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Results for “WHO Grade 1 Glioma”

21 trials

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Showing 20 of 21 results

Large-scale testing (Phase 3)Active Not RecruitingNCT04576117
What this trial is testing

Compare Treatment With the Drug Selumetinib Alone Versus Selumetinib and Vinblastine in Patients With Recurrent or Progressive Low-Grade Glioma

Who this might be right for
Recurrent Low Grade AstrocytomaRecurrent WHO Grade 2 GliomaRefractory Low Grade Astrocytoma+2 more
National Cancer Institute (NCI) 300
Early research (Phase 1)Study completedNCT03615404
What this trial is testing

Cytomegalovirus (CMV) RNA-Pulsed Dendritic Cells for Pediatric Patients and Young Adults With WHO Grade IV Glioma, Recurrent Malignant Glioma, or Recurrent Medulloblastoma

Who this might be right for
GlioblastomaMalignant GliomaMedulloblastoma Recurrent+3 more
Gary Archer Ph.D. 11
Testing effectiveness (Phase 2)Study completedNCT02330562
What this trial is testing

Stage 1: Marizomib + Bevacizumab in WHO Gr IV GBM; Stage 2: Marizomib Alone; Stage 3: Combination of Marizomib and Bevacizumab

Who this might be right for
Malignant GliomaGlioblastoma
Celgene 121
Early research (Phase 1)Active Not RecruitingNCT06410248
What this trial is testing

Triapine in Combination With Temozolomide for the Treatment of Patients With Recurrent Glioblastoma

Who this might be right for
Recurrent Glioblastoma, IDH-WildtypeRecurrent WHO Grade 2 GliomaRecurrent WHO Grade 3 Glioma+1 more
Northwestern University 30
Large-scale testing (Phase 3)Study completedNCT00369785
What this trial is testing

Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors

Who this might be right for
Brain TumorsMetastatic Disease
Wake Forest University Health Sciences 198
Early research (Phase 1)Study completedNCT02323880
What this trial is testing

Selinexor in Treating Younger Patients With Recurrent or Refractory Solid Tumors or High-Grade Gliomas

Who this might be right for
Malignant GliomaRecurrent Brain NeoplasmRecurrent Childhood Central Nervous System Neoplasm+7 more
Children's Oncology Group 59
Very early researchLooking for participantsNCT06333899
What this trial is testing

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

Who this might be right for
High Grade GliomaDiffuse Intrinsic Pontine GliomaAnaplastic Astrocytoma+6 more
Nationwide Children's Hospital 15
Early research (Phase 1)Ended earlyNCT00110032
What this trial is testing

Positron Emission Tomography Using Fluorine F 18 EF5 to Find Oxygen in Tumor Cells of Patients Who Are Undergoing Surgery or Biopsy for Newly Diagnosed Brain Tumors

Who this might be right for
Adult Anaplastic AstrocytomaAdult Anaplastic EpendymomaAdult Anaplastic Oligodendroglioma+24 more
National Cancer Institute (NCI) 46
Early research (Phase 1)Ended earlyNCT01989052
What this trial is testing

Ph 1/2 CTO With Lomustine for Bevacizumab-Naive Recurrent Glioma

Who this might be right for
Malignant Glioma (WHO Grade III or IV)
Annick Desjardins 9
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07389278
What this trial is testing

Combination ADI-PEG 20, TMZ, and RT for Treatment of Newly Diagnosed High-grade Glioma (HGG)

Who this might be right for
GlioblastomaHigh-Grade Glioma (WHO III-IV)High-grade Glioma+2 more
Sabine Mueller, MD, PhD 97
Testing effectiveness (Phase 2)Looking for participantsNCT05765812
What this trial is testing

Debio 0123 in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Debio 0123 in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma

Who this might be right for
Glioblastoma IDH (Isocitrate Dehydrogenase) WildtypeAstrocytoma, Grade III
Debiopharm International SA 116
Early research (Phase 1)Active Not RecruitingNCT04214392
What this trial is testing

Chimeric Antigen Receptor (CAR) T Cells With a Chlorotoxin Tumor-Targeting Domain for the Treatment of MMP2+ Recurrent or Progressive Glioblastoma

Who this might be right for
Recurrent GlioblastomaRecurrent Malignant GliomaRecurrent WHO Grade II Glioma+1 more
City of Hope Medical Center 19
Early research (Phase 1)Active Not RecruitingNCT03749187
What this trial is testing

BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas

Who this might be right for
GlioblastomaIDH1 Gene MutationIDH2 Gene Mutation+7 more
University of California, San Francisco 78
Large-scale testing (Phase 3)Looking for participantsNCT04166409
What this trial is testing

The Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma

Who this might be right for
Low Grade AstrocytomaLow Grade GliomaMetastatic Low Grade Astrocytoma+3 more
National Cancer Institute (NCI) 170
Testing effectiveness (Phase 2)Study completedNCT02590263
What this trial is testing

Study Evaluating ABT-414 in Japanese Subjects With Malignant Glioma

Who this might be right for
Malignant GliomaGlioblastoma Multiforme
AbbVie 53
Early research (Phase 1)Looking for participantsNCT04732065
What this trial is testing

ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors

Who this might be right for
Diffuse Midline Glioma (DMG)GlioblastomaRecurrent Ependymoma+5 more
Sabine Mueller, MD, PhD 208
Early research (Phase 1)Ended earlyNCT01954030
What this trial is testing

Phase 1/2 CTO + Bevacizumab for Recurrent Glioma Post-Bevacizumab Failure

Who this might be right for
Malignant Glioma (WHO Grade III or IV)
Annick Desjardins 17
Early research (Phase 1)Study completedNCT03434262
What this trial is testing

SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

Who this might be right for
Anaplastic AstrocytomaAnaplastic EpendymomaAnaplastic Ganglioglioma+53 more
St. Jude Children's Research Hospital 68
Early research (Phase 1)Ended earlyNCT04047303
What this trial is testing

CNS Penetration, PK and PD of Preoperative CC-90010 in Progressive/Recurrent Diffuse Astrocytoma, Anaplastic Astrocytoma and Glioblastoma

Who this might be right for
AstrocytomaGlioblastoma
Celgene 20
Not applicableStudy completedNCT00255671
What this trial is testing

Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders

Who this might be right for
Brain and Central Nervous System TumorsMetastatic CancerRadiation Toxicity
Case Comprehensive Cancer Center 76
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