle Cell Anemia (HbSS)”

15 trials

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Showing 15 of 15 results

Testing effectiveness (Phase 2)Study completedNCT03401112
What this trial is testing

IMR-687 in Adult Participants With Sickle Cell Anemia (Homozygous HbSS or Sickle-β0 Thalassemia)

Who this might be right for
Sickle Cell Disease
Cardurion Pharmaceuticals, Inc. 100
Not applicableNot Yet RecruitingNCT06743113
What this trial is testing

Hypoxic Red Blood Cells in Sickle Cell Anemia

Who this might be right for
Sickle Cell AnaemiaSickle Cell Anemia CrisisSickle Cell Anemia in Children+1 more
Hemanext 48
Testing effectiveness (Phase 2)Active Not RecruitingNCT04053803
What this trial is testing

An Extension Study of IMR-687 in Adult Patients With Sickle Cell Anemia

Who this might be right for
Sickle Cell Disease
Imara, Inc. 30
Testing effectiveness (Phase 2)Study completedNCT01960413
What this trial is testing

Phase 2 Study of Montelukast for the Treatment of Sickle Cell Anemia

Who this might be right for
Sickle Cell Anemia (HbSS, or HbSβ-thalassemia0)
Vanderbilt University Medical Center 46
Early research (Phase 1)Not Yet RecruitingNCT07799571
What this trial is testing

Buprenorphine for the Management of Pain in Children With Sickle Cell Disease

Who this might be right for
Sickle Cell Disease (SCD)Sickle Cell Disease Vaso-occlusive CrisisSickle Cell Anemia Crisis+4 more
Natasha Archer 25
Not applicableUnknownNCT01242878
What this trial is testing

MACS Study - Microparticles and Coagulation in Sickle Cell Disease

Who this might be right for
Sickle Cell Disease
University College, London 360
Not applicableNot Yet RecruitingNCT07540767
What this trial is testing

Development of a Provider-Focused Intervention to Improve Health Outcomes in Pediatric Sickle Cell Disease

Who this might be right for
Sickle Cell DiseaseSickle Cell Anemia in ChildrenSickle Cell Disease (SCD)+2 more
Connecticut Children's Medical Center 30
Testing effectiveness (Phase 2)Looking for participantsNCT07175051
What this trial is testing

Targeting the Pathophysiology of Sickle Cell-Related Kidney Disease Using the SGLT2 Inhibitors, Empagliflozin

Who this might be right for
Sickle Cell Anemia (HbSS, or HbSβ-thalassemia0)Albuminuria
University of Illinois at Chicago 20
Not applicableStudy completedNCT02242058
What this trial is testing

QST-Pupillometry in Sickle Cell Disease Patients

Who this might be right for
SCD With Severe Phenotype (HbSS, HbSβ0 Thalassemia, HbSOARab)
Julia Finkel 96
Testing effectiveness (Phase 2)Study completedNCT02844673
What this trial is testing

Mobile-Directly Observed Therapy on Adherence to Hydroxyurea

Who this might be right for
Sickle Cell Anaemia
Muhimbili University of Health and Allied Sciences 98
Early research (Phase 1)Not Yet RecruitingNCT07708350
What this trial is testing

Hematopoietic Stem Cell BCL11A Enhancer Gene Editing for Sickle Cell Disease

Who this might be right for
Sickle Cell DiseaseSickle Cell Anemia (HbSS, or HbSβ-thalassemia0)
Daniel Bauer 5
Not applicableActive Not RecruitingNCT05675436
What this trial is testing

Investigating the Mechanistic Effects of Mitapivat in Subjects With Sickle Cell Disease

Who this might be right for
Sickle Cell AnemiaSickle Cell ThalassemiaSickle Cell Pain+5 more
National Heart, Lung, and Blood Institute (NHLBI) 6
Large-scale testing (Phase 3)Study completedNCT03789591
What this trial is testing

Hydroxyurea Optimization Through Precision Study

Who this might be right for
Sickle Cell DiseaseSickle Cell Anemia
Lifespan 104
Early research (Phase 1)Looking for participantsNCT06647979
What this trial is testing

Hematopoietic Stem Cell BCL11A Enhancer Gene Editing for Severe β-Hemoglobinopathies

Who this might be right for
Sickle Cell DiseaseSickle Cell Anemia (HbSS, or HbSβ-thalassemia0)Beta-Thalassemia+1 more
Daniel Bauer 10
Post-approval studies (Phase 4)Looking for participantsNCT07177300
What this trial is testing

Effectiveness of Nontraditional Hydroxyurea Algorithms: Novel and Clinical Evaluations (ENHANCE)

Who this might be right for
Sickle Cell Anemia (HbSS)Sickle-β0-thalassemia (HbSβ0)
Children's Hospital Medical Center, Cincinnati 50