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Results for “T Cell Receptor Alpha/Beta Depletion”

17 trials

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Showing 17 of 17 results

Testing effectiveness (Phase 2)Looking for participantsNCT04414046
What this trial is testing

TCR Alpha Beta T-cell Depleted Haploidentical HCT in the Treatment of Primary Immunodeficiency and Inherited Metabolic Disorders in Children

Who this might be right for
Primary Immune Deficiency DisordersMetabolic Disease
Johns Hopkins All Children's Hospital 17
Not applicableActive Not RecruitingNCT05236764
What this trial is testing

Haploidentical Hematopoietic Cell Transplantation Using TCR Alpha/Beta and CD19 Depletion

Who this might be right for
Acute Lymphoblastic Leukemia in RemissionAcute Myeloid Leukemia in RemissionMyelodysplastic Syndromes+8 more
Baylor College of Medicine 3
Testing effectiveness (Phase 2)WithdrawnNCT05288595
What this trial is testing

TCR Alpha/Beta and CD19-deplete Haplo-HSCT

Who this might be right for
Pediatric PatientsHematologic MalignancyOther Hematologic Condition
University of Colorado, Denver
Large-scale testing (Phase 3)Study completedNCT02942173
What this trial is testing

CD45RA Depleted T-cell Infusion for Prevention of Infections After TCRab/CD19-depleted Allo-HSCT

Who this might be right for
LeukemiaLymphomaMyelodysplastic Syndromes+3 more
Federal Research Institute of Pediatric Hematology, Oncology and Immunology 150
Testing effectiveness (Phase 2)Ended earlyNCT03615144
What this trial is testing

TCR Alpha Beta T-cell and CD19 B-cell Depleted Peripheral Blood Stem Cell Transplantation Using the CliniMACS System for Patients With Non-Malignant Hematologic Disorders From Matched or Mismatched, Related or Unrelated Donors

Who this might be right for
Non-Malignant Hematologic Disorders
Memorial Sloan Kettering Cancer Center 1
Testing effectiveness (Phase 2)UnknownNCT03019809
What this trial is testing

A Trial of Plerixafor/G-CSF as Additional Agents for Conditioning Before TCR Alpha/Beta Depleted HSCT in WAS Patients

Who this might be right for
Wiskott-Aldrich SyndromeHematopoietic Stem Cell TransplantationGraft Failure
Federal Research Institute of Pediatric Hematology, Oncology and Immunology 30
Testing effectiveness (Phase 2)Study completedNCT02337595
What this trial is testing

Memory T-cell Infusion to Improve Immunity After TCR-alpha/Beta Depleted Hematopoietic Stem Cell Transplantation

Who this might be right for
Precursor T-Cell Lymphoblastic Leukemia-LymphomaLeukemia, Myeloid, AcuteImmune Deficiency Disease+3 more
Federal Research Institute of Pediatric Hematology, Oncology and Immunology 30
Testing effectiveness (Phase 2)Looking for participantsNCT04746209
What this trial is testing

Blinatumomab After TCR Alpha Beta/CD19 Depleted HCT

Who this might be right for
B-cell Acute Lymphoblastic LeukemiaB-cell Childhood Acute Lymphoblastic LeukemiaB-Cell ALL, Childhood
Medical College of Wisconsin 25
Testing effectiveness (Phase 2)Looking for participantsNCT04356469
What this trial is testing

TCR Alpha Beta T-cell Depleted Haploidentical HCT in the Treatment of Non-Malignant Hematological Disorders in Children

Who this might be right for
Hemoglobinopathy (Disorder)Severe Aplastic AnemiaBone Marrow Failure Syndrome
Johns Hopkins All Children's Hospital 17
Testing effectiveness (Phase 2)Looking for participantsNCT05735717
What this trial is testing

MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies

Who this might be right for
Hematologic MalignancyAcute LeukemiaRemission+21 more
Masonic Cancer Center, University of Minnesota 70
Early research (Phase 1)WithdrawnNCT03939585
What this trial is testing

Preemptive Infusion of Donor Lymphocytes Depleted of TCR + T Cells + CD19+ B Cells Following ASCT

Who this might be right for
Allogeneic Stem Cell Transplant CandidateAcute Myeloid/Lymphoblastic LeukemiaMyelodysplastic Syndrome+2 more
Leland Metheny
Testing effectiveness (Phase 2)Looking for participantsNCT03579875
What this trial is testing

Alpha/Beta TCD HCT in Patients With Inherited BMF Disorders

Who this might be right for
Fanconi AnemiaSevere Aplastic AnemiaMyelodysplastic Syndromes+5 more
Masonic Cancer Center, University of Minnesota 48
Early research (Phase 1)Looking for participantsNCT02508038
What this trial is testing

Alpha/Beta CD19+ Depleted Haploidentical Transplantation + Zometa for Pediatric Hematologic Malignancies and Solid Tumors

Who this might be right for
Acute Myeloid LeukemiaAcute Lymphoblastic LeukemiaHodgkin Lymphoma+8 more
University of Wisconsin, Madison 22
Testing effectiveness (Phase 2)Active Not RecruitingNCT03301168
What this trial is testing

Study of Gene Modified Donor T-cells Following TCR Alpha Beta Positive Depleted Stem Cell Transplant

Who this might be right for
Acute Lymphoblastic LeukemiaLeukemia, Acute Myeloid (AML), ChildLymphoma, Non-Hodgkin+6 more
Bellicum Pharmaceuticals 120
Large-scale testing (Phase 3)Study completedNCT02327351
What this trial is testing

TCR Alpha/Beta Depletion for HSCT From Haploidentical and Unrelated Donors in the Treatment of PID

Who this might be right for
Primary Immune Deficiency DisorderHematopoietic Stem Cell Transplantation
Federal Research Institute of Pediatric Hematology, Oncology and Immunology 98
Early research (Phase 1)Looking for participantsNCT05011422
What this trial is testing

Haploidentical Hematopoietic Stem Cell Transplantation With Ex Vivo TCR Alpha/Beta and CD19 Depletion in Pediatric Hematologic Malignancies

Who this might be right for
Pediatric Hematologic Malignancies
Washington University School of Medicine 50
Not applicableAvailableNCT03145545
What this trial is testing

Expanded Access Protocol Using Alpha/Beta T and CD19+ Depleted PBSC

Who this might be right for
LeukemiaBone Marrow Failure SyndromeImmunodeficiencies
Children's Hospital of Philadelphia