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Results for “Spastic Paraplegia, Hereditary”

50 trials

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Showing 20 of 50 results

Not applicableLooking for participantsNCT04875416
What this trial is testing

Phenotype, Genotype and Biomarkers 2

Who this might be right for
Amyotrophic Lateral SclerosisHereditary Spastic ParaplegiaPrimary Lateral Sclerosis+2 more
University of Miami 300
Not applicableLooking for participantsNCT06936163
What this trial is testing

A Prospective Cohort Study of Surgical Treatment for Foot Deformities in HSP

Who this might be right for
Hereditary Spastic Paraplegia
Shanghai 6th People's Hospital 100
Testing effectiveness (Phase 2)Study completedNCT04768166
What this trial is testing

Testing Miglustat Administration in Subjects With Spastic Paraplegia 11

Who this might be right for
Hereditary Spastic Paraparesis
IRCCS Fondazione Stella Maris 10
Not applicableEnded earlyNCT02859428
What this trial is testing

Disease Natural History and Biomarkers of SPG3A, SPG4A, and SPG31

Who this might be right for
Hereditary Spastic Paraplegia
National Institute of Neurological Disorders and Stroke (NINDS) 51
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06948019
What this trial is testing

Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47)

Who this might be right for
HSPHereditary Spastic ParaplegiaHereditary Spastic Paraparesis+10 more
BlackfinBio Ltd 5
Not applicableStudy completedNCT05174403
What this trial is testing

Imaging Biomarkers in Spastic Paraplegia Type 5

Who this might be right for
Spastic Paraplegia Type 5A, Recessive
Assistance Publique - Hôpitaux de Paris 10
Early research (Phase 1)Study completedNCT06117020
What this trial is testing

Single and Multiple Ascending Dose Study of MTR-601 in Healthy Individuals

Who this might be right for
Muscle SpasticityHypertonia, MuscleCerebral Palsy+5 more
Motric Bio 89
Not applicableLooking for participantsNCT06260982
What this trial is testing

Cognitive Disorders in Hereditary Spastic Paraplegia Type 4

Who this might be right for
Spastic Paraplegia
Central Hospital, Nancy, France 30
Not applicableStudy completedNCT06740006
What this trial is testing

Retrospective Study on the WalkOn AFO in Children or Teenagers With Neurological Pathologies

Who this might be right for
Cerebral Palsy (CP)Spastic ParaplegiaSpinal Cord Injuries (SCI)+2 more
Otto Bock France SNC 65
Large-scale testing (Phase 3)Looking for participantsNCT06692712
What this trial is testing

Phase 3 Efficacy Study With Concurrent Control of IT MELPIDA in SPG50.Concurrent Controls.

Who this might be right for
Hereditary Spastic Paraplegia Type 50
Elpida Therapeutics SPC 24
Not applicableStudy completedNCT05613114
What this trial is testing

Effect of Dalfampridine in Patients With Hereditary Spastic Paraplegia

Who this might be right for
Hereditary Spastic Paraplegia
European University of Lefke 8
Not applicableLooking for participantsNCT05848271
What this trial is testing

Natural History Study of Patients with HPDL Mutations

Who this might be right for
Mitochondrial EncephalomyopathiesHereditary Spastic ParaplegiaSpastic Paraplegia+4 more
University of California, San Diego 50
Not applicableLooking for participantsNCT06572046
What this trial is testing

STOP-HSP.Net: a Registry for Hereditary Spastic Paraplegia as an Integration Tool for Future Therapeutic Strategies

Who this might be right for
Hereditary Spastic Paraplegia
IRCCS Fondazione Stella Maris 500
Not applicableStudy completedNCT00677768
What this trial is testing

Validation of Biomarkers in Amyotrophic Lateral Sclerosis (ALS)

Who this might be right for
Amyotrophic Lateral SclerosisLou Gehrig's DiseasePrimary Lateral Sclerosis+2 more
Massachusetts General Hospital 475
Testing effectiveness (Phase 2)Study completedNCT02314208
What this trial is testing

Therapeutic Metabolic Intervention in Patients With Spastic Paraplegia SPG5

Who this might be right for
Spastic Paraplegia, Hereditary
Institut National de la Santé Et de la Recherche Médicale, France 12
Not applicableLooking for participantsNCT01568658
What this trial is testing

Genetic and Physical Study of Childhood Nerve and Muscle Disorders

Who this might be right for
Muscular DystrophiesMuscle MyopathiesHereditary Spastic Paraplegias+2 more
National Institute of Neurological Disorders and Stroke (NINDS) 9,300
Not applicableStudy completedNCT00136630
What this trial is testing

Natural History, Genetic Bases and Phenotype-genotype Correlations in Autosomal Dominant Spinocerebellar Degenerations

Who this might be right for
Spinocerebellar AtaxiasSpastic Paraplegias
Institut National de la Santé Et de la Recherche Médicale, France 175
Testing effectiveness (Phase 2)Ended earlyNCT05394064
What this trial is testing

Evaluate Administration of SBT101 Gene Therapy in Adult Patients With Adrenomyeloneuropathy (AMN)

Who this might be right for
AMNAMN Gene MutationX-ALD
SwanBio Therapeutics, Inc. 8
Not applicableLooking for participantsNCT06092346
What this trial is testing

A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders

Who this might be right for
AMPD3, OMIM*102772, AMP Deaminase DeficiencyAK1, OMIM *103000, Adenylate Kinase DeficiencyAMPD1, OMIM *102770, Myopathy Due to Myoadenylate Deaminase Deficiency+25 more
National Human Genome Research Institute (NHGRI)
Not applicableStudy completedNCT05767268
What this trial is testing

Assessment of the Psychophysical State During Rehabilitation Treatment With Lokomat

Who this might be right for
Cerebral PalsyAcquired Brain InjuryHereditary Spastic Paraplegia
IRCCS Eugenio Medea 48
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