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Results for “TP53 Gene Mutation”

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Showing 20 of 0 results

Testing effectiveness (Phase 2)Looking for participantsNCT05735717
What this trial is testing

MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies

Who this might be right for
Hematologic MalignancyAcute LeukemiaRemission+21 more
Masonic Cancer Center, University of Minnesota 70
Testing effectiveness (Phase 2)Ended earlyNCT03149679
What this trial is testing

The p53 Colorectal Cancer Trial

Who this might be right for
Colorectal Cancer MetastaticColorectal Cancer Stage IVTP53 Gene Mutation
Haukeland University Hospital 12
Early research (Phase 1)Looking for participantsNCT05877599
What this trial is testing

NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

Who this might be right for
Non-small Cell Lung CancerHead and Neck Squamous Cell CarcinomaColorectal Carcinoma+5 more
AstraZeneca 45
Testing effectiveness (Phase 2)Study completedNCT02797977
What this trial is testing

A Phase 1/2 Trial SRA737 in Combination With Gemcitabine and Cisplatin or Gemcitabine Alone in Advanced Cancer Subjects

Who this might be right for
Advanced Solid Tumors
Sierra Oncology LLC - a GSK company 153
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07752875
What this trial is testing

LG00313112 in Participants With Advanced Solid Malignancies Harboring a TP53 Y220C Mutation

Who this might be right for
Ovarian CancerSmall Cell Lung CancerNon Small Cell Lung Cancer+7 more
LG Chem 250
Not applicableLooking for participantsNCT04541654
What this trial is testing

Li-Fraumeni & TP53 (LiFT UP): Understanding and Progress

Who this might be right for
Li-Fraumeni SyndromeTP53 Gene MutationHereditary Cancer Syndrome+2 more
Dana-Farber Cancer Institute 1,500
Testing effectiveness (Phase 2)Study completedNCT01357161
What this trial is testing

Adavosertib (MK-1775) in Combination With Paclitaxel and Carboplatin Versus Paclitaxel and Carboplatin Alone for Participants With Platinum-Sensitive Ovarian Tumors With the P53 Gene Mutation (MK-1775-004)

Who this might be right for
Ovarian Cancer
Merck Sharp & Dohme LLC 136
Early research (Phase 1)Ended earlyNCT04638309
What this trial is testing

APR-548 in Combination With Azacitidine for the Treatment of TP53 Myelodysplastic Syndromes (MDS)

Who this might be right for
MDSMyelodysplastic Syndromes
Aprea Therapeutics 4
Testing effectiveness (Phase 2)Looking for participantsNCT06517511
What this trial is testing

Selinexor in Combination With R-CHOP as the First-line Therapy for TP53-mutated DLBCL Patients (Smart Trial)

Who this might be right for
Diffuse Large B Cell Lymphoma
Sun Yat-sen University 42
Testing effectiveness (Phase 2)Looking for participantsNCT06778187
What this trial is testing

Oral-ATO for TP53-mutated Myeloid Malignancies

Who this might be right for
Acute Myeloid LeukemiaMyelodysplastic NeoplasmChronic Myelomonocytic Leukemia+2 more
The University of Hong Kong 30
Testing effectiveness (Phase 2)UnknownNCT04023916
What this trial is testing

Sintilimab Plus R-CHOP as the First-line Treatment in Patients With Diffuse Large B-Cell Lymphoma.

Who this might be right for
Diffuse Large B-Cell LymphomaSintilimabTP53 Mutation
Chinese Academy of Medical Sciences 30
Testing effectiveness (Phase 2)Looking for participantsNCT06366347
What this trial is testing

ALPINE: Maintenance Letrozole/Abemaciclib

Who this might be right for
Endometrial CancerRecurrent Endometrial CancerTP53
Dana-Farber Cancer Institute 32
Early research (Phase 1)Active Not RecruitingNCT05396859
What this trial is testing

Entrectinib in Combination With ASTX727 for the Treatment of Relapsed/Refractory TP53 Mutated Acute Myeloid Leukemia

Who this might be right for
Acute Myeloid LeukemiaRecurrent Acute Myeloid LeukemiaRefractory Acute Myeloid Leukemia
OHSU Knight Cancer Institute 13
Early research (Phase 1)Study completedNCT02143635
What this trial is testing

Study to Determine and Evaluate a Safe and Tolerated Dose of HDM201 in Patients With Selected Advanced Tumors That Are TP53wt

Who this might be right for
Advanced Solid and Hematological TP53wt Tumors
Novartis Pharmaceuticals 208
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07449286
What this trial is testing

IFN-α in Relapse Prevention.

Who this might be right for
Acute Myeloid LeukemiaMyelodysplastic Syndromes
Peking University People's Hospital 100
Large-scale testing (Phase 3)Active Not RecruitingNCT05624554
What this trial is testing

Nemtabrutinib vs Chemoimmunotherapy for Participants With Previously Untreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) Without TP53 Aberrations (MK-1026-008, BELLWAVE-008)

Who this might be right for
Chronic Lymphocytic LeukemiaSmall Lymphocytic Lymphoma
Merck Sharp & Dohme LLC 300
Testing effectiveness (Phase 2)Ended earlyNCT02688907
What this trial is testing

Phase II, Single-arm Study of AZD1775 Monotherapy in Relapsed Small Cell Lung Cancer Patients With MYC Family Amplification or CDKN2A Mutation Combined With TP53 Mutation

Who this might be right for
Small Cell Lung Cancer
Samsung Medical Center 7
Not applicableLooking for participantsNCT06369181
What this trial is testing

Neuroendocrine Transformation in RB1/TP53 Inactivated NSCLC

Who this might be right for
Neuroendocrine CarcinomaNon-small Cell Lung CancerHistology Transformation
Fudan University 50
Large-scale testing (Phase 3)WithdrawnNCT03377725
What this trial is testing

Decitabine and Arsenic Trioxide for Myelodysplastic Syndrome(MDS)

Who this might be right for
Myelodysplastic SyndromesP53 Mutation
Li Junmin
Testing effectiveness (Phase 2)WithdrawnNCT06690281
What this trial is testing

A Phase II Study of Adjuvant Immunotherapy Targeting KRAS G12D, KRAS G12V, or TP53 R175H for Participants With Advanced Gastrointestinal Malignancies

Who this might be right for
Gastrointestinal CarcinomaPancreatic CancerHepatocellular Cancer+5 more
National Cancer Institute (NCI)
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