Early research (Phase 1)UnknownNCT03645200What this trial is testingTreatment of Carrying TP53 Harmful MutationsWho this might be right forAdvanced Cancer Tianjin Medical University Second Hospital 60
Large-scale testing (Phase 3)Looking for participantsNCT05197192What this trial is testingA Phase-3-trial of Acalabrutinib, Obinutuzumab & Venetoclax Compared to Obinutuzumab and Venetoclax in Previously Untreated Patients With High Risk CLLWho this might be right forChronic Lymphocytic Leukemia German CLL Study Group 202
Large-scale testing (Phase 3)Study completedNCT02756611What this trial is testingEvaluate the Efficacy of Venetoclax Monotherapy in Relapsed/Refractory Participants With Chronic Lymphocytic Leukemia (CLL)Who this might be right forChronic Lymphocytic Leukemia AbbVie 258
Testing effectiveness (Phase 2)Looking for participantsNCT02734537What this trial is testingRadiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone SurgeryWho this might be right forHead and Neck Squamous Cell CarcinomaHypopharyngeal Squamous Cell CarcinomaLaryngeal Squamous Cell Carcinoma+13 more ECOG-ACRIN Cancer Research Group 189
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07569965What this trial is testingFrontline Risk-Adapted Optimization of Novel Targeted Immunotherapy Evaluation in High-Risk MCLWho this might be right forMantle Cell Lymphoma (MCL) Miltenyi Biomedicine GmbH 52
Testing effectiveness (Phase 2)UnknownNCT03226301What this trial is testingA Prospective, Multicenter, Phase-II Trial of Ibrutinib Plus Venetoclax in Patients With Creatinine Clearance >= 30 ml/Min Who Have Relapsed or Refractory Chronic Lymphocytic Leukemia (RR-CLL) With or Without TP53 AberrationsWho this might be right forChronic Lymphocytic Leukemia in RelapseChronic Lymphocytic Leukemia in Remission Stichting Hemato-Oncologie voor Volwassenen Nederland 230
Not applicableLooking for participantsNCT04367246What this trial is testingLi-Fraumeni Syndrome/TP53 BiobankWho this might be right forLi-Fraumeni SyndromeLi-Fraumeni-Like Syndrome Abramson Cancer Center at Penn Medicine 300
Large-scale testing (Phase 3)Study completedNCT03745716What this trial is testingAPR-246 & Azacitidine for the Treatment of TP53 Mutant Myelodysplastic Syndromes (MDS)Who this might be right forMDS Aprea Therapeutics 154
Early research (Phase 1)Not Yet RecruitingNCT07737769What this trial is testingArsenic Trioxide to Prevent Relapse in Patients Undergoing Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia or Myelodysplastic SyndromeWho this might be right forAcute Myeloid LeukemiaMyelodysplastic Syndrome University of Michigan Rogel Cancer Center 20
Testing effectiveness (Phase 2)Study completedNCT02448329What this trial is testingStudy of AZD1775 in Combination With Paclitaxel, in Advanced Gastric Adenocarcinoma Patients Harboring TP53 Mutation as a Second-line ChemotherapyWho this might be right forAdvanced Gastric Adenocarcinoma Samsung Medical Center 26
Early research (Phase 1)Active Not RecruitingNCT03567642What this trial is testingThe Combination of Osimertinib, Platinum and Etoposide for Patients With Metastatic EGFR Mutant Lung CancersWho this might be right forLung Cancer Memorial Sloan Kettering Cancer Center 11
Early research (Phase 1)Study completedNCT04293094What this trial is testingStudy of AMG 650 in Adult Participants With Advanced Solid TumorsWho this might be right forAdvanced Solid Tumors Volastra Therapeutics, Inc. 66
Not applicableLooking for participantsNCT06791941What this trial is testingStudy of the Contribution of Mutant p53/YAP Proteins to Therapy Resistance in Recurrent Head and Neck CancerWho this might be right forHead and Neck Tumors Regina Elena Cancer Institute 18
Testing effectiveness (Phase 2)Looking for participantsNCT06158399What this trial is testingAZA Combined With RCHOP in P53-mutated DLBCL.Who this might be right forDLBCL - Diffuse Large B Cell LymphomaTP53 The First Affiliated Hospital of Xiamen University 52
Large-scale testing (Phase 3)Ended earlyNCT04159155What this trial is testingVarious Treatments in Serous or p53 Abnormal Endometrial CancerWho this might be right forEndometrial CarcinomaP53 MutationSerous Carcinoma University Health Network, Toronto 11
Large-scale testing (Phase 3)WithdrawnNCT06370871What this trial is testingBrightline-3: A Study to Find Out Whether Brigimadlin in Combination With Ezabenlimab Helps People With Advanced Soft Tissue SarcomaWho this might be right forAdvanced Soft Tissue SarcomaUndifferentiated Pleomorphic Sarcoma (UPS)Myxofibrosarcoma (MFS) Boehringer Ingelheim
Testing effectiveness (Phase 2)UnknownNCT03381781What this trial is testingDecitabine,Cytarabine and Arsenic Trioxide for Acute Myeloid Leukemia With p53 MutationsWho this might be right forAcute Myeloid LeukemiaP53 Mutation Li Junmin 100
Large-scale testing (Phase 3)UnknownNCT04123392What this trial is testingDecitabine + BUCY vs BUCY Conditioning Regimen for TP53+ Myeloid Tumors Undergoing Allo-HSCTWho this might be right forTP53Myeloid TumorsConditioning+1 more Nanfang Hospital, Southern Medical University 196
Early research (Phase 1)Looking for participantsNCT06778863What this trial is testingCLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H MutationWho this might be right forAdvanced Solid TumorUnresectable Solid TumorMetastatic Solid Tumor+8 more Clasp Therapeutics, Inc. 90
Not applicableStudy completedNCT02171286What this trial is testingThe Oncopanel Pilot (TOP) StudyWho this might be right forColorectal Cancer MetastaticAdvanced Non-Small Cell Lung CarcinomaAdvanced Melanoma+2 more British Columbia Cancer Agency 432