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Results for “Tuberous Sclerosis 2”

25 trials

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Showing 20 of 25 results

Testing effectiveness (Phase 2)Not Yet RecruitingNCT07680322
What this trial is testing

The Safety and Efficacy of AV078 in Participants With Tuberous Sclerosis Complex (TSC) Refractory Epilepsy

Who this might be right for
Tuberous Sclerosis ComplexEpilepsy
Aeovian Pharmaceuticals, Inc. 42
Not applicableApproved For MarketingNCT03817515
What this trial is testing

Expanded Access for ABI-009 in Patients With Advanced PEComa and Patients With a Malignancy With Relevant Genetic Mutations or mTOR Pathway Activation

Who this might be right for
PEComa, MalignantTSC1TSC2+1 more
Aadi Bioscience, Inc.
Not applicableLooking for participantsNCT06065852
What this trial is testing

National Registry of Rare Kidney Diseases

Who this might be right for
Adenine Phosphoribosyltransferase DeficiencyAH AmyloidosisAHL Amyloidosis+81 more
UK Kidney Association 35,000
Testing effectiveness (Phase 2)Study completedNCT05626634
What this trial is testing

Open-label, Long-term Safety Study of LP352 in Subjects With Developmental and Epileptic Encephalopathy

Who this might be right for
Developmental and Epileptic EncephalopathyDravet SyndromeLennox-Gastaut Syndrome
Longboard Pharmaceuticals 41
Testing effectiveness (Phase 2)Active Not RecruitingNCT03047213
What this trial is testing

Sapanisertib in Treating Patients With Locally Advanced or Metastatic Bladder Cancer With TSC1 and/or TSC2 Mutations

Who this might be right for
Locally Advanced Bladder Urothelial CarcinomaMetastatic Transitional Cell CarcinomaMetastatic Urothelial Carcinoma+3 more
National Cancer Institute (NCI) 17
Large-scale testing (Phase 3)Study completedNCT00790400
What this trial is testing

Efficacy and Safety of RAD001 in Patients Aged 18 and Over With Angiomyolipoma Associated With Either Tuberous Sclerosis Complex (TSC) or Sporadic Lymphangioleiomyomatosis (LAM)

Who this might be right for
Tuberous Sclerosis Complex (TSC)Lymphangioleiomyomatosis (LAM)
Novartis Pharmaceuticals 118
Testing effectiveness (Phase 2)Study completedNCT01289912
What this trial is testing

Trial of RAD001 and Neurocognition in Tuberous Sclerosis Complex (TSC)

Who this might be right for
Tuberous Sclerosis Complex
Mustafa Sahin 52
Large-scale testing (Phase 3)Ended earlyNCT04485104
What this trial is testing

Assessment of Adjunctive Cannabidiol Oral Solution (GWP42003-P) in Children With Tuberous Sclerosis Complex (TSC), Dravet Syndrome (DS), or Lennox-Gastaut Syndrome (LGS) Who Experience Inadequately-controlled Seizures

Who this might be right for
Seizure in Participants With Tuberous Sclerosis ComplexSeizure in Participants With Dravet SyndromeSeizure in Participants With Lennox-Gastaut Syndrome
Jazz Pharmaceuticals 3
Testing effectiveness (Phase 2)Study completedNCT06322342
What this trial is testing

Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent

Who this might be right for
Central Nervous System (CNS) LesionsBrain MetastasesBrain Neoplasms+22 more
Reveal Pharmaceuticals Inc. 18
Testing effectiveness (Phase 2)Active Not RecruitingNCT05103358
What this trial is testing

Phase 2 Basket Trial of Nab-sirolimus in Patients With Malignant Solid Tumors With Pathogenic Alterations in TSC1/TSC2 Genes (PRECISION 1)

Who this might be right for
TumorTumor, SolidMetastasis+18 more
Aadi Bioscience, Inc. 120
Early research (Phase 1)Looking for participantsNCT06308419
What this trial is testing

A Phase I Trial of Combination Gemcitabine and Nab-Sirolimus in Advanced Leiomyosarcomas or Advanced Soft-Tissue Sarcomas With TSC2 or TSC1 Loss-of-function Mutations or Deletions

Who this might be right for
LeiomyosarcomaSoft-tissue Sarcomas
M.D. Anderson Cancer Center 18
Large-scale testing (Phase 3)Study completedNCT01713946
What this trial is testing

A Placebo-controlled Study of Efficacy & Safety of 2 Trough-ranges of Everolimus as Adjunctive Therapy in Patients With Tuberous Sclerosis Complex (TSC) & Refractory Partial-onset Seizures

Who this might be right for
Tuberous Sclerosis Complex-associated Refractory Seizures
Novartis Pharmaceuticals 366
Testing effectiveness (Phase 2)Study completedNCT04595513
What this trial is testing

Stopping TSC Onset and Progression 2: Epilepsy Prevention in TSC Infants

Who this might be right for
Tuberous Sclerosis ComplexEpilepsy
Children's Hospital Medical Center, Cincinnati 5
Not applicableActive Not RecruitingNCT03655223
What this trial is testing

Early Check: Expanded Screening in Newborns

Who this might be right for
Spinal Muscular AtrophyFragile X SyndromeFragile X - Premutation+182 more
RTI International 30,000
Testing effectiveness (Phase 2)Ended earlyNCT03363763
What this trial is testing

Topical Sirolimus Ointment for Cutaneous Angiofibromas in Subjects With Tuberous Sclerosis Complex

Who this might be right for
Angiofibroma of FaceTuberous Sclerosis
Aucta Pharmaceuticals, Inc 24
Large-scale testing (Phase 3)Study completedNCT03826628
What this trial is testing

Dose-Ranging Efficacy and Safety Study of Topical Rapamycin Cream for Facial Angiofibroma Associated With Tuberous Sclerosis Complex

Who this might be right for
Facial AngiofibromaTuberous Sclerosis
Dermatology Specialties Limited Partnership 107
Testing effectiveness (Phase 2)Study completedNCT02352844
What this trial is testing

Everolimus in Patients With Advanced Solid Malignancies With TSC1, TSC2, NF1, NF2, or STK11 Mutations

Who this might be right for
Solid MalignancySolid Tumor
Washington University School of Medicine 12
Early research (Phase 1)Ended earlyNCT06965881
What this trial is testing

Study to Evaluate the Pharmacokinetics and Safety Effects Following Coadministration of Carbamazepine or Itraconazole With Radiprodil in Healthy Adults

Who this might be right for
Tuberous Sclerosis Complex (TSC)Focal Cortical DysplasiaOther Neurological Disorders
GRIN Therapeutics, Inc. 30
Not applicableLooking for participantsNCT06523582
What this trial is testing

Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients

Who this might be right for
Neuroendocrine NeoplasmNeuroendocrine Neoplasm of Gastrointestinal TractNeuroendocrine Neoplasm of Lung+23 more
Universidad Nacional Autonoma de Mexico 750
Testing effectiveness (Phase 2)Active Not RecruitingNCT06390865
What this trial is testing

Testing MLN0128 (TAK-228) as Potentially Targeted Treatment in Cancers With TSC1 or TSC2 Genetic Changes (MATCH - Subprotocol M)

Who this might be right for
Advanced LymphomaAdvanced Malignant Solid NeoplasmRefractory Lymphoma+2 more
National Cancer Institute (NCI) 49
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