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Results for “TP53”

212 trials

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Showing 20 of 212 results

Early research (Phase 1)UnknownNCT03645200
What this trial is testing

Treatment of Carrying TP53 Harmful Mutations

Who this might be right for
Advanced Cancer
Tianjin Medical University Second Hospital 60
Large-scale testing (Phase 3)Looking for participantsNCT05197192
What this trial is testing

A Phase-3-trial of Acalabrutinib, Obinutuzumab & Venetoclax Compared to Obinutuzumab and Venetoclax in Previously Untreated Patients With High Risk CLL

Who this might be right for
Chronic Lymphocytic Leukemia
German CLL Study Group 202
Large-scale testing (Phase 3)Study completedNCT02756611
What this trial is testing

Evaluate the Efficacy of Venetoclax Monotherapy in Relapsed/Refractory Participants With Chronic Lymphocytic Leukemia (CLL)

Who this might be right for
Chronic Lymphocytic Leukemia
AbbVie 258
Testing effectiveness (Phase 2)Looking for participantsNCT02734537
What this trial is testing

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

Who this might be right for
Head and Neck Squamous Cell CarcinomaHypopharyngeal Squamous Cell CarcinomaLaryngeal Squamous Cell Carcinoma+13 more
ECOG-ACRIN Cancer Research Group 189
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07569965
What this trial is testing

Frontline Risk-Adapted Optimization of Novel Targeted Immunotherapy Evaluation in High-Risk MCL

Who this might be right for
Mantle Cell Lymphoma (MCL)
Miltenyi Biomedicine GmbH 52
Testing effectiveness (Phase 2)UnknownNCT03226301
What this trial is testing

A Prospective, Multicenter, Phase-II Trial of Ibrutinib Plus Venetoclax in Patients With Creatinine Clearance >= 30 ml/Min Who Have Relapsed or Refractory Chronic Lymphocytic Leukemia (RR-CLL) With or Without TP53 Aberrations

Who this might be right for
Chronic Lymphocytic Leukemia in RelapseChronic Lymphocytic Leukemia in Remission
Stichting Hemato-Oncologie voor Volwassenen Nederland 230
Not applicableLooking for participantsNCT04367246
What this trial is testing

Li-Fraumeni Syndrome/TP53 Biobank

Who this might be right for
Li-Fraumeni SyndromeLi-Fraumeni-Like Syndrome
Abramson Cancer Center at Penn Medicine 300
Testing effectiveness (Phase 2)Study completedNCT00617409
What this trial is testing

To Immunize Patients With Extensive Stage SCLC Combined With Chemo With or Without All Trans Retinoic Acid

Who this might be right for
Small Cell Lung Cancer
H. Lee Moffitt Cancer Center and Research Institute 69
Large-scale testing (Phase 3)Study completedNCT03745716
What this trial is testing

APR-246 & Azacitidine for the Treatment of TP53 Mutant Myelodysplastic Syndromes (MDS)

Who this might be right for
MDS
Aprea Therapeutics 154
Early research (Phase 1)Not Yet RecruitingNCT07737769
What this trial is testing

Arsenic Trioxide to Prevent Relapse in Patients Undergoing Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia or Myelodysplastic Syndrome

Who this might be right for
Acute Myeloid LeukemiaMyelodysplastic Syndrome
University of Michigan Rogel Cancer Center 20
Testing effectiveness (Phase 2)Study completedNCT02448329
What this trial is testing

Study of AZD1775 in Combination With Paclitaxel, in Advanced Gastric Adenocarcinoma Patients Harboring TP53 Mutation as a Second-line Chemotherapy

Who this might be right for
Advanced Gastric Adenocarcinoma
Samsung Medical Center 26
Testing effectiveness (Phase 2)Looking for participantsNCT06005870
What this trial is testing

Zanubrutinib Combined With R-CHOP in the Treatment of Newly Diagnosed DLBCL With p53 Protein Expression

Who this might be right for
Diffuse Large B Cell Lymphoma
Huazhong University of Science and Technology 41
Early research (Phase 1)Active Not RecruitingNCT03567642
What this trial is testing

The Combination of Osimertinib, Platinum and Etoposide for Patients With Metastatic EGFR Mutant Lung Cancers

Who this might be right for
Lung Cancer
Memorial Sloan Kettering Cancer Center 11
Testing effectiveness (Phase 2)UnknownNCT02561546
What this trial is testing

P53 Gene Therapy in Treatment of Diabetes Concurrent With Hepatocellular Carcinoma

Who this might be right for
HCCDiabetes
Shenzhen SiBiono GeneTech Co.,Ltd 40
Early research (Phase 1)Study completedNCT04293094
What this trial is testing

Study of AMG 650 in Adult Participants With Advanced Solid Tumors

Who this might be right for
Advanced Solid Tumors
Volastra Therapeutics, Inc. 66
Not applicableLooking for participantsNCT06791941
What this trial is testing

Study of the Contribution of Mutant p53/YAP Proteins to Therapy Resistance in Recurrent Head and Neck Cancer

Who this might be right for
Head and Neck Tumors
Regina Elena Cancer Institute 18
Testing effectiveness (Phase 2)Study completedNCT00049218
What this trial is testing

Chemotherapy Followed By Vaccine Therapy in Treating Patients With Extensive-Stage Small Cell Lung Cancer

Who this might be right for
Lung Cancer
H. Lee Moffitt Cancer Center and Research Institute 56
Testing effectiveness (Phase 2)Looking for participantsNCT06158399
What this trial is testing

AZA Combined With RCHOP in P53-mutated DLBCL.

Who this might be right for
DLBCL - Diffuse Large B Cell LymphomaTP53
The First Affiliated Hospital of Xiamen University 52
Large-scale testing (Phase 3)Ended earlyNCT04159155
What this trial is testing

Various Treatments in Serous or p53 Abnormal Endometrial Cancer

Who this might be right for
Endometrial CarcinomaP53 MutationSerous Carcinoma
University Health Network, Toronto 11
Large-scale testing (Phase 3)WithdrawnNCT06370871
What this trial is testing

Brightline-3: A Study to Find Out Whether Brigimadlin in Combination With Ezabenlimab Helps People With Advanced Soft Tissue Sarcoma

Who this might be right for
Advanced Soft Tissue SarcomaUndifferentiated Pleomorphic Sarcoma (UPS)Myxofibrosarcoma (MFS)
Boehringer Ingelheim
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