Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • About
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Unresectable Locally Advanced or Metastatic Disease”

627 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 627 results

Testing effectiveness (Phase 2)Study completedNCT01093222
What this trial is testing

Sorafenib Tosylate and Erlotinib Hydrochloride in Treating Patients With Locally Advanced, Unresectable, or Metastatic Gallbladder Cancer or Cholangiocarcinoma

Who this might be right for
Extrahepatic Bile Duct AdenocarcinomaGallbladder AdenocarcinomaGallbladder Adenocarcinoma With Squamous Metaplasia+6 more
National Cancer Institute (NCI) 40
Early research (Phase 1)Study completedNCT04641871
What this trial is testing

Sym021 in Combination With Either Sym022 or Sym023 or Sym023 and Irinotecan in Patients With Recurrent Advanced Selected Solid Tumor Malignancies

Who this might be right for
Metastatic CancerSolid Tumor
Symphogen A/S 78
Testing effectiveness (Phase 2)Active Not RecruitingNCT03225664
What this trial is testing

Trametinib and Pembrolizumab in Treating Patients With Recurrent Non-small Cell Lung Cancer That Is Metastatic, Unresectable, or Locally Advanced

Who this might be right for
Metastatic Lung Non-Small Cell CarcinomaRecurrent Lung Non-Small Cell CarcinomaStage III Lung Cancer AJCC v8+7 more
M.D. Anderson Cancer Center 37
Post-approval studies (Phase 4)Not Yet RecruitingNCT07502027
What this trial is testing

A Clinical Study of Iparomlimab and Tuvonralimab Combined With SOX Following Heterogeneous Radiotherapy as First-line Treatment for Unresectable Locally Advanced or Metastatic HER2-negative Gastric or Gastroesophageal Junction Adenocarcinoma

Who this might be right for
Gastric Cancer (Diagnosis)Gastric Cancer (GC)Gastroesophageal Junction Adenocarcinoma
Huazhong University of Science and Technology 55
Early research (Phase 1)Looking for participantsNCT07300241
What this trial is testing

Open-Label Phase 1/2 Study of NEO-811 in Subjects With Locally Advanced or Metastatic Non-Resectable Clear Cell Renal Cell Carcinoma

Who this might be right for
Clear Cell Renal Cell CarcinomaRenal Cell CarcinomaRCC+6 more
Neomorph, Inc 30
Testing effectiveness (Phase 2)Study completedNCT00578071
What this trial is testing

Phase I/II Study of Panitumumab, Capecitabine and Oxaliplatin w EBRT for Esophageal Cancer

Who this might be right for
Cancer of the Esophagus
Brian Czito 29
Testing effectiveness (Phase 2)Study completedNCT02767557
What this trial is testing

Study of Nab-Paclitaxel and Gemcitabine With or Without Tocilizumab in Pancreatic Cancer Patients

Who this might be right for
Unresectable Pancreatic Carcinoma
Herlev Hospital 147
Large-scale testing (Phase 3)Active Not RecruitingNCT05840211
What this trial is testing

Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Patients With Hormone Receptor-positive/Human Epidermal Growth Factor Receptor 2 Negative (HR+/HER2-) Metastatic Breast Cancer Who Have Received Endocrine Therapy

Who this might be right for
Locally Advanced or Unresectable Metastatic Breast CancerStage IV Breast Cancer
Gilead Sciences 654
Testing effectiveness (Phase 2)Study completedNCT00301899
What this trial is testing

Trastuzumab and Pertuzumab in Treating Patients With Unresectable Locally Advanced or Metastatic Breast Cancer That Did Not Respond to Previous Trastuzumab

Who this might be right for
Breast Cancer
National Institutes of Health Clinical Center (CC) 37
Early research (Phase 1)Study completedNCT01005472
What this trial is testing

Temozolomide and Sunitinib Malate in Treating Patients With Stage III or Stage IV Malignant Melanoma

Who this might be right for
Metastatic Melanoma
Jonsson Comprehensive Cancer Center 16
Testing effectiveness (Phase 2)UnknownNCT04202484
What this trial is testing

Tripletrumab Combined With Oxaliplatin and Teggio (SOX) in First-line Treatment of Gastric and Gastroesophageal Junction Adenocarcinoma

Who this might be right for
Gastric Cancer
RenJi Hospital 20
Large-scale testing (Phase 3)Active Not RecruitingNCT06343948
What this trial is testing

A Study Comparing BL-B01D1 With Chemotherapy of Physician's Choice in Patients With Unresectable Locally Advanced, Recurrent, or Metastatic HR+HER2- Breast Cancer(PANKU-Breast01)

Who this might be right for
HR+HER2- Breast Cancer
Sichuan Baili Pharmaceutical Co., Ltd. 383
Early research (Phase 1)WithdrawnNCT06626256
What this trial is testing

STIL101 for Injection for the Treatment of Locally Advanced, Metastatic or Unresectable Pancreatic Cancer, Colorectal Cancer, Renal Cell Cancer, Cervical Cancer and Melanoma

Who this might be right for
Locally Advanced Cervical CarcinomaLocally Advanced Colorectal CarcinomaLocally Advanced Malignant Solid Neoplasm+24 more
City of Hope Medical Center
Testing effectiveness (Phase 2)Study completedNCT01654692
What this trial is testing

A Combination of Ipilimumab and Fotemustine for Treat Unresectable Locally Advanced or Metastatic Melanoma

Who this might be right for
Metastatic Malignant Melanoma
Italian Network for Tumor Biotherapy 86
Early research (Phase 1)Looking for participantsNCT06963281
What this trial is testing

Study of IBI3020 Treatment in Participants With Late-Stage Solid Tumors

Who this might be right for
Solid Tumors
Innovent Biopharmaceutical Technology (Hangzhou) Co., LTD. 285
Early research (Phase 1)Looking for participantsNCT06440005
What this trial is testing

Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors

Who this might be right for
CancerAdvanced CancerLocally Advanced Carcinoma+8 more
Angiex, Inc. 80
Not applicableNot Yet RecruitingNCT07191405
What this trial is testing

Clinical Study of Chemotherapy and Immunotherapy Combined With Lactobacillus Johnsonii in Patients With Multiple Irresectable Solid Tumors

Who this might be right for
ImmunotherapyChemotherapy
Second Affiliated Hospital, School of Medicine, Zhejiang University 156
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06764368
What this trial is testing

Phase II Study of Adebrelimab, Chemotherapy, and Apatinib for Advanced Pulmonary Neuroendocrine Tumors

Who this might be right for
Neuroendocrine Tumors
Beijing Chest Hospital 39
Testing effectiveness (Phase 2)UnknownNCT04395989
What this trial is testing

An Umbrella Trial Based on Molecular Pathway for Patients With Metastatic TNBC.

Who this might be right for
TNBC - Triple-Negative Breast Cancer
Fudan University 139
Testing effectiveness (Phase 2)UnknownNCT04826107
What this trial is testing

Study of DP303c Injection in Patients With Advanced or Metastatic Gastric Cancer

Who this might be right for
Gastric Cancer
CSPC ZhongQi Pharmaceutical Technology Co., Ltd. 196
Load More Results