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Results for “TP53”

196 trials

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Showing 20 of 196 results

Testing effectiveness (Phase 2)Not Yet RecruitingNCT05280626
What this trial is testing

First-line Treatment of P53 Mutation With PD-L1 Expression in DLBCL With Anti-PD-1 Mab and R-CHOP

Who this might be right for
Diffuse Large B-Cell Lymphoma
Innovent Biologics (Suzhou) Co. Ltd. 100
Early research (Phase 1)Looking for participantsNCT06908434
What this trial is testing

A Phase I First-in-Human Study of GenSci128 in Patients With Solid Tumors Harboring a TP53 Y220C Mutation

Who this might be right for
Solid Tumors Harboring a TP53 Y220C Mutation
Changchun GeneScience Pharmaceutical Co., Ltd. 82
Testing effectiveness (Phase 2)Looking for participantsNCT06366347
What this trial is testing

ALPINE: Maintenance Letrozole/Abemaciclib

Who this might be right for
Endometrial CancerRecurrent Endometrial CancerTP53
Dana-Farber Cancer Institute 32
Testing effectiveness (Phase 2)Looking for participantsNCT06517511
What this trial is testing

Selinexor in Combination With R-CHOP as the First-line Therapy for TP53-mutated DLBCL Patients (Smart Trial)

Who this might be right for
Diffuse Large B Cell Lymphoma
Sun Yat-sen University 42
Not applicableStudy completedNCT01954134
What this trial is testing

P53 in Differentiated Thyroid Cancer

Who this might be right for
Thyroid Neoplasms
Cumhuriyet University 199
Testing effectiveness (Phase 2)Looking for participantsNCT04585750
What this trial is testing

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

Who this might be right for
Advanced Solid TumorAdvanced Malignant NeoplasmMetastatic Cancer+27 more
PMV Pharmaceuticals, Inc 300
Testing effectiveness (Phase 2)Active Not RecruitingNCT05491811
What this trial is testing

Ensartinib in Combination With Bevacizumab in ALK-positive NSCLC Patients With TP53 Mutation

Who this might be right for
Non-Small Cell Lung Cancer
Sun Yat-sen University 49
Early research (Phase 1)Looking for participantsNCT05631886
What this trial is testing

Combination of CAR-DC Vaccine and ICIs in Malignant Tumors

Who this might be right for
Solid Tumor, AdultLymphomaEphA2 Overexpression+4 more
Chinese PLA General Hospital 10
Testing effectiveness (Phase 2)Study completedNCT01164995
What this trial is testing

Study With Wee-1 Inhibitor AZD1775 (MK-1775) and Carboplatin to Treat p53 Mutated Refractory and Resistant Ovarian Cancer

Who this might be right for
Epithelial Ovarian Cancer
The Netherlands Cancer Institute 24
Testing effectiveness (Phase 2)WithdrawnNCT00967512
What this trial is testing

Aezea® (Cenersen) and Chemotherapy for AML Subjects ≥ 55 Years of Age With No Response to Frontline Induction Course

Who this might be right for
Acute Myelogenous Leukemia
Eleos, Inc.
Early research (Phase 1)Looking for participantsNCT06795009
What this trial is testing

Zanzalintinib in Combination With Paclitaxel in Recurrent High Grade Uterine Cancer

Who this might be right for
Uterine CancerEndometrial Cancer
Washington University School of Medicine 36
Testing effectiveness (Phase 2)Looking for participantsNCT02734537
What this trial is testing

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

Who this might be right for
Head and Neck Squamous Cell CarcinomaHypopharyngeal Squamous Cell CarcinomaLaryngeal Squamous Cell Carcinoma+13 more
ECOG-ACRIN Cancer Research Group 189
Large-scale testing (Phase 3)Study completedNCT00017095
What this trial is testing

Biomarker (p53 Gene) Analysis and Combination Chemotherapy Followed by Radiation Therapy and Surgery in Treating Women With Large Operable or Locally Advanced or Inflammatory Breast Cancer

Who this might be right for
Breast Cancer
European Organisation for Research and Treatment of Cancer - EORTC 1,856
Early research (Phase 1)Active Not RecruitingNCT03725436
What this trial is testing

ALRN-6924 and Paclitaxel in Treating Patients With Advanced, Metastatic, or Unresectable Solid Tumors

Who this might be right for
Advanced Malignant Solid NeoplasmAnatomic Stage III Breast Cancer AJCC v8Anatomic Stage IIIA Breast Cancer AJCC v8+12 more
M.D. Anderson Cancer Center 35
Not applicableLooking for participantsNCT07242963
What this trial is testing

Relapsed and Progressive Sonic Hedgehog Medulloblastoma With U1 Mutation Registry Study

Who this might be right for
Medulloblastoma RecurrentMedulloblastoma, Childhood, RecurrentMedulloblastoma, SHH-activated and TP53 Mutant+1 more
Mohammad H. Abu Arja 300
Early research (Phase 1)Ended earlyNCT05155709
What this trial is testing

Siremadlin in Combination With Venetoclax Plus Azacitidine in Adult Participants With Acute Myeloid Leukemia (AML) Who Are Ineligible for Chemotherapy.

Who this might be right for
Acute Myeloid Leukemia
Novartis Pharmaceuticals 14
Not applicableUnknownNCT03927599
What this trial is testing

Advanced Refractory Solid Tumors With TP53 Mutations Register Study

Who this might be right for
Solid Tumor, Adult
Tianjin Medical University Second Hospital 100
Testing effectiveness (Phase 2)UnknownNCT03787602
What this trial is testing

Navtemadlin (KRT-232) With or Without Anti-PD-1/Anti-PD-L1 for the Treatment of Patients With Merkel Cell Carcinoma

Who this might be right for
Merkel Cell Carcinoma
Kartos Therapeutics, Inc. 115
Early research (Phase 1)UnknownNCT03645200
What this trial is testing

Treatment of Carrying TP53 Harmful Mutations

Who this might be right for
Advanced Cancer
Tianjin Medical University Second Hospital 60
Not applicableStudy completedNCT02309567
What this trial is testing

Is There Any Relation Between Serum Anti-p53 Antibody and TLG, MTV and SUV as PET Parameters in Lung Cancer Patients?

Who this might be right for
Lung NeoplasmsGene, p53
Cumhuriyet University 146
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