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Results for “Transthyretin-Related (ATTR) Familial Amyloid Cardiomyopathy”

35 trials

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Showing 20 of 35 results

Early research (Phase 1)Study completedNCT04601051
What this trial is testing

Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of NTLA-2001 in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy (ATTRv-PN) and Patients With Transthyretin Amyloidosis-Related Cardiomyopathy (ATTR-CM)

Who this might be right for
Transthyretin-Related (ATTR) Familial Amyloid PolyneuropathyTransthyretin-Related (ATTR) Familial Amyloid CardiomyopathyWild-Type Transthyretin Cardiac Amyloidosis
Intellia Therapeutics 72
Not applicableLooking for participantsNCT05697861
What this trial is testing

Long-Term Follow-Up (LTFU) of Subjects Dosed With NTLA-2001

Who this might be right for
Transthyretin-Related (ATTR) Familial Amyloid PolyneuropathyTransthyretin-Related (ATTR) Familial Amyloid CardiomyopathyWild-Type Transthyretin Cardiac Amyloidosis
Intellia Therapeutics 72
Large-scale testing (Phase 3)Study completedNCT03759379
What this trial is testing

HELIOS-A: A Study of Vutrisiran (ALN-TTRSC02) in Patients With Hereditary Transthyretin Amyloidosis (hATTR Amyloidosis)

Who this might be right for
Amyloidosis, HereditaryTransthyretin Amyloidosis
Alnylam Pharmaceuticals 164
Not applicableStudy completedNCT03812172
What this trial is testing

Screening for Cardiac Amyloidosis With Nuclear Imaging for Minority Populations

Who this might be right for
Amyloid Cardiomyopathy, Transthyretin-Related
Mathew S. Maurer, MD 646
Large-scale testing (Phase 3)Active Not RecruitingNCT06128629
What this trial is testing

MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)

Who this might be right for
Transthyretin Amyloidosis (ATTR) With Cardiomyopathy
Intellia Therapeutics 1,200
Not applicableActive Not RecruitingNCT05873868
What this trial is testing

Myocardial Effects in Patients With ATTRv With Polyneuropathy Treated With Patisiran or Vutrisiran

Who this might be right for
Transthyretin AmyloidosisAmyloidosis, Hereditary
Rennes University Hospital 20
Large-scale testing (Phase 3)Not Yet RecruitingNCT07116473
What this trial is testing

To Evaluate the Long-term Safety and Tolerability of Acoramidis in Participants With Newly Diagnosed ATTR-CM (ACT-EARLY OLE)

Who this might be right for
Amyloidosis in Transthyretin (TTR)Amyloidosis, FamilialAmyloid Cardiomyopathy+7 more
Eidos Therapeutics, a BridgeBio company 250
Large-scale testing (Phase 3)Active Not RecruitingNCT04153149
What this trial is testing

HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

Who this might be right for
Transthyretin Amyloidosis (ATTR) With Cardiomyopathy
Alnylam Pharmaceuticals 655
Large-scale testing (Phase 3)Study completedNCT03862807
What this trial is testing

Patisiran in Patients With Hereditary Transthyretin-mediated Amyloidosis (hATTR Amyloidosis) Disease Progression Post-Liver Transplant

Who this might be right for
Amyloidosis, FamilialTransthyretin Amyloidosis
Alnylam Pharmaceuticals 24
Early research (Phase 1)Study completedNCT03294707
What this trial is testing

Single and Multiple Ascending Dose Study Assessing the Safety, Tolerability, PK and PD of AG10

Who this might be right for
Amyloid Cardiomyopathy, Transthyretin-Related
Eidos Therapeutics, a BridgeBio company 56
Not applicableLooking for participantsNCT06261216
What this trial is testing

Association Between Lifetime Physical Activity and Exercise and the Development of Wild-type Transthyretin Amyloid Cardiomyopathy

Who this might be right for
Amyloid CardiomyopathyWild Type ATTR Amyloidosis
Medical University of Graz 189
Not applicableNot Yet RecruitingNCT06921408
What this trial is testing

Retrospective Identification of Scintigraphic Cardiac Amyloidosis (RISCA)

Who this might be right for
Cardiac AmyloidosisTransthyretin Amyloidosis
University Hospital, Lille 57
Not applicableNot Yet RecruitingNCT07238426
What this trial is testing

ATTRACT-52: Primary Care Cardiac Amyloidosis Screening in Ordu, Turkey

Who this might be right for
Cardiac AmyloidosisTransthyretin Amyloidosis
Kotyora Family Medicine Health Management and Education Association 800
Not applicableLooking for participantsNCT07196839
What this trial is testing

Determining the Association of TTR Stabilizing Therapy With Circulating TTR Amyloid Aggregates Over Time in Patients With ATTR-CM: Longitudinal Biomarker Study

Who this might be right for
Transthyretin (TTR) Amyloid Cardiomyopathy
University of Texas Southwestern Medical Center 50
Not applicableLooking for participantsNCT06465810
What this trial is testing

Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis

Who this might be right for
Transthyretin AmyloidosisATTR-CMATTRv-PN+3 more
AstraZeneca 1,850
Large-scale testing (Phase 3)Active Not RecruitingNCT06672237
What this trial is testing

NTLA-2001 in ATTRv-PN

Who this might be right for
Neuromuscular DiseaseNeuromuscular Diseases (NMD)Neurodegenerative Disease+17 more
Intellia Therapeutics 50
Not applicableActive Not RecruitingNCT05311488
What this trial is testing

Early Detection of Neuropathy in ATTRv

Who this might be right for
Hereditary Amyloidosis, Transthyretin-Related
University of Pennsylvania 47
Not applicableActive Not RecruitingNCT03431896
What this trial is testing

Monitoring of Early Disease Progression in Hereditary Transthyretin Amyloidosis

Who this might be right for
AmyloidosisAmyloidAmyloid Neuropathies, Familial+4 more
The Cleveland Clinic 30
Not applicableStudy completedNCT06365593
What this trial is testing

HATTR Polyneuropathy in Russia

Who this might be right for
Hereditary Transthyretin Amyloidosis
AstraZeneca 100
Not applicableStudy completedNCT03190577
What this trial is testing

Assessment of the Prevalence of TTR Amyloid Neuropathy in a Population of Patients With Neuropathy of Unknown Aetiology

Who this might be right for
Familial Amyloid NeuropathyTransthyretin Amyloidosis
Nantes University Hospital 400
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