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Results for “Single-gene Disorders”

400 trials

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Showing 20 of 400 results

Very early researchUnknownNCT03728322
What this trial is testing

IHSCs With the Gene Correction of HBB Intervent Subjests With β-thalassemia Mutations

Who this might be right for
Thalassemia
Allife Medical Science and Technology Co., Ltd. 12
Not applicableStudy completedNCT04707612
What this trial is testing

VDR SNPs & 25OHD Correlated With Dyslipidemia

Who this might be right for
DyslipidemiasSingle Nucleotide Polymorphism
Shenzhen Center for Chronic Disease Control 1,987
Not applicableLooking for participantsNCT06147414
What this trial is testing

Development of Non-Invasive Prenatal Diagnosis for Single Gene Disorders

Who this might be right for
Invasive PreNatal Diagnosis in a Context of Family History of Single-gene Disorders, IncludingSickle Cell DiseaseCystic Fibrosis+12 more
Assistance Publique - Hôpitaux de Paris 550
Not applicableNot Yet RecruitingNCT07014904
What this trial is testing

"Cytotoxic T Lymphocyte-Associated Antigen-4 (CTLA-4) Gene Single-nucleotide Polymorphism in Primary Immune Thrombocytopenic Purpura in Children"

Who this might be right for
ITP - Immune Thrombocytopenia
Sohag University 80
Not applicableUnknownNCT00665171
What this trial is testing

Whole Genome Analysis for the Detection of Key Genes in the Polycystic Ovary Syndrome

Who this might be right for
AnovulationHyperandrogenismPolycystic Ovary Syndrome+1 more
Maaynei Hayesha Medical Center 1,500
Very early researchNot Yet RecruitingNCT06178432
What this trial is testing

Evaluation of the Safety, Tolerability and Efficacy of Gene Therapy Drug for Late Onset Pompe Disease (LOPD)

Who this might be right for
Pompe Disease (Late-onset)
Huashan Hospital 6
Very early researchNot Yet RecruitingNCT06963008
What this trial is testing

A Prospective, Single-center, Open-label Clinical Study to Evaluate the Safety and Efficacy of Inhaled BMD003(CFTR mRNA) in Chinese Adult Patients With Cystic Fibrosis

Who this might be right for
Cystic Fibrosis (CF)Gene Therapy
Peking Union Medical College Hospital 12
Very early researchLooking for participantsNCT06860672
What this trial is testing

Clinical Trial of the Dual Vector Base Editor for the Treatment of the CHD3-R1025W Mutation

Who this might be right for
Developmental Delay DisorderIntellectual DisabilityRare Diseases
Yongguo Yu 1
Not applicableUnknownNCT01780415
What this trial is testing

Genomic DNA in Human Blastocoele Fluid

Who this might be right for
Chromosomal AneuploidiesSingle Gene Desease
Cervesi Hospital, Cattolica, Italy 35
Large-scale testing (Phase 3)Study completedNCT02282020
What this trial is testing

Olaparib Treatment in Relapsed Germline Breast Cancer Susceptibility Gene (BRCA) Mutated Ovarian Cancer Patients Who Have Progressed at Least 6 Months After Last Platinum Treatment and Have Received at Least 2 Prior Platinum Treatments

Who this might be right for
Relapsed Ovarian Cancer, BRCA Mutation, Platinum Sensitivity
AstraZeneca 266
Not applicableStudy completedNCT00992420
What this trial is testing

Genotype Information and Functional Testing Study

Who this might be right for
Coronary Artery Disease
Scripps Health 2,000
Large-scale testing (Phase 3)Study completedNCT03370913
What this trial is testing

Single-Arm Study To Evaluate The Efficacy and Safety of Valoctocogene Roxaparvovec in Hemophilia A Patients (BMN 270-301)

Who this might be right for
Hemophilia A
BioMarin Pharmaceutical 144
Not applicableStudy completedNCT04544033
What this trial is testing

IL- 6 Gene (174G/C) Single Nucleotide Polymorphism as an Indicator of COVID-19 Severity in Egyptian Patients

Who this might be right for
Covid19
Tanta University 120
Not applicableUnknownNCT02502214
What this trial is testing

Feasibility Study of Preimplantation Genetic Diagnosis for Single-gene Disorders

Who this might be right for
Preimplantation Diagnosis
University Hospital, Strasbourg, France 30
Testing effectiveness (Phase 2)Study completedNCT01867333
What this trial is testing

Enzalutamide With or Without Vaccine Therapy for Advanced Prostate Cancer

Who this might be right for
Prostate Cancer
National Cancer Institute (NCI) 57
Large-scale testing (Phase 3)Study completedNCT03306277
What this trial is testing

Gene Replacement Therapy Clinical Trial for Participants With Spinal Muscular Atrophy Type 1

Who this might be right for
SMA - Spinal Muscular AtrophyGene Therapy
Novartis Gene Therapies 22
Not applicableStudy completedNCT00340119
What this trial is testing

Genetic Susceptibility to Cardiovascular Disease in Patients on Kidney Dialysis

Who this might be right for
End Stage Renal DiseaseESRD
National Cancer Institute (NCI) 871
Testing effectiveness (Phase 2)Active Not RecruitingNCT03087071
What this trial is testing

Panitumumab With or Without Trametinib in Treating Patients With Stage IV Colorectal Cancer

Who this might be right for
EGFR NP_005219.2:p.S492RKRAS Gene MutationMAP2K1 Gene Mutation+5 more
M.D. Anderson Cancer Center 59
Testing effectiveness (Phase 2)Looking for participantsNCT07002398
What this trial is testing

Safety and Preliminary Efficacy of VG801 in Patients With ABCA4 Mutation-associated Retinal Dystrophy (Stargardt Disease)

Who this might be right for
Retinal Dystrophy Due to Biallelic ABCA4 MutationsStargardt Disease 1
VeonGen Therapeutics GmbH 15
Testing effectiveness (Phase 2)Looking for participantsNCT06300424
What this trial is testing

Neoadjuvant Almonertinib Followed by Chemo-immunotherapy in II-IIIB EGFR-mutant NSCLC

Who this might be right for
Non Small Cell Lung CancerEGFR Gene Mutation
Guangdong Provincial People's Hospital 32
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