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Results for “Somatic Mutation”

81 trials

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Showing 20 of 81 results

Testing effectiveness (Phase 2)Ended earlyNCT04390243
What this trial is testing

Binimetinib and Encorafenib for the Treatment of Pancreatic Cancer in Patients With a Somatic BRAF V600E Mutation

Who this might be right for
Locally Advanced Pancreatic CarcinomaMetastatic Pancreatic CarcinomaRecurrent Pancreatic Carcinoma+2 more
Academic and Community Cancer Research United 6
Not applicableLooking for participantsNCT04258449
What this trial is testing

DOvEEgene Fleur: New Uterine Sampling Tool

Who this might be right for
Women With Suspected or Confirmed Gynecological Disease
McGill University 40
Not applicableUnknownNCT02207686
What this trial is testing

Assessment of Residual VHL Function in Tumors - Can it Predict the Patients' Individual Course of Disease?

Who this might be right for
Von Hippel-Lindaus Disease
Marie Luise Bisgaard, MD 50
Not applicableUnknownNCT01927809
What this trial is testing

Genetic Mosaicism in Hirschsprung's Disease

Who this might be right for
Hirschsprung Disease
Erasmus Medical Center 90
Not applicableLooking for participantsNCT06425146
What this trial is testing

Tobacco, Alcohol and Cancerization of the Oral Mucosa (TACO)

Who this might be right for
Oral Squamous Cell Carcinomas
Centre Leon Berard 30
Testing effectiveness (Phase 2)Ended earlyNCT02595840
What this trial is testing

Biomarker Study Accompanying the AIO-TRK-0114 Study (MARBLE)

Who this might be right for
Non-small-cell Lung Cancer With Somatic EGFR Mutations
Universität Duisburg-Essen 4
Not applicableEnrolling By InvitationNCT03901521
What this trial is testing

Autosomal Dominant Polycystic Kidney Disease Somatic Mutation Biorepository

Who this might be right for
Autosomal Dominant Polycystic Kidney Disease
Weill Medical College of Cornell University 100
Testing effectiveness (Phase 2)Active Not RecruitingNCT03967938
What this trial is testing

Efficacy of Olaparib in Advanced Cancers Occurring in Patients With Germline Mutations or Somatic Tumor Mutations in Homologous Recombination Genes

Who this might be right for
Advanced Cancers Harbouring Mutations in HRG
AZ-VUB 540
Testing effectiveness (Phase 2)Looking for participantsNCT05735717
What this trial is testing

MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies

Who this might be right for
Hematologic MalignancyAcute LeukemiaRemission+19 more
Masonic Cancer Center, University of Minnesota 70
Testing effectiveness (Phase 2)Study completedNCT04089189
What this trial is testing

Study of IMP4297 in Patients With BRCA1/2 Mutation Ovarian Cancer

Who this might be right for
Ovarian Cancer
Impact Therapeutics, Inc. 93
Early research (Phase 1)Looking for participantsNCT04890613
What this trial is testing

Study of CX-5461 in Patients With Solid Tumours and BRCA1/2, PALB2 or Homologous Recombination Deficiency (HRD) Mutation

Who this might be right for
Advanced Solid Tumor
Senhwa Biosciences, Inc. 52
Not applicableUnknownNCT04174547
What this trial is testing

An European Platform for Translational Research in Myelodysplastic Syndromes

Who this might be right for
Myelodysplastic Syndromes
Istituto Clinico Humanitas 8,670
Not applicableLooking for participantsNCT03538665
What this trial is testing

The DETECT Study: Discovery and Evaluation of Testing for Endometrial and Ovarian Cancer in Tampons

Who this might be right for
Endometrial CancerEndometrial Cancer PrecursorsOvarian Cancer+1 more
University of Alabama at Birmingham 1,500
Not applicableStudy completedNCT04314245
What this trial is testing

Diagnostic Evaluation of Urine DNA Methylation/Somatic Mutation Profiling for the Detection of Urothelial Carcinoma

Who this might be right for
Urothelial CarcinomaBladder Cancer
AnchorDx Medical Co., Ltd. 1,170
Large-scale testing (Phase 3)WithdrawnNCT02392676
What this trial is testing

Olaparib Maintenance Treatment Versus Placebo in Patients With PSR Ovarian Cancer Who Are in CR or PR to Platinum-based Chemotherapy and Whose Tumours Carry sBRCAm or HRR-associated Genes Mutations

Who this might be right for
Platinum Sensitive Relapsed Ovarian Cancer
AstraZeneca
Not applicableStudy completedNCT01251159
What this trial is testing

Biomarkers in Bone Marrow Samples From Patients With Acute Myeloid Leukemia

Who this might be right for
Leukemia
ECOG-ACRIN Cancer Research Group 30
Not applicableUnknownNCT04280666
What this trial is testing

Next-generation Sequencing of Colorectal Cancer Somatic Cells to Guide Genetic Susceptibility Gene Mutations Screening.

Who this might be right for
Hereditary Colorectal Cancer
Fudan University 100
Testing effectiveness (Phase 2)Active Not RecruitingNCT04053322
What this trial is testing

Durvalumab, With Olaparib and Fulvestrant in Advanced ER+, HER2- Breast Cancer Patients.

Who this might be right for
ER-positive and HER2-negative Metastatic or Locally Advanced Breast Cancera Germline or Somatic BRCA Mutation, or a Deleterious Alteration of Other Genes Involved in Homologous Recombination Repair (HRR) or in MSI Status
UNICANCER 172
Not applicableStudy completedNCT02761473
What this trial is testing

Cutaneous Mastocytosis in Children: Analysis of Somatic and Germline Mutations

Who this might be right for
Urticaria PigmentosaCutaneous Mastocytosis
University of Minnesota 50
Very early researchWithdrawnNCT04776980
What this trial is testing

Multimodality MRI and Liquid Biopsy in GBM

Who this might be right for
Glioblastoma MultiformeBrain Tumor, Adult: GlioblastomaBrain Tumor, Recurrent+1 more
Abramson Cancer Center at Penn Medicine
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