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Results for “Somatic Mutation”

84 trials

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Showing 20 of 84 results

Not applicableLooking for participantsNCT06357845
What this trial is testing

Linking Somatic Mutation Rate With Baseline Exposure in East Palestine

Who this might be right for
Somatic Mutation
Case Comprehensive Cancer Center 500
Large-scale testing (Phase 3)Active Not RecruitingNCT04497844
What this trial is testing

Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-MutatedProstatic Neoplasms (mCSPC)

Who this might be right for
Prostatic Neoplasms
Janssen Research & Development, LLC 696
Testing effectiveness (Phase 2)UnknownNCT04486937
What this trial is testing

SC10914 Monotherapy for the mCRPC With g/s BRCA Mutation

Who this might be right for
Metastatic Castration Resistant Prostate Cancer
Jiangxi Qingfeng Pharmaceutical Co. Ltd. 90
Large-scale testing (Phase 3)Not Yet RecruitingNCT07569081
What this trial is testing

A Study Evaluating the Efficacy and Safety of Momelotinib in Participants With Vacuoles, E1-enzyme, X-linked, Autoinflammatory, Somatic (VEXAS) Syndrome

Who this might be right for
VEXAS Syndrome
GlaxoSmithKline 136
Not applicableStudy completedNCT02761473
What this trial is testing

Cutaneous Mastocytosis in Children: Analysis of Somatic and Germline Mutations

Who this might be right for
Urticaria PigmentosaCutaneous Mastocytosis
University of Minnesota 50
Not applicableUnknownNCT04280666
What this trial is testing

Next-generation Sequencing of Colorectal Cancer Somatic Cells to Guide Genetic Susceptibility Gene Mutations Screening.

Who this might be right for
Hereditary Colorectal Cancer
Fudan University 100
Testing effectiveness (Phase 2)Study completedNCT01482715
What this trial is testing

Oral Rucaparib in Patients With a Solid Tumor (Phase I) or With gBRCA Mutation Ovarian Cancer (Phase II)

Who this might be right for
Ovarian CancerFallopian Tube CancerPeritoneal Cancer+1 more
pharmaand GmbH 136
Testing effectiveness (Phase 2)Ended earlyNCT01953926
What this trial is testing

Basket Study of Neratinib in Participants With Solid Tumors Harboring Somatic HER2 or EGFR Exon 18 Mutations

Who this might be right for
Solid Tumors Harboring Somatic HER2 or EGFR Exon 18 Mutations
Puma Biotechnology, Inc. 582
Not applicableEnrolling By InvitationNCT06851052
What this trial is testing

SMS - Study of Somatic Mutations Using Genome Sequencing

Who this might be right for
Somatic Mutation
The Wellcome Sanger Institute 600
Not applicableLooking for participantsNCT01994057
What this trial is testing

A Retrospective Study of EGFR-TKIs,Gefitinib, Erlotinib and Osimertinib in NSCLC Patients Treatment

Who this might be right for
Non-small Cell Lung Cancer (NSCLC)EGFR-TKI Resistant MutationEGFR-TKI Sensitizing Mutation+2 more
Sun Yat-sen University 1,000
Testing effectiveness (Phase 2)UnknownNCT03553004
What this trial is testing

Niraparib in Metastatic Pancreatic Cancer After Previous Chemotherapy (NIRA-PANC): a Phase 2 Trial

Who this might be right for
Pancreatic Cancer
University of Kansas Medical Center 18
Testing effectiveness (Phase 2)Looking for participantsNCT06741085
What this trial is testing

Stereotactic Radiosurgery (SRS) and Standard Treatment in People With Lung Cancer That Has Spread to the Brain

Who this might be right for
Non Small Cell Lung Cancer Metastatic
Memorial Sloan Kettering Cancer Center 56
Not applicableEnrolling By InvitationNCT03901521
What this trial is testing

Autosomal Dominant Polycystic Kidney Disease Somatic Mutation Biorepository

Who this might be right for
Autosomal Dominant Polycystic Kidney Disease
Weill Medical College of Cornell University 100
Testing effectiveness (Phase 2)WithdrawnNCT05512182
What this trial is testing

Efficacy of Triplet Combination With Pembrolizumab, Neratinib, and Paclitaxel as a Second Line Treatment in Recurrent/Advanced Gastric Cancer Having Somatic Human Epidermal Growth Factor Receptor Family (EGFR, HER2, HER3, HER4) Mutations or HER2 Amplification/Overexpression

Who this might be right for
Recurrent/Advanced Gastric Cancer
Yonsei University
Testing effectiveness (Phase 2)Ended earlyNCT04390243
What this trial is testing

Binimetinib and Encorafenib for the Treatment of Pancreatic Cancer in Patients With a Somatic BRAF V600E Mutation

Who this might be right for
Locally Advanced Pancreatic CarcinomaMetastatic Pancreatic CarcinomaRecurrent Pancreatic Carcinoma+2 more
Academic and Community Cancer Research United 6
Not applicableLooking for participantsNCT02288676
What this trial is testing

DOvEEgene/WISE Genomics: Diagnosing Ovarian and Endometrial Cancer Early Using Genomics

Who this might be right for
Ovarian NeoplasmsEndometrial NeoplasmsEndometrial Cancer+6 more
McGill University 1,200
Not applicableStudy completedNCT02883517
What this trial is testing

Cell-free Circulating DNA in Primary Cutaneous Lymphomas

Who this might be right for
Mycosis FungoidesLymphoma, Large B-cell, Diffuse
University Hospital, Bordeaux 35
Not applicableUnknownNCT03301961
What this trial is testing

Multiplex Analysis of Circulating Tumor DNA

Who this might be right for
CarcinomaNon-small-cell Lung CancerLung Neoplasm
Peking University People's Hospital 400
Not applicableUnknownNCT01927809
What this trial is testing

Genetic Mosaicism in Hirschsprung's Disease

Who this might be right for
Hirschsprung Disease
Erasmus Medical Center 90
Testing effectiveness (Phase 2)Looking for participantsNCT05735717
What this trial is testing

MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies

Who this might be right for
Hematologic MalignancyAcute LeukemiaRemission+21 more
Masonic Cancer Center, University of Minnesota 70
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