Testing effectiveness (Phase 2)Ended earlyNCT02612285What this trial is testingStudy of SNX-5422 in TP53 Null CancersWho this might be right forCancer Esanex Inc. 1
Early research (Phase 1)Study completedNCT06054464What this trial is testingInvestigate the Effects of Acid Reducing Agents on Pharmacokinetics of PC14586 in Healthy ParticipantsWho this might be right forHealthy Volunteers PMV Pharmaceuticals, Inc 28
Not applicableNot Yet RecruitingNCT06900582What this trial is testingSENTInel Node Mapping Versus Comprehensive Lymphadenectomy in p53-Mutated Endometrial Cancer: A Non-Inferiority Randomized TrialWho this might be right forLymphadenectomyEndometrial CancerGene, p53+1 more University Hospital, Strasbourg, France 374
Early research (Phase 1)Ended earlyNCT03940352What this trial is testingHDM201 in Combination With MBG453 or Venetoclax in Patients With Acute Myeloid Leukemia (AML) or High-risk Myelodysplastic Syndrome (MDS)Who this might be right forAcute Myeloid Leukemia (AML)High-risk Myelodysplastic Syndrome (MDS) Novartis Pharmaceuticals 52
Not applicableActive Not RecruitingNCT07303218What this trial is testingThe HER Project: HRD in EGFR-mutated NSCLCWho this might be right forEGFRNon Small Cell Lung CancerHomologous Recombination Deficiency+1 more IRCCS San Raffaele 100
Testing effectiveness (Phase 2)Active Not RecruitingNCT02965950What this trial is testingThe p53 Breast Cancer TrialWho this might be right forLocally Advanced Breast CancerMetastatic Breast Carcinoma Haukeland University Hospital 190
Testing effectiveness (Phase 2)UnknownNCT04358393What this trial is testingAPG-115 Alone or Combined With Azacitidine in Patients With AML, CMML, or MDSWho this might be right forAMLAcute Myeloid LeukemiaChronic Myelomonocytic Leukemia+4 more Ascentage Pharma Group Inc. 69
Not applicableUnknownNCT03524677What this trial is testingMutation of K-RAS, CDKN2A, SMAD4 and TP53 in Pancreatic Cancer: Role of Liquid Biopsy in Preoperative DiagnosisWho this might be right forPancreatic Cancer University of Roma La Sapienza 50
Not applicableStudy completedNCT04872036What this trial is testingPrognostic Biomarkers in Patients With Urothelial CarcinomaWho this might be right forBladder Cancer Hellenic Cooperative Oncology Group 66
Testing effectiveness (Phase 2)Study completedNCT01164995What this trial is testingStudy With Wee-1 Inhibitor AZD1775 (MK-1775) and Carboplatin to Treat p53 Mutated Refractory and Resistant Ovarian CancerWho this might be right forEpithelial Ovarian Cancer The Netherlands Cancer Institute 24
Not applicableStudy completedNCT02827617What this trial is testingIdentification of Biomarkers That Are Predictive of Early Ibrutinib Treatment Failure in High Risk TP53 Mutated Chronic Lymphocytic LeukemiaWho this might be right forChronic Lymphocytic Leukemia Oncology Institute of Southern Switzerland 56
Not applicableNot Yet RecruitingNCT06521684What this trial is testingTranslational Study of MSS, TP53 Mutation and Chromosome Instability Relationship in Endometrial CarcinomaWho this might be right forEndometrial NeoplasmsTP53 Gene MutationChromosomal Instability+1 more Peking Union Medical College Hospital 110
Testing effectiveness (Phase 2)UnknownNCT04533321What this trial is testingA Biomarker-implemented Clinical Study Evaluating Mutations in MET and TP53 in a Population of Treatment-refractory Squamous Cell CarcinomaWho this might be right forSquamous Cell Carcinoma National University Hospital, Singapore 20
Large-scale testing (Phase 3)Study completedNCT02756611What this trial is testingEvaluate the Efficacy of Venetoclax Monotherapy in Relapsed/Refractory Participants With Chronic Lymphocytic Leukemia (CLL)Who this might be right forChronic Lymphocytic Leukemia AbbVie 258
Testing effectiveness (Phase 2)Not Yet RecruitingNCT05778149What this trial is testingSafety and Efficacy of Aumolertinib Combined With Anlotinib as 1st Line Treatment in Advanced Lung Cancer EGFR Mutation With TP53 Co-MutationWho this might be right forAumolertinibAnlotinibTP53+2 more Tianjin Medical University Cancer Institute and Hospital 47
Testing effectiveness (Phase 2)UnknownNCT03588078What this trial is testingStudy of the Safety and Efficacy of APR-246 in Combination With AzacitidineWho this might be right forMyelodysplastic Syndrome With Gene MutationAcute Myeloid Leukemia With Gene MutationsMyeloproliferative Neoplasm+1 more Groupe Francophone des Myelodysplasies 53
Not applicableStudy completedNCT01737255What this trial is testingMagnetic Resonance Imaging Screening in Li Fraumeni SyndromeWho this might be right forLi-Fraumeni Syndrome Institute of Cancer Research, United Kingdom 88
Large-scale testing (Phase 3)Ended earlyNCT04159155What this trial is testingVarious Treatments in Serous or p53 Abnormal Endometrial CancerWho this might be right forEndometrial CarcinomaP53 MutationSerous Carcinoma University Health Network, Toronto 11
Not applicableLooking for participantsNCT04367246What this trial is testingLi-Fraumeni Syndrome/TP53 BiobankWho this might be right forLi-Fraumeni SyndromeLi-Fraumeni-Like Syndrome Abramson Cancer Center at Penn Medicine 300
Early research (Phase 1)Ended earlyNCT04477291What this trial is testingCG-806 in Patients With Relapsed or Refractory AML or Higher-Risk MDSWho this might be right forAcute Myeloid LeukemiaMyelodysplastic Syndromes Aptose Biosciences Inc. 45