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Results for “TP53-mutated MDS and AML”

10 trials

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Showing 10 of 10 results

Testing effectiveness (Phase 2)Looking for participantsNCT05735717
What this trial is testing

MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies

Who this might be right for
Hematologic MalignancyAcute LeukemiaRemission+21 more
Masonic Cancer Center, University of Minnesota 70
Early research (Phase 1)Looking for participantsNCT05877599
What this trial is testing

NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

Who this might be right for
Non-small Cell Lung CancerHead and Neck Squamous Cell CarcinomaColorectal Carcinoma+5 more
AstraZeneca 45
Testing effectiveness (Phase 2)Looking for participantsNCT06778187
What this trial is testing

Oral-ATO for TP53-mutated Myeloid Malignancies

Who this might be right for
Acute Myeloid LeukemiaMyelodysplastic NeoplasmChronic Myelomonocytic Leukemia+2 more
The University of Hong Kong 30
Early research (Phase 1)Active Not RecruitingNCT07094464
What this trial is testing

Maintenance Therapy With Selinexor and Azacitidine in TP53 Mutant AML/MDS After Transplantation

Who this might be right for
TP53-mutated MDS and AMLAllogeneic Hematopoietic Stem Cell Transplantation
Daihong Liu 20
Testing effectiveness (Phase 2)Study completedNCT03931291
What this trial is testing

APR-246 in Combination With Azacitidine for TP53 Mutated AML (Acute Myeloid Leukemia) or MDS (Myelodysplastic Syndromes) Following Allogeneic Stem Cell Transplant

Who this might be right for
Acute Myeloid Leukemia or Myelodysplastic Syndromes
Aprea Therapeutics 33
Testing effectiveness (Phase 2)Study completedNCT03588078
What this trial is testing

Study of the Safety and Efficacy of APR-246 in Combination With Azacitidine

Who this might be right for
Myelodysplastic Syndrome With Gene MutationAcute Myeloid Leukemia With Gene MutationsMyeloproliferative Neoplasm+1 more
Groupe Francophone des Myelodysplasies 53
Testing effectiveness (Phase 2)UnknownNCT04906031
What this trial is testing

Sodium Stibogluconate in the MDS/AML With One of the 65 Defined p53 Mutations

Who this might be right for
Myelodysplastic SyndromesAcute Myeloid LeukemiaMyeloid Malignancy+3 more
First Affiliated Hospital of Jinan University 5
Very early researchEnded earlyNCT03272633
What this trial is testing

Irradiated Donor Cells Following Stem Cell Transplant in Controlling Cancer in Patients With Hematologic Malignancies

Who this might be right for
Acute Lymphoblastic LeukemiaAcute Myeloid Leukemia in RemissionHematopoietic Cell Transplantation Recipient+16 more
Rutgers, The State University of New Jersey 2
Early research (Phase 1)Not Yet RecruitingNCT07617363
What this trial is testing

ATRN-119 in Combination With Decitabine in Patients With TP53-Mutated AML or Higher-Risk MDS

Who this might be right for
Acute Myeloid LeukemiaHigh-risk Myelodysplastic Syndrome
Washington University School of Medicine 27
Early research (Phase 1)UnknownNCT03855371
What this trial is testing

Mutant p53-based Personalized Trial Using Decitabine and Arsenic Trioxide on AML/MDS

Who this might be right for
P53 MutationMyeloid MalignancyMDS+1 more
Ruijin Hospital 5