Not applicableLooking for participantsNCT05776212What this trial is testingQuantitative-imaging in Cardiac Transthyretin AmyloidosisWho this might be right forATTR-CM University of Edinburgh 140
Large-scale testing (Phase 3)Active Not RecruitingNCT04988386What this trial is testingOpen-Label Safety Study of Acoramidis (AG10) in Symptomatic ATTR ParticipantsWho this might be right forAmyloid Cardiomyopathy, Transthyretin-Related Eidos Therapeutics, a BridgeBio company 389
Post-approval studies (Phase 4)Study completedNCT04814186What this trial is testingAssess the Safety and Efficacy Of Tafamidis In Chinese Participants With Transthyretin Amyloid Cardiomyopathy (ATTR-CM)Who this might be right forTransthyretin Amyloid Cardiomyopathy Pfizer 53
Not applicableLooking for participantsNCT07791160What this trial is testingStudy of Acoramidis in Patients With Transthyretin Amyloid CardiomyopathyWho this might be right forTransthyretin Amyloid Cardiomyopathy (ATTR-CM) Bayer 500
Not applicableEnded earlyNCT04424914What this trial is testingGlobal Prevalence of ATTR-CM in Participants With HFpEFWho this might be right forTransthyretin Amyloid CardiomyopathyHeart Failure With Preserved Ejection Fraction Pfizer 347
Large-scale testing (Phase 3)Looking for participantsNCT06128629What this trial is testingMAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)Who this might be right forTransthyretin Amyloidosis (ATTR) With Cardiomyopathy Intellia Therapeutics 1,200
Not applicableNot Yet RecruitingNCT07784712What this trial is testingRight Ventricular Septal Biopsy to Detect Cardiac AmyloidosisWho this might be right forATTR-CM (Transthyretin Amyloid Cardiomyopathy)Heart Failure Geisinger Clinic 70
Large-scale testing (Phase 3)Study completedNCT04136171What this trial is testingCARDIO-TTRansform: A Study to Evaluate the Efficacy and Safety of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Participants With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)Who this might be right forTransthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM) Ionis Pharmaceuticals, Inc. 1,438
Not applicableLooking for participantsNCT07358078What this trial is testingDemonsTTRate: A Global, Observational, Multicenter, Long-term Study of Patients With ATTR-CM in a Real-World SettingWho this might be right forTransthyretin Amyloidosis With Cardiomyopathy Alnylam Pharmaceuticals 2,000
Large-scale testing (Phase 3)Study completedNCT04622046What this trial is testingALXN2060 in Japanese Participants With Symptomatic ATTR-CMWho this might be right forSymptomatic Transthyretin Amyloid Cardiomyopathy Alexion Pharmaceuticals, Inc. 25
Not applicableUnknownNCT05210010What this trial is testingA Prospective Study to Assess the Utility of CA-4F in a Canadian Cardiology SettingWho this might be right forTransthyretin Amyloid Cardiomyopathy ("ATTR-CM") Ensho Health Intelligent Systems Inc. 8
Large-scale testing (Phase 3)Enrolling By InvitationNCT05667493What this trial is testingAn Extension Study to Assess Long-Term Safety of Eplontersen in Adults With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)Who this might be right forTransthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM) Ionis Pharmaceuticals, Inc. 1,400
Not applicableLooking for participantsNCT07215715What this trial is testingUS Benchmarking Clinical StudyWho this might be right forHFpEF - Heart Failure With Preserved Ejection FractionHFmrEFATTR-CM (Transthyretin Amyloid Cardiomyopathy)+2 more eMyosound SAS 150
Post-approval studies (Phase 4)Looking for participantsNCT07306949What this trial is testingReal-Life Clinical Efficacy of Acoramidis in Participants With ATTR-CM and Association With Cardiac BiomarkersWho this might be right forTransthyretin-type Cardiac Amyloidosis Alexion Pharmaceuticals, Inc. 200