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Results for “Unresectable Locally Advanced or Metastatic Cancer”

674 trials

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Showing 20 of 674 results

Early research (Phase 1)Ended earlyNCT01525069
What this trial is testing

Hepatic Arterial Infusion in Treating Patients With Locally Advanced, Non-Metastatic Cholangiocarcinoma

Who this might be right for
CholangiocarcinomaLiver Neoplasms
Washington University School of Medicine 27
Very early researchActive Not RecruitingNCT04634227
What this trial is testing

Gemcitabine Plus Ascorbate for Sarcoma in Adults (Pilot)

Who this might be right for
SarcomaSoft Tissue SarcomaUnresectable Soft Tissue Sarcoma+2 more
University of Iowa 30
Testing effectiveness (Phase 2)UnknownNCT05522894
What this trial is testing

AK104 Alone or in Combination With Chemotherapy in the First-line Treatment of ESCC

Who this might be right for
Unresectable Esophageal Squamous Cell CarcinomaLocally Advanced Esophageal Squamous Cell CarcinomaMetastatic Esophageal Squamous Cell Carcinoma
Chinese Academy of Medical Sciences 80
Not applicableUnknownNCT03881501
What this trial is testing

Evaluate the Treatment With Sintilimab Injection Plus Endostar in Hepatocellular Carcinoma

Who this might be right for
Hepatocellular Carcinoma Non-resectable
Huazhong University of Science and Technology 2
Testing effectiveness (Phase 2)Looking for participantsNCT07102901
What this trial is testing

Safety and Efficacy of SHR2554 Combined With Other Antitumor Therapies in Gastric or Gastro-oesophageal Junction Adenocarcinoma

Who this might be right for
Advanced Gastric CancerMetastatic Gastric CancerGastroesophageal Junction Adenocarcinoma
Jiangsu HengRui Medicine Co., Ltd. 351
Testing effectiveness (Phase 2)Active Not RecruitingNCT06041802
What this trial is testing

Pembrolizumab (+) Berahyaluronidase Alfa (MK-3475A) (Pembrolizumab Formulated With Berahyaluronidase Alfa (MK-5180)) in Japanese Participants With Recurrent or Metastatic Cutaneous Squamous Cell Carcinoma (R/M cSCC) or Locally Advanced (LA) Unresectable cSCC (MK-3475A-E39)

Who this might be right for
Squamous Cell Carcinoma
Merck Sharp & Dohme LLC 19
Testing effectiveness (Phase 2)UnknownNCT05900219
What this trial is testing

Efficacy and Safety of HL-085 Combined With Vemurafenib in BRAF V600E Patients With Non-small Cell Lung Cancer: a Phase II Clinical Study

Who this might be right for
Non-small-cell Lung Cancer
Shanghai Kechow Pharma, Inc. 75
Large-scale testing (Phase 3)Looking for participantsNCT07060807
What this trial is testing

A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)

Who this might be right for
Breast Neoplasms
Merck Sharp & Dohme LLC 1,000
Testing effectiveness (Phase 2)Ended earlyNCT05091528
What this trial is testing

A Safety and Activity Study of SBT6050 in Combination With Other HER2-directed Therapies for HER2-positive Cancers

Who this might be right for
HER2-positive Breast CancerHER2-positive Gastric CancerHER2-positive Colorectal Cancer+1 more
Silverback Therapeutics 2
Testing effectiveness (Phase 2)Looking for participantsNCT07480928
What this trial is testing

Dual-Targeting CAR-NK Cells Targeting Mesothelin (MSLN) and MUC1 in Advanced Pancreatic Ductal Adenocarcinoma

Who this might be right for
Pancreatic Ductal Adenocarcinoma (PDAC)Unresectable Locally Advanced or Metastatic Disease
Beijing Biotech 42
Testing effectiveness (Phase 2)Study completedNCT00389441
What this trial is testing

Study Of AG-013736 In Patients With 131I-Refractory Thyroid Cancer

Who this might be right for
Thyroid Neoplasms
Pfizer 52
Testing effectiveness (Phase 2)Looking for participantsNCT05592626
What this trial is testing

A Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors

Who this might be right for
Advanced Solid TumorsGenital Neoplasm, FemaleUrogenital Neoplasms+11 more
Marengo Therapeutics, Inc. 366
Large-scale testing (Phase 3)Looking for participantsNCT06997497
What this trial is testing

A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)

Who this might be right for
Colon AdenocarcinomaRectal Adenocarcinoma
Merck Sharp & Dohme LLC 477
Not applicableAvailableNCT06948955
What this trial is testing

Expanded Access to Bezuclastinib to be Coadministered With Sunitinib for Patients With Gastrointestinal Stromal Tumors

Who this might be right for
Gastrointestinal Neoplasms, Gastrointestinal Stromal Tumors
Cogent Biosciences, Inc.
Testing effectiveness (Phase 2)Study completedNCT03980925
What this trial is testing

Platinum-doublet Chemotherapy and Nivolumab for the Treatment of Subjects With Neuroendocrine Neoplasms (NENs) of the Gastroenteropancreatic (GEP) Tract or of Unknown (UK) Origin.

Who this might be right for
Neuroendocrine TumorsNeuroendocrine NeoplasmGastroenteropancreatic Neuroendocrine Tumor
Grupo Espanol de Tumores Neuroendocrinos 37
Not applicableUnknownNCT02184663
What this trial is testing

Evaluation of an Adapted Physical Activity Program in Patients With Unresectable Pancreatic Cancer

Who this might be right for
Unresectable Locally Advanced CancerMetastatic Pancreatic Cancer
GERCOR - Multidisciplinary Oncology Cooperative Group 313
Testing effectiveness (Phase 2)Looking for participantsNCT07105215
What this trial is testing

A I/II Phase Clinical Study to Evaluate the Safety and Efficacy of RC278 in the Treatment of Solid Tumors

Who this might be right for
Solid Tumors
RemeGen Co., Ltd. 312
Testing effectiveness (Phase 2)Study completedNCT00719550
What this trial is testing

AMG 102 Plus ECX for Unresectable Locally Advanced or Metastatic Gastric or Esophagogastric Junction Cancer

Who this might be right for
Esophagogastric Junction AdenocarcinomaGastric CancerEsophageal Cancer
Amgen 130
Testing effectiveness (Phase 2)Study completedNCT03359018
What this trial is testing

Apatinib Plus Anti-PD1 Therapy for Advanced Osteosarcoma

Who this might be right for
Progression-free SurvivalOverall SurvivalClinical Benefit Rate+1 more
Peking University People's Hospital 43
Testing effectiveness (Phase 2)Ended earlyNCT00085410
What this trial is testing

Bortezomib in Treating Patients With Unresectable Locally Advanced or Metastatic Adenocarcinoma of the Bile Duct or Gallbladder

Who this might be right for
Adenocarcinoma of the Extrahepatic Bile DuctAdenocarcinoma of the GallbladderAdvanced Adult Primary Liver Cancer+7 more
National Cancer Institute (NCI) 20
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