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Results for “Tuberous Sclerosis 1”

23 trials

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Showing 20 of 23 results

Not applicableEnrolling By InvitationNCT03655223
What this trial is testing

Early Check: Expanded Screening in Newborns

Who this might be right for
Spinal Muscular AtrophyFragile X SyndromeFragile X - Premutation+182 more
RTI International 30,000
Not applicableLooking for participantsNCT03050268
What this trial is testing

Familial Investigations of Childhood Cancer Predisposition

Who this might be right for
Acute LeukemiaAdenomatous PolyposisAdrenocortical Carcinoma+43 more
St. Jude Children's Research Hospital 1,500
Not applicableLooking for participantsNCT06065852
What this trial is testing

National Registry of Rare Kidney Diseases

Who this might be right for
Adenine Phosphoribosyltransferase DeficiencyAH AmyloidosisAHL Amyloidosis+81 more
UK Kidney Association 35,000
Early research (Phase 1)Study completedNCT06975605
What this trial is testing

Phase 1, Open-label, Drug-drug Interaction Study to Assess Effect Between Radiprodil and the Co-administered Drugs.

Who this might be right for
Tuberous Sclerosis Complex (TSC)Focal Cortical DysplasiaOther Neurological Disorders
GRIN Therapeutics, Inc. 18
Not applicableUnknownNCT02436746
What this trial is testing

The Cognitive Variability in NF1 and TSC Monozygotic Twins

Who this might be right for
Neurofibromatosis Type ITuberous Sclerosis Complex
Erasmus Medical Center 116
Testing effectiveness (Phase 2)Active Not RecruitingNCT06390865
What this trial is testing

Testing MLN0128 (TAK-228) as Potentially Targeted Treatment in Cancers With TSC1 or TSC2 Genetic Changes (MATCH - Subprotocol M)

Who this might be right for
Advanced LymphomaAdvanced Malignant Solid NeoplasmRefractory Lymphoma+2 more
National Cancer Institute (NCI) 49
Not applicableLooking for participantsNCT06523582
What this trial is testing

Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients

Who this might be right for
Neuroendocrine NeoplasmNeuroendocrine Neoplasm of Gastrointestinal TractNeuroendocrine Neoplasm of Lung+23 more
Universidad Nacional Autonoma de Mexico 750
Early research (Phase 1)Ended earlyNCT06965881
What this trial is testing

Study to Evaluate the Pharmacokinetics and Safety Effects Following Coadministration of Carbamazepine or Itraconazole With Radiprodil in Healthy Adults

Who this might be right for
Tuberous Sclerosis Complex (TSC)Focal Cortical DysplasiaOther Neurological Disorders
GRIN Therapeutics, Inc. 30
Early research (Phase 1)Looking for participantsNCT06308419
What this trial is testing

A Phase I Trial of Combination Gemcitabine and Nab-Sirolimus in Advanced Leiomyosarcomas or Advanced Soft-Tissue Sarcomas With TSC2 or TSC1 Loss-of-function Mutations or Deletions

Who this might be right for
LeiomyosarcomaSoft-tissue Sarcomas
M.D. Anderson Cancer Center 18
Early research (Phase 1)Study completedNCT01470209
What this trial is testing

A Phase I Study of BKM120 and Everolimus in Advanced Solid Malignancies

Who this might be right for
Solid TumorsLung Cancer
Emory University 43
Early research (Phase 1)Study completedNCT04774952
What this trial is testing

Dose Escalation of RMC-5552 Monotherapy in Relapsed/Refractory Solid Tumors

Who this might be right for
Solid Tumors
Revolution Medicines, Inc. 58
Not applicableLooking for participantsNCT00001532
What this trial is testing

Role of Genetic Factors in the Development of Lung Disease

Who this might be right for
Cystic FibrosisPulmonary FibrosisTuberous Sclerosis+2 more
National Heart, Lung, and Blood Institute (NHLBI) 3,500
Testing effectiveness (Phase 2)Active Not RecruitingNCT03047213
What this trial is testing

Sapanisertib in Treating Patients With Locally Advanced or Metastatic Bladder Cancer With TSC1 and/or TSC2 Mutations

Who this might be right for
Locally Advanced Bladder Urothelial CarcinomaMetastatic Transitional Cell CarcinomaMetastatic Urothelial Carcinoma+3 more
National Cancer Institute (NCI) 17
Large-scale testing (Phase 3)Ended earlyNCT04485104
What this trial is testing

Assessment of Adjunctive Cannabidiol Oral Solution (GWP42003-P) in Children With Tuberous Sclerosis Complex (TSC), Dravet Syndrome (DS), or Lennox-Gastaut Syndrome (LGS) Who Experience Inadequately-controlled Seizures

Who this might be right for
Seizure in Participants With Tuberous Sclerosis ComplexSeizure in Participants With Dravet SyndromeSeizure in Participants With Lennox-Gastaut Syndrome
Jazz Pharmaceuticals 3
Early research (Phase 1)UnknownNCT05508620
What this trial is testing

Sirolimus for Injection (Albumin-bound) in Patients With Advanced Solid Tumors

Who this might be right for
Malignant Solid Tumors
CSPC ZhongQi Pharmaceutical Technology Co., Ltd. 270
Not applicableStudy completedNCT07327164
What this trial is testing

Precision Medicine for Neurocutaneous Syndromes in Western China

Who this might be right for
Neurocutaneous SyndromesNeurofibromatosis Type 1 (NF1)Tuberous Sclerosis Complex (TSC)+2 more
West China Hospital 1,200
Testing effectiveness (Phase 2)UnknownNCT05103358
What this trial is testing

Phase 2 Basket Trial of Nab-sirolimus in Patients With Malignant Solid Tumors With Pathogenic Alterations in TSC1/TSC2 Genes (PRECISION 1)

Who this might be right for
TumorTumor, SolidMetastasis+18 more
Aadi Bioscience, Inc. 120
Testing effectiveness (Phase 2)Study completedNCT02201212
What this trial is testing

Everolimus for Cancer With TSC1 or TSC2 Mutation

Who this might be right for
TSC1TSC2Tuberous Sclerosis Complex+1 more
Dana-Farber Cancer Institute 30
Testing effectiveness (Phase 2)Study completedNCT02352844
What this trial is testing

Everolimus in Patients With Advanced Solid Malignancies With TSC1, TSC2, NF1, NF2, or STK11 Mutations

Who this might be right for
Solid MalignancySolid Tumor
Washington University School of Medicine 12
Post-approval studies (Phase 4)Study completedNCT05864846
What this trial is testing

Investigate Behavioral and Other Co-Occurring Outcomes With Epidiolex as Add-On Therapy in Participants Aged 1 to 65 Years of Age With Tuberous Sclerosis Complex

Who this might be right for
Tuberous Sclerosis Complex Associated Neuropsychiatric Disease
Jazz Pharmaceuticals 79
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