Early research (Phase 1)Study completedNCT05374564What this trial is testingParametric Cardiac 18F-flutemetamol PET Imaging in ATTR CardiomyopathyWho this might be right forCardiomyopathies, Primary Yale University 12
Not applicableUnknownNCT05375279What this trial is testingA PILOT Study on LSGB vs EMB in the Diagnosis of Cardiac Transthyretin AmyloidosisWho this might be right forAmyloidosis Unity Health Toronto 20
Large-scale testing (Phase 3)Study completedNCT02319005What this trial is testingENDEAVOUR: Phase 3 Multicenter Study of Revusiran (ALN-TTRSC) in Patients With Transthyretin (TTR) Mediated Familial Amyloidotic Cardiomyopathy (FAC)Who this might be right forTransthyretin (TTR) Mediated Familial Amyloidotic Cardiomyopathy (FAC)Amyloidosis, HereditaryAmyloid Neuropathies, Familial+3 more Alnylam Pharmaceuticals 206
Not applicableLooking for participantsNCT06034405What this trial is testingAnalysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac AmyloidosisWho this might be right forLumbar Spinal StenosisCardiac AmyloidosisATTR Amyloidosis Wild Type+3 more Columbia University 1,663
Not applicableWithdrawnNCT04363294What this trial is testingTargeted Testing for ATTR Among Aortic Stenosis Patients-PilotWho this might be right forAortic Valve StenosisCardiac Amyloidosis University of Texas Southwestern Medical Center
Not applicableLooking for participantsNCT06836011What this trial is testingStudy on Atrioventricular Regurgitation in Transthyretin Amyloid Cardiomyopathy: Definition, Prevalence, and Prognostic Impact.Who this might be right forATTR Amyloidosis With CardiomyopathyATTR-CMATTR Amyloidosis Wild Type+2 more Medical University of Vienna 600
Not applicableStudy completedNCT05139680What this trial is testingExamine the Clinical Effectiveness of Tafamidis in Patients With Mixed Phenotype Hereditary Transthyretin AmyloidosisWho this might be right forHereditary Transthyretin Amyloidosis (ATTRv) Cardiomyopathy (CM), Mixed Phenotype Pfizer 10
Very early researchStudy completedNCT04899180What this trial is testingPrevalence of Transthyretin Cardiac Amyloidosis in Clinically Significant Aortic StenosisWho this might be right forAortic StenosisTransthyretin AmyloidosisTransthyretin Amyloid Cardiomyopathy+1 more Mayo Clinic 4
Not applicableStudy completedNCT01623245What this trial is testingPrevalence of Transthyretin Amyloidosis in Hypertrophic CardiomyopathyWho this might be right forCardiac AmyloidosisAmyloidosis in Transthyretin (TTR)Hypertrophic Cardiomyopathy (HCM) Thibaud Damy 294
Testing effectiveness (Phase 2)Study completedNCT02292186What this trial is testingA Extension Study to Evaluate Revusiran (ALN-TTRSC) in Patients With Transthyretin (TTR) Cardiac AmyloidosisWho this might be right forTTR-mediated Amyloidosis Alnylam Pharmaceuticals 25
Post-approval studies (Phase 4)Study completedNCT05019027What this trial is testingN-of-1 for Beta-Blockers in Cardiac AmyloidosisWho this might be right forCardiac AmyloidosisHeart DiseasesTTR Cardiac Amyloidosis Weill Medical College of Cornell University 14
Large-scale testing (Phase 3)Study completedNCT04136171What this trial is testingCARDIO-TTRansform: A Study to Evaluate the Efficacy and Safety of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Participants With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)Who this might be right forTransthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM) Ionis Pharmaceuticals, Inc. 1,438
Not applicableUnknownNCT04985734What this trial is testingTransthyretin Amyloidosis Cardiomyopathy (ATTR-CM) in Patients With Idiopathic Peripheral NeuropathyWho this might be right forAmyloidosis CardiacAmyloid PolyneuropathyAmyloidosis+3 more University Hospital, Antwerp 200
Not applicableNo Longer AvailableNCT05505838What this trial is testingExpanded Access Protocol to Provide Patisiran to Patients With Transthyretin-mediated Amyloidosis With CardiomyopathyWho this might be right forTransthyretin-mediated Amyloidosis With CardiomyopathyATTR Amyloidosis With Cardiomyopathy Alnylam Pharmaceuticals
Not applicableActive Not RecruitingNCT06651073What this trial is testingATTR-CM: A Multi-country, Non-interventional Disease RegistryWho this might be right forTransthyretin Amyloid Cardiopathy Pfizer 350
Post-approval studies (Phase 4)Study completedNCT05633563What this trial is testingThe Effect of Trimetazidine on Mitochondrial Function, Myocardial Performance, and Invasive Hemodynamics in Patients Diagnosed With Wild-Type Transthyretin Cardiac AmyloidosisWho this might be right forTransthyretin Amyloid CardiopathyMitochondrial Pathology Steen Hvitfeldt Poulsen 24
Testing effectiveness (Phase 2)Study completedNCT02016365What this trial is testingSafety and Efficacy Study of Doxycycline/UrsoDeoxyCholicAcid on Disease Progression in ATTR AmyloidosisWho this might be right forTransthyretin AmyloidosisCardiomyopathy Umeå University 55
Not applicableStudy completedNCT03842163What this trial is testingPrevalence and Characteristics of Transthyretin Amyloidosis in Patients With Left Ventricular Hypertrophy of Unknown EtiologyWho this might be right forTransthyretin Amyloidosis Cardiomyopathy (ATTR-CM) Pfizer 812
Not applicableLooking for participantsNCT07215715What this trial is testingUS Benchmarking Clinical StudyWho this might be right forHFpEF - Heart Failure With Preserved Ejection FractionHFmrEFATTR-CM (Transthyretin Amyloid Cardiomyopathy)+2 more eMyosound SAS 150
Not applicableUnknownNCT04563286What this trial is testingPatient-Reported Outcome Measures in Wild-Type and Variant Cardiac Transthyretin AmyloidosisWho this might be right forTransthyretin Amyloidosis University of Messina 250