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Results for “Trop2”

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Showing 20 of 0 results

Testing effectiveness (Phase 2)Temporarily pausedNCT05922930
What this trial is testing

Study of TROP2 CAR Engineered IL15-transduced Cord Blood-derived NK Cells Delivered Intraperitoneally for the Management of Platinum Resistant Ovarian Cancer, Mesonephric-like Adenocarcinoma, and Pancreatic Cancer

Who this might be right for
Pancreatic CancerOvarian CancerAdenocarcinoma
M.D. Anderson Cancer Center 51
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06480136
What this trial is testing

SHR-A1921 Combined With Adebrelimab in the Treatment of Advanced NSCLC Who Failed the Previous Standard First-line Treatment

Who this might be right for
NSCLC
Shanghai Pulmonary Hospital, Shanghai, China 32
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07368543
What this trial is testing

Sequencing SG vs. T-DXd in HER2-Low/TROP2-High Metastatic Breast Cancer

Who this might be right for
Metastatic Breast Cancer
Fudan University 216
Large-scale testing (Phase 3)Looking for participantsNCT07291037
What this trial is testing

Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations

Who this might be right for
Non-small Cell Lung Cancer (NSCLC)
AstraZeneca 400
Early research (Phase 1)Active Not RecruitingNCT05174637
What this trial is testing

FDA018-ADC in Patients With Advanced Solid Tumors

Who this might be right for
Advanced/ Metastatic Solid Tumors
Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. 78
Testing effectiveness (Phase 2)Looking for participantsNCT05489211
What this trial is testing

Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)

Who this might be right for
Endometrial CancerGastric CancerMetastatic Castration-resistant Prostate Cancer+4 more
AstraZeneca 454
Testing effectiveness (Phase 2)Looking for participantsNCT07411599
What this trial is testing

Dual Administration Of Intraperitoneal And Intravenous TROP2-Directed CAR-NK With TGF-Beta Receptor 2 (TGFBR2) Knock Out (KO) Therapy For Colorectal Cancer-Related Peritoneal Carcinomatosis: A Phase 1/2 Trial ("Chip-CRC Trial")

Who this might be right for
Colorectal CancerPeritoneal MetastasesCarcinomatosis
M.D. Anderson Cancer Center 28
Large-scale testing (Phase 3)Looking for participantsNCT07216703
What this trial is testing

A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)

Who this might be right for
Cervical Cancer
Merck Sharp & Dohme LLC 1,023
Large-scale testing (Phase 3)Looking for participantsNCT06851663
What this trial is testing

Trop2-targeted immunoPET Imaging of Solid Tumors

Who this might be right for
Solid TumorSolid CarcinomaUroepithelial Carcinoma+11 more
RenJi Hospital 400
Testing effectiveness (Phase 2)Active Not RecruitingNCT04152499
What this trial is testing

Phase I-II, FIH, TROP2 ADC, Advanced Unresectable/Metastatic Solid Tumors, Refractory to Standard Therapies (KL264-01)

Who this might be right for
Epithelial Ovarian CancerGastric AdenocarcinomaGastroesophageal Junction Adenocarcinoma+7 more
Klus Pharma Inc. 1,410
Large-scale testing (Phase 3)Active Not RecruitingNCT05629585
What this trial is testing

Dato-DXd With or Without Durvalumab Versus Investigator's Choice of Therapy in Patients With Stage I-III Triple-negative Breast Cancer Without Pathological Complete Response Following Neoadjuvant Therapy (TROPION-Breast03)

Who this might be right for
Breast Cancer
AstraZeneca 1,174
Not applicableLooking for participantsNCT06715839
What this trial is testing

Target-specific immunoPET Imaging of Digestive System Carcinoma

Who this might be right for
MalignancyDigestive CancerDigestive System Neoplasm+12 more
RenJi Hospital 400
Testing effectiveness (Phase 2)Looking for participantsNCT07548060
What this trial is testing

A Phase II Study of Sacituzumab Tirumotecan in Combination With Furmonertinib in Patients With Non-squamous Non-Small Cell Lung Cancer Who Have Progressed After EGFR-TKI and Platinum-Based Chemotherapy

Who this might be right for
NSCLC Stage IVEGFR Gene Mutation
Tianjin Medical University Cancer Institute and Hospital 25
Early research (Phase 1)Looking for participantsNCT06066424
What this trial is testing

Phase 1 Dose Escalation and Expansion Study of TROP2 CAR Engineered IL15-transduced Cord Blood-derived NK Cells in Patients With Advanced Solid Tumors (TROPIKANA)

Who this might be right for
Solid Tumors
M.D. Anderson Cancer Center 54
Early research (Phase 1)Not Yet RecruitingNCT07797907
What this trial is testing

This Clinical Study is to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD), and Preliminary Antitumor Activity of BD200 in Participants With Advanced or Metastatic Cancer.

Who this might be right for
Solid Tumor (Phase I)
Biolojic Design Ltd. 110
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07686588
What this trial is testing

Sacituzumab Tirumotecan Plus Immunotherapy for Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

Who this might be right for
Recurrent or Metastatic Head and Neck Carcinoma
Biying Chen 20
Early research (Phase 1)Not Yet RecruitingNCT07553390
What this trial is testing

Phase 1b Study Of TRICK-NK In Combination With T-Dxd In Treatment-Refractory Breast Cancers

Who this might be right for
Breast Cancer
M.D. Anderson Cancer Center 60
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07501169
What this trial is testing

Sacituzumab Tirumotecan in Combination With Anlotinib in Previously Treated Patients With Extensive-Stage Small Cell Lung Cancer (ES-SCLC)

Who this might be right for
Extensive-stage Small Cell Lung Cancer (ES-SCLC)
Sichuan University 33
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07729033
What this trial is testing

A Phase II Exploratory Study of Sacituzumab Tirumotecan Combined With Envafolimab for TROP2-Positive Advanced Biliary Tract Cancers Previously Treated With First-Line Immunotherapy Combined With Chemotherapy.

Who this might be right for
Advanced Biliary Tract Cancers
Tianjin Medical University Cancer Institute and Hospital 28
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07701122
What this trial is testing

Sacituzumab Tirumotecan in Previously Treated TROP2-Positive Advanced Biliary Tract Cancer

Who this might be right for
Advanced Biliary Tract Cancer(BTC)
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology 33
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