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Results for “VHL Gene Mutation”

13 trials

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Showing 13 of 13 results

Early research (Phase 1)Study completedNCT02108002
What this trial is testing

Effect of Vorinostat on Nervous System Hemangioblastomas in Von Hippel-Lindau Disease (Missense Mutation Only)

Who this might be right for
Von Hippel-Lindau Disease
National Institute of Neurological Disorders and Stroke (NINDS) 7
Testing effectiveness (Phase 2)Ended earlyNCT00001703
What this trial is testing

Vaccine Therapy With Tumor Specific Mutated VHL Peptides in Adult Cancer Patients With Renal Cell Carcinoma

Who this might be right for
Renal Cell Carcinoma
National Cancer Institute (NCI) 6
Testing effectiveness (Phase 2)Ended earlyNCT01712685
What this trial is testing

Imaging Studies of Kidney Cancer Using 18F-VM4-037

Who this might be right for
Carcinoma, Renal CellKidney Neoplasms
National Cancer Institute (NCI) 12
Early research (Phase 1)WithdrawnNCT03433833
What this trial is testing

Digoxin for Congenital Erythrocytosis Due to Up-Regulated Hypoxia Sensing

Who this might be right for
Polycythemia; FamilialErythrocytosis; FamilialVHL Gene Mutation+3 more
University of Illinois at Chicago
Testing effectiveness (Phase 2)Active Not RecruitingNCT03401788
What this trial is testing

Belzutifan (PT2977, MK-6482) for the Treatment of Von Hippel Lindau (VHL) Disease-Associated Renal Cell Carcinoma (RCC) (MK-6482-004)

Who this might be right for
VHL - Von Hippel-Lindau SyndromeVHL Gene MutationVHL Syndrome+3 more
Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) 50
Not applicableLooking for participantsNCT06194669
What this trial is testing

Mechanisms of Somatic Mutation and Tumor Initiation in Pre-malignant Kidney Tubule Cells

Who this might be right for
Carcinoma, Renal CellVon Hippel-Lindau Disease
IRCCS San Raffaele 50
Not applicableStudy completedNCT00075348
What this trial is testing

Genetic Study to Identify Gene Mutations in Participants Previously Enrolled in Clinical Trial NCI-99-C-0053 Who Have Von Hippel-Lindau Syndrome or Are at Risk for Von Hippel-Lindau Syndrome

Who this might be right for
Kidney CancerVon Hippel-lindau Syndrome
National Institutes of Health Clinical Center (CC) 260
Testing effectiveness (Phase 2)Study completedNCT01967576
What this trial is testing

Phase II Study of Axitinib (AG-013736) With Evaluation of the VEGF-pathway in Metastatic, Recurrent or Primary Unresectable Pheochromocytoma/Paraganglioma

Who this might be right for
PheochromocytomaParaganglioma
National Cancer Institute (NCI) 14
Not applicableLooking for participantsNCT03749980
What this trial is testing

MyVHL: Patient Natural History Study

Who this might be right for
Von Hippel-Lindau DiseaseHereditary Leiomyomatosis and Renal Cell CancerBirt-Hogg-Dube Syndrome+1 more
Joshua Mann, MPH 10,000
Testing effectiveness (Phase 2)Ended earlyNCT02315625
What this trial is testing

Study of Mutation-Targeted Therapy With Sunitinib or Everolimus in People With Advanced Low- or Intermediate-Grade Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas With or Without Cytoreductive Surgery

Who this might be right for
Neuroendocrine TumorsNeuroendocrine CarcinomaNeuroendocrine Neoplasms+2 more
National Cancer Institute (NCI) 16
Not applicableUnknownNCT02207686
What this trial is testing

Assessment of Residual VHL Function in Tumors - Can it Predict the Patients' Individual Course of Disease?

Who this might be right for
Von Hippel-Lindaus Disease
Marie Luise Bisgaard, MD 50
Not applicableUnknownNCT05534854
What this trial is testing

Frequency, Clinical Phenotype and Genetic Analysis of Heritable Kidney Cancer Syndromes

Who this might be right for
Renal Tumor HistologyKidney CancerRenal Cell Carcinoma+11 more
RenJi Hospital 500
Testing effectiveness (Phase 2)Study completedNCT03108066
What this trial is testing

MK-3795 (PT2385) for the Treatment of Von Hippel-Lindau Disease-Associated Clear Cell Renal Cell Carcinoma (MK-3795-003)

Who this might be right for
VHL Gene MutationVHLVHL Syndrome+8 more
Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) 4