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Results for “Trastuzumab Deruxtecan”

155 trials

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Showing 20 of 155 results

Post-approval studies (Phase 4)Looking for participantsNCT05376878
What this trial is testing

An Investigational Scan (64Cu-DOTA-Trastuzumab PET/MRI) in Imaging Patients With HER2+ Breast Cancer With Brain Metastasis

Who this might be right for
Anatomic Stage IV Breast Cancer AJCC v8Metastatic Breast CarcinomaMetastatic Malignant Neoplasm in the Brain
City of Hope Medical Center 10
Testing effectiveness (Phase 2)Study completedNCT07529613
What this trial is testing

Trastuzumab Deruxtecan Plus Nivolumab Plus Capecitabine Plus Oxaliplatin for HER2 Low Gastric and Gastroesophageal Junction Adenocarcinoma

Who this might be right for
Gastric AdenocarcinomaGastroesophageal Junction Adenocarcinoma
National Cancer Center Hospital East 30
Not applicableStudy completedNCT05458401
What this trial is testing

EUropean Real-world Experience Of Previously Treated Advanced/Metastatic HER2-positive Breast Cancer Patients Accessing Trastuzumab Deruxtecan

Who this might be right for
HER2-positive Breast Cancer
Daiichi Sankyo 256
Testing effectiveness (Phase 2)Active Not RecruitingNCT04538742
What this trial is testing

A Phase 1b/2 Study of T-DXd Combinations in HER2-positive Metastatic Breast Cancer

Who this might be right for
Metastatic Breast Cancer
AstraZeneca 245
Large-scale testing (Phase 3)Looking for participantsNCT06819007
What this trial is testing

Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01)

Who this might be right for
Ovarian Cancer
Daiichi Sankyo 582
Testing effectiveness (Phase 2)Active Not RecruitingNCT04639219
What this trial is testing

T-DXd for the Treatment of Solid Tumors Harboring HER2 Activating Mutations

Who this might be right for
Advanced Solid Tumors With HER2 Mutation,eg:Colorectal,Urothelial,Gastric, Hepatobiliary,Endometrial,Melanoma,Ovarian,Cervical,Salivary Gland,Pancreatic,Breast
AstraZeneca 102
Large-scale testing (Phase 3)Active Not RecruitingNCT04704934
What this trial is testing

Trastuzumab Deruxtecan for Subjects With HER2-Positive Gastric Cancer or Gastro-Esophageal Junction Adenocarcinoma After Progression on or After a Trastuzumab-Containing Regimen (DESTINY-Gastric04)

Who this might be right for
Gastric Cancer, AdenocarcinomaGastroesophageal Junction Adenocarcinoma
Daiichi Sankyo 490
Testing effectiveness (Phase 2)Looking for participantsNCT05965479
What this trial is testing

Developing ctDNA Guided Adjuvant Therapy for Gastrooesophageal Cancer

Who this might be right for
Gastrooesophageal Cancer
University of Southampton 25
Testing effectiveness (Phase 2)Looking for participantsNCT06610825
What this trial is testing

Castrate Resistant Prostate Cancer Enhertu Therapy

Who this might be right for
Prostate Cancer MetastaticProstate CancerCRPC
Washington D.C. Veterans Affairs Medical Center 60
Testing effectiveness (Phase 2)Looking for participantsNCT07012031
What this trial is testing

Sotorasib in Combination With Trastuzumab Deruxtecan for the Treatment of Locally Advanced and Metastatic Non-small Cell Lung Cancer With a KRAS G12C Mutation

Who this might be right for
Locally Advanced Lung Non-Small Cell CarcinomaMetastatic Lung Non-Small Cell CarcinomaStage III Lung Cancer AJCC v8+1 more
National Cancer Institute (NCI) 37
Not applicableNot Yet RecruitingNCT07465172
What this trial is testing

GDF-15 and Its Relationship With Treatment-related ADverse Events in Breast Cancer

Who this might be right for
Breast Cancer
Breast Cancer Trials, Australia and New Zealand 150
Large-scale testing (Phase 3)Looking for participantsNCT06899126
What this trial is testing

Study of Trastuzumab Deruxtecan, Pembrolizumab, and Platinum-based Chemotherapy in First-line HER2 Overexpressing Non-small Cell Lung Cancer

Who this might be right for
Non-small Cell Lung Cancer
Daiichi Sankyo 686
Testing effectiveness (Phase 2)Looking for participantsNCT07446452
What this trial is testing

Disitamab Vedotin Plus Bevacizumab in HER2-Low Metastatic Breast Cancer After T-DXd Failure: A Phase II Study

Who this might be right for
HER2-low Breast Cancer
The First Affiliated Hospital with Nanjing Medical University 37
Not applicableLooking for participantsNCT06928818
What this trial is testing

Trastuzumab Emtansine(T-DM1) After Trastuzumab Deruxtecan(T-DXd) in HER2-Positive Breast Cancer in Korea

Who this might be right for
Cancer of BreastTrastuzumab EmtansineTrastuzumab Deruxtecan
Seoul National University Hospital 100
Early research (Phase 1)Active Not RecruitingNCT05650879
What this trial is testing

ELVN-002 in HER2 Mutant Non-Small Cell Lung Cancer

Who this might be right for
HER2 Mutant Non-small Cell Lung CancerHER2-positive Metastatic Breast CancerHER2 Gene Mutation+1 more
Enliven Therapeutics 198
Not applicableLooking for participantsNCT06727227
What this trial is testing

Real-world Study of Trastuzumab Deruxtecan in Patients With Unresectable or Metastatic HER2-low Breast Cancer

Who this might be right for
Breast Cancer
AstraZeneca 138
Testing effectiveness (Phase 2)Looking for participantsNCT05900206
What this trial is testing

Trastuzumab Deruxtecan Versus Standard Neoadjuvant Treatment for HER2-positive Breast Cancer

Who this might be right for
Breast Cancer
Karolinska University Hospital 370
Not applicableActive Not RecruitingNCT06945224
What this trial is testing

A ReaL World Study of DS-8201

Who this might be right for
Breast Cancer MetastaticTreatment Efficacy
Fudan University 300
Testing effectiveness (Phase 2)Looking for participantsNCT05408845
What this trial is testing

Testing the Use of Ado-Trastuzumab Emtansine Compared to the Usual Treatment (Chemotherapy With Docetaxel Plus Trastuzumab) or Trastuzumab Deruxtecan for Recurrent, Metastatic, or Unresectable HER2-Expressing Salivary Gland Cancers

Who this might be right for
Metastatic Salivary Gland CarcinomaRecurrent Salivary Gland CarcinomaStage III Major Salivary Gland Cancer AJCC v8+2 more
NRG Oncology 146
Not applicableStudy completedNCT06833268
What this trial is testing

Real-world Outcomes of Patients With HER2+ Metastatic Breast Cancer After Treatment With Trastuzumab Deruxtecan

Who this might be right for
HER2-positive Breast Cancer
Daiichi Sankyo 228
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