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Results for “Symptomatic Obstructive Hypertrophic Cardiomyopathy”

36 trials

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Showing 20 of 36 results

Large-scale testing (Phase 3)Study completedNCT05186818
What this trial is testing

Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic oHCM

Who this might be right for
Obstructive Hypertrophic Cardiomyopathy (oHCM)
Cytokinetics 282
Large-scale testing (Phase 3)Study completedNCT04349072
What this trial is testing

Evaluate Mavacamten in Adults With Symptomatic Obstructive HCM Who Are Eligible for Septal Reduction Therapy

Who this might be right for
HOCM, Hypertrophic Obstructive Cardiomyopathy
Bristol-Myers Squibb 112
Testing effectiveness (Phase 2)Looking for participantsNCT07023614
What this trial is testing

A Trial to Evaluate the Efficacy and Safety of Ninerafaxstat in Patients With Symptomatic Non-obstructive Hypertrophic Cardiomyopathy

Who this might be right for
Non-obstructive Hypertrophic Cardiomyopathy
Imbria Pharmaceuticals, Inc. 165
Post-approval studies (Phase 4)Active Not RecruitingNCT06112743
What this trial is testing

Evaluate Mavacamten Impact on Myocardial Structure in Participants With Symptomatic Obstructive Hypertrophic Cardiomyopathy

Who this might be right for
Cardiomyopathy, Hypertrophic
Bristol-Myers Squibb 63
Testing effectiveness (Phase 2)Study completedNCT02842242
What this trial is testing

Open-label Pilot Study Evaluating MYK-461 in Subjects With Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction

Who this might be right for
Cardiomyopathy, Hypertrophic ObstructiveLeft Ventricular Outflow Tract Obstruction
MyoKardia, Inc. 21
Not applicableUnknownNCT05771987
What this trial is testing

Permanent Pacing for Drug-refractory Symptomatic Patients With Obstructive Hypertrophic Cardiomyopathy.

Who this might be right for
Obstructive Hypertrophic Cardiomyopathy
Istituto Auxologico Italiano 10
Large-scale testing (Phase 3)Study completedNCT05414175
What this trial is testing

Mavacamten in Obstructive Hypertrophic Cardiomyopathy

Who this might be right for
Cardiomyopathy, Hypertrophic Obstructive
Bristol-Myers Squibb 38
Testing effectiveness (Phase 2)Study completedNCT03496168
What this trial is testing

Extension Study of Mavacamten (MYK-461) in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy Previously Enrolled in PIONEER

Who this might be right for
Hypertrophic Cardiomyopathy
Bristol-Myers Squibb 13
Early research (Phase 1)Study completedNCT03767855
What this trial is testing

A Single and Multiple Ascending Dose Study of CK-3773274 in Healthy Adult Subjects

Who this might be right for
Symptomatic Obstructive Hypertrophic CardiomyopathyHealthy Subjects
Cytokinetics 114
Not applicableEnded earlyNCT06775886
What this trial is testing

Effect of Personalized Accelerated Pacing in Symptomatic Patients With Non-Obstructive Hypertrophic Cardiomyopathy

Who this might be right for
Non-obstructive Hypertrophic CardiomyopathyHypertrophic Cardiomyopathy
Montefiore Medical Center 1
Post-approval studies (Phase 4)Looking for participantsNCT07004972
What this trial is testing

Mavacamten in Adults With Obstructive Hypertrophic Cardiomyopathy in India (ROVER)

Who this might be right for
Symptomatic Obstructive Hypertrophic Cardiomyopathy
Bristol-Myers Squibb 50
Large-scale testing (Phase 3)Looking for participantsNCT06412666
What this trial is testing

Evaluate the Effect of Aficamten in Pediatric Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM).

Who this might be right for
PediatricSymptomatic Obstructive Hypertrophic Cardiomyopathy
Cytokinetics 55
Not applicableNot Yet RecruitingNCT06856265
What this trial is testing

Efficacy of Mavacamten Combined With Radiofrequency Ablation in Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy

Who this might be right for
Obstructive Hypertrophic CardiomyopathyMavacamtenRadiofrequency Ablation
Shanghai Chest Hospital 40
Large-scale testing (Phase 3)Study completedNCT05767346
What this trial is testing

Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Metoprolol Succinate in Adults With Symptomatic oHCM

Who this might be right for
Obstructive Hypertrophic Cardiomyopathy (oHCM)
Cytokinetics 175
Not applicableLooking for participantsNCT05489705
What this trial is testing

A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)

Who this might be right for
Obstructive Hypertrophic Cardiomyopathy
Bristol-Myers Squibb 1,600
Not applicableActive Not RecruitingNCT06372457
What this trial is testing

COLLIGO-HCM: A Multinational Observational Study of the Real-World Effectiveness of Mavacamten Among Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM)

Who this might be right for
Hypertrophic Cardiomyopathy (HCM)
Bristol-Myers Squibb 500
Large-scale testing (Phase 3)Study completedNCT03723655
What this trial is testing

A Long-Term Safety Extension Study of Mavacamten in Adults Who Have Completed MAVERICK-HCM or EXPLORER-HCM

Who this might be right for
Hypertrophic CardiomyopathyObstructive Hypertrophic CardiomyopathyNon-obstructive Hypertrophic Cardiomyopathy
Bristol-Myers Squibb 314
Testing effectiveness (Phase 2)Study completedNCT04219826
What this trial is testing

Dose-finding Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CK-3773274 in Adults With Hypertrophic Cardiomyopathy

Who this might be right for
Hypertrophic Cardiomyopathy (HCM)
Cytokinetics 96
Large-scale testing (Phase 3)Enrolling By InvitationNCT04848506
What this trial is testing

Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Aficamten in Adults With HCM

Who this might be right for
Symptomatic Hypertrophic Cardiomyopathy (HCM)
Cytokinetics 900
Large-scale testing (Phase 3)Active Not RecruitingNCT07023341
What this trial is testing

Learn More About How Well Aficamten Works in Japanese Participants With Symptomatic Obstructive Hypertrophic Cardiomyopathy

Who this might be right for
Obstructive Hypertrophic Cardiomyopathy
Bayer 36
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