Post-approval studies (Phase 4)UnknownNCT01128101What this trial is testingEffects of Spironolactone in DialysisWho this might be right forRenal Failure UPECLIN HC FM Botucatu Unesp 60
Testing effectiveness (Phase 2)Study completedNCT02235077What this trial is testingStudy of High-dose Spironolactone vs. Placebo Therapy in Acute Heart FailureWho this might be right forHeart Failure Duke University 360
Post-approval studies (Phase 4)Not Yet RecruitingNCT07523867What this trial is testingSpironolactone Alternate Dosing vs Finerenone in Elevated Potassium - K Safety StudyWho this might be right forHeart FailureDiabetic Kidney DiseaseHyperkalemia Hospital de Messejana Dr. Carlos Alberto Studart Gomes 60
Large-scale testing (Phase 3)Study completedNCT07043634What this trial is testingEvaluate the Effect of Food or no Food on the Bioavailability of an Extended Release (ER) Torsemide and Spironolactone Fixed Dose Combination (FDC) Tablet in Healthy Adult SubjectsWho this might be right forBioavailability Heathy Volunteers Sarfez Pharmaceuticals, Inc. 24
Post-approval studies (Phase 4)Study completedNCT02883400What this trial is testingSpironolactone After Liver TransplantWho this might be right forTransplant, Liver Wake Forest University Health Sciences 30
Testing effectiveness (Phase 2)Active Not RecruitingNCT04760717What this trial is testingRegulating Blood Pressure During Recovery From Intracerebral Hemorrhage and Ischemic StrokeWho this might be right forIntracerebral HemorrhageIschemic StrokeSpironolactone Yale University 160
Large-scale testing (Phase 3)UnknownNCT04424134What this trial is testingBromhexIne And Spironolactone For CoronаVirUs Infection Requiring HospiTalizationWho this might be right forCOVID 19 Lomonosov Moscow State University Medical Research and Educational Center 80
Testing effectiveness (Phase 2)Study completedNCT01371747What this trial is testingPatiromer in the Treatment of Hyperkalemia in Patients With Hypertension and Diabetic Nephropathy (AMETHYST-DN)Who this might be right forChronic Kidney DiseaseHypertensionHyperkalemia Relypsa, Inc. 324
Post-approval studies (Phase 4)Study completedNCT04676646What this trial is testingStudy to Assess Efficacy and Safety of SZC for the Management of High Potassium in Patients With Symptomatic HFrEF Receiving SpironolactoneWho this might be right forHyperkalaemiaHeart Failure With Reduced Ejection Fraction AstraZeneca 366
Testing effectiveness (Phase 2)Study completedNCT03576755What this trial is testingSpironolactone Therapy In Young Women With NASHWho this might be right forNASH - Nonalcoholic Steatohepatitis University of California, San Francisco 20
Large-scale testing (Phase 3)UnknownNCT03206658What this trial is testingSpironolactone on Acute Kidney Injury in Critically Ill PatientsWho this might be right forAcute Kidney Injury Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran 90
Testing effectiveness (Phase 2)Study completedNCT00175617What this trial is testingEfficacy of Therapy With the Spironolactone Pills Compared to Minoxidil Lotion in Female Pattern Hair LossWho this might be right forFemale Pattern Hair Loss University of British Columbia 40
Post-approval studies (Phase 4)UnknownNCT04455178What this trial is testingThe Comparison Between Spironolactone and Indapamide Monotherapy or in Combination With Amlodipine to Reduce the Risk of Heart FailureWho this might be right forHypertension Shanghai Jiao Tong University School of Medicine 200
Post-approval studies (Phase 4)Enrolling By InvitationNCT03984591What this trial is testingA Registry-based Cluster Randomized Trial to Compare the Effect of Spironolactone vs. Eplerenone on Clinical Outcomes in Patients With Symptomatic Systolic Heart FailureWho this might be right forSystolic Heart Failure Bispebjerg Hospital 7,200
Testing effectiveness (Phase 2)Looking for participantsNCT07304817What this trial is testingComparative Study on the Mode of Action of Vicadrostat and Spironolactone on Protein Profiles and Renal Hemodynamic Effects (COMPARE-VS)Who this might be right forCKDCardiovascular DiseasesHeart Failure University Medical Center Groningen 100
Large-scale testing (Phase 3)Study completedNCT06413082What this trial is testingPharmacogenetics of Torasemide and Spironolactone in Hypertension TreatmentWho this might be right forHypertensionGenetic PredispositionDrug Effect Ospedale San Raffaele 38
Post-approval studies (Phase 4)UnknownNCT05814770What this trial is testingComparing the Efficacy and Safety of Finerenone and Spironolactone in the Treatment of Primary AldosteronismWho this might be right forPrimary AldosteronismHypertension The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School 96
Not applicableStudy completedNCT04367051What this trial is testingPilot Study on Withdrawal of Spironolactone Among Heart Failure With Improved Ejection FractionWho this might be right forHeart Failure Asan Medical Center 62
Post-approval studies (Phase 4)UnknownNCT03953950What this trial is testingEffect of Add-on Spironolactone to Losartan Versus Losartan Alone on Peritoneal Membrane Among Peritoneal Dialysis PatientsWho this might be right forEnd Stage Renal DiseasePeritoneal Dialysis Chiang Mai University 84
Testing effectiveness (Phase 2)Looking for participantsNCT07041281What this trial is testingSpironolactone to Improve Pregnancy-Associated Hypertension TrajectoriesWho this might be right forPreeclampsiaGestational Hypertension Massachusetts General Hospital 204