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Results for “Systemic Immune Activation”

142 trials

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Showing 20 of 142 results

Early research (Phase 1)Study completedNCT02808793
What this trial is testing

Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AK002

Who this might be right for
Indolent Systemic Mastocytosis
Allakos Inc. 25
Testing effectiveness (Phase 2)Looking for participantsNCT03779854
What this trial is testing

Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant

Who this might be right for
Acute Biphenotypic LeukemiaAcute LeukemiaAcute Leukemia of Ambiguous Lineage+14 more
Fred Hutchinson Cancer Center 68
Not applicableNot Yet RecruitingNCT06887075
What this trial is testing

Systemic Activation of Inflammasomes and Frailty in Older Candidates to Kidney Transplantation

Who this might be right for
Chronic Kidney FailureFrailtyAging+1 more
University Hospital, Bordeaux 60
Testing effectiveness (Phase 2)Looking for participantsNCT04996875
What this trial is testing

(Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis

Who this might be right for
Advanced Systemic Mastocytosis (AdvSM)SM With an Associated Hematologic Neoplasm (SM-AHN)Mast Cell Leukemia (MCL)+1 more
Cogent Biosciences, Inc. 140
Testing effectiveness (Phase 2)Study completedNCT00367458
What this trial is testing

Randomized Placebo-Controlled Trial of Atorvastatin in HIV-Positive Patients Not on Antiretroviral Therapy

Who this might be right for
HIV
National Institute of Allergy and Infectious Diseases (NIAID) 24
Testing effectiveness (Phase 2)Study completedNCT00109707
What this trial is testing

Oral AMN107 in Adults With Chronic Myelogenous Leukemia (CML) or Other Hematologic Malignancies

Who this might be right for
Chronic Myelogenous LeukemiaAcute Lymphoblastic Leukemia (Philadelphia Chromosome Positive)Hypereosinophilic Syndrome+1 more
Novartis Pharmaceuticals 507
Large-scale testing (Phase 3)Study completedNCT00666211
What this trial is testing

Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain

Who this might be right for
Brain and Central Nervous System TumorsChronic Myeloproliferative DisordersLeukemia+8 more
Vanderbilt-Ingram Cancer Center 98
Not applicableStudy completedNCT02188992
What this trial is testing

Early PREdiction of Severe Sepsis I (ExPRES-Sepsis I) Study

Who this might be right for
Sepsis
University of Edinburgh 401
Not applicableStudy completedNCT02380222
What this trial is testing

Patient-Reported Outcome Questionnaire for Systemic Mastocytosis

Who this might be right for
Aggressive Systemic Mastocytosis (ASM)SM w Assoc Clonal Hema Non-mast Cell Lineage Disease (SM-AHNMD)Mast Cell Leukemia (MCL)+2 more
Adelphi Values LLC 5
Testing effectiveness (Phase 2)Study completedNCT03770273
What this trial is testing

Safety and Efficacy of Subcutaneous Sarilumab in Improving the Quality of Life in People With Indolent Systemic Mastocytosis

Who this might be right for
Indolent Systemic Mastocytosis
National Institute of Allergy and Infectious Diseases (NIAID) 21
Not applicableLooking for participantsNCT01137643
What this trial is testing

Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic Cancer

Who this might be right for
Chronic Myeloproliferative DisordersLeukemiaLymphoma+5 more
UNC Lineberger Comprehensive Cancer Center 15,000
Testing effectiveness (Phase 2)Study completedNCT00493129
What this trial is testing

Ontak (Denileukin Diftitox) in Patients With Systemic Mastocytosis (SM)

Who this might be right for
LeukemiaSystemic Mastocytosis
M.D. Anderson Cancer Center 8
Large-scale testing (Phase 3)UnknownNCT05084872
What this trial is testing

Hydroxychloroquine in Isolated Cutaneous Mastocytosis Patients or Indolent Systemic Mastocytosis With Associated Skin Involvement Patients

Who this might be right for
Mastocytosis
University Hospital, Toulouse 30
Post-approval studies (Phase 4)Study completedNCT01297777
What this trial is testing

Imatinib in KIT-negative Systemic Mastocytosis

Who this might be right for
Systemic Mastocytosis
Hospital Virgen de la Salud 10
Early research (Phase 1)Study completedNCT02561988
What this trial is testing

(EXPLORER) Study of BLU-285 in Patients With Advanced Systemic Mastocytosis (AdvSM) and Relapsed or Refractory Myeloid Malignancies

Who this might be right for
Aggressive Systemic MastocytosisSystemic Mastocytosis-associated Hematologic Non-mast Cell DiseaseMast Cell Leukemia+1 more
Blueprint Medicines Corporation 86
Testing effectiveness (Phase 2)Ended earlyNCT02415608
What this trial is testing

Ibrutinib in Treating Patients With Advanced Systemic Mastocytosis

Who this might be right for
Aggressive Systemic MastocytosisMast Cell LeukemiaSystemic Mastocytosis
Jason Robert Gotlib 4
Early research (Phase 1)Study completedNCT02571036
What this trial is testing

A Safety, Tolerability and PK Study of DCC-2618 in Patients With Advanced Malignancies

Who this might be right for
Gastrointestinal Stromal TumorsAdvanced Systemic MastocytosisAdvanced Cancers
Deciphera Pharmaceuticals, LLC 282
Not applicableUnknownNCT06013683
What this trial is testing

A Registry for Patients With Systemic Mastocytosis in China

Who this might be right for
Systemic Mastocytoses
The First Affiliated Hospital of Soochow University 150
Not applicableWithdrawnNCT00378781
What this trial is testing

Heparin or M-EDTA in Preventing Catheter-Related Infections and Blockages in Patients at High Risk for a Catheter-Related Infection

Who this might be right for
Cancer
M.D. Anderson Cancer Center
Testing effectiveness (Phase 2)WithdrawnNCT03739606
What this trial is testing

Flotetuzumab in Treating Patients With Recurrent or Refractory CD123 Positive Blood Cancer

Who this might be right for
Acute Biphenotypic LeukemiaAcute LeukemiaChronic Myelogenous Leukemia, BCR-ABL1 Positive+12 more
City of Hope Medical Center
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