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Results for “With Brain and/or Leptomeningeal Metastasis”

37 trials

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Showing 20 of 37 results

Testing effectiveness (Phase 2)Looking for participantsNCT07134153
What this trial is testing

Phase I/II Study of Intrathecal/Ommaya T-DXd in HER2-Expressing Breast Cancer With Leptomeningeal/Brain Metastases

Who this might be right for
Breast Cancer
Fudan University 139
Testing effectiveness (Phase 2)Study completedNCT00445965
What this trial is testing

Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer

Who this might be right for
Brain and Central Nervous System TumorsIntraocular MelanomaLung Cancer+7 more
Memorial Sloan Kettering Cancer Center 78
Early research (Phase 1)Ended earlyNCT00112619
What this trial is testing

Topotecan in Treating Young Patients With Neoplastic Meningitis Due to Leukemia, Lymphoma, or Solid Tumors

Who this might be right for
Brain and Central Nervous System TumorsCarcinoma of Unknown PrimaryLeukemia+2 more
Pediatric Brain Tumor Consortium 19
Testing effectiveness (Phase 2)Looking for participantsNCT06810804
What this trial is testing

A Phase IIa Study to Evaluate NBQ72S

Who this might be right for
Breast Cancer
Nantong Bencao Quadriga Medical Technology Co. Ltd. 10
Early research (Phase 1)Study completedNCT02423525
What this trial is testing

Safety Study of Afatinib for Brain Cancer

Who this might be right for
Brain Cancer
Santosh Kesari 24
Early research (Phase 1)Not Yet RecruitingNCT07674693
What this trial is testing

Phase 1 Study of WBRT or PCSI With REYOBIQ for Leptomeningeal Metastases

Who this might be right for
Leptomeningeal Metastases
NYU Langone Health 29
Not applicableUnknownNCT06410040
What this trial is testing

A Retrospective Study of the Efficacy and Safety of Lolatinib in ALK+ NSCLC Patients With Brain or Meningeal Metastasis

Who this might be right for
ALK-positive Non-small Cell Lung CancerBrain MetastasesMeningeal Metastasis
Sichuan Cancer Hospital and Research Institute 28
Early research (Phase 1)Active Not RecruitingNCT04661384
What this trial is testing

Brain Tumor-Specific Immune Cells (IL13Ralpha2-CAR T Cells) for the Treatment of Leptomeningeal Glioblastoma, Ependymoma, or Medulloblastoma

Who this might be right for
EpendymomaGlioblastomaMedulloblastoma+1 more
City of Hope Medical Center 10
Early research (Phase 1)Ended earlyNCT00512460
What this trial is testing

RTA 744 Injection in Patients With Leptomeningeal Disease

Who this might be right for
Neoplastic MeningitisSolid TumorLymphoma+2 more
M.D. Anderson Cancer Center 7
Testing effectiveness (Phase 2)Study completedNCT02336451
What this trial is testing

A Phase II Study to Evaluate the Efficacy and Safety of Oral Ceritinib in Patients With ALK-positive NSCLC Metastatic to the Brain and/or to Leptomeninges

Who this might be right for
ALK-positive Non-small Cell Lung Cancer
Novartis Pharmaceuticals 156
Early research (Phase 1)Study completedNCT02228369
What this trial is testing

Oral Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors, AZD3759 or AZD9291, in Patients Who Have Advanced Non-Small Cell Lung Cancer

Who this might be right for
EGFR Mutation Positive Advanced Non Small Cell Lung Cancer
AstraZeneca 108
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07751744
What this trial is testing

Phase 1/2 Study Evaluating the Safety, PK/PD, and Clinical Activity of Oral JBI-778 in Patients With Brain Metastases, Leptomeningeal Disease, or Recurrent High Grade Glioma

Who this might be right for
Brain Metastases From Solid TumorsLeptomeningeal DiseaseHigh Grade Glioma (HGG)+1 more
Jubilant Therapeutics Inc. 113
Not applicableActive Not RecruitingNCT05793489
What this trial is testing

Prospective Double Arm Randomized Trial: WBRT Alone and WBRT Plus Silibinin

Who this might be right for
Brain Metastases, Adult
Istituto Clinico Humanitas 44
Not applicableNot Yet RecruitingNCT07689721
What this trial is testing

CtDNA-Guided Intraventricular Therapy for CNS Malignancies

Who this might be right for
Leptomeningeal DiseaseGlioblastomaBrain Metastases+2 more
Alireza Mansouri 77
Testing effectiveness (Phase 2)Study completedNCT02616393
What this trial is testing

Phase 2 Study of Study of Tesevatinib in Subjects With NSCLC and Brain or Leptomeningeal Metastases

Who this might be right for
Non-Small Cell Lung CancerLeptomeningeal MetastasesBrain Metastases
Kadmon Corporation, LLC 36
Early research (Phase 1)Study completedNCT00031928
What this trial is testing

Mafosfamide in Treating Patients With Progressive or Refractory Meningeal Tumors

Who this might be right for
Brain and Central Nervous System Tumors
National Cancer Institute (NCI) 3,000
Testing effectiveness (Phase 2)Study completedNCT00992602
What this trial is testing

Liposomal Cytarabine and High-Dose Methotrexate in Treating Patients With Central Nervous System Metastases From Breast Cancer

Who this might be right for
Central Nervous System MetastasesLeptomeningeal MetastasesRecurrent Breast Cancer+2 more
University of Washington 3
Early research (Phase 1)WithdrawnNCT06137651
What this trial is testing

Trotabresib in Combination With Vinorelbine and Radiation Therapy for the Treatment of HER2+ Breast Cancer With Central Nervous System or Leptomeningeal Metastasis

Who this might be right for
Breast CarcinomaMetastatic Malignant Neoplasm in the BrainMetastatic Malignant Neoplasm in the Leptomeninges
Northwestern University
Early research (Phase 1)Study completedNCT00025311
What this trial is testing

Topotecan in Treating Patients With Recurrent, Progressive, or Refractory Cancer That is Metastatic to the Lining Around the Brain

Who this might be right for
Brain and Central Nervous System Tumors
NYU Langone Health
Not applicableUnknownNCT03029065
What this trial is testing

Detection of CSF Next Generation Sequencing in the Application of Brain Metastases From Lung Adenocarcinoma or Meningeal Metastasis

Who this might be right for
Recruitment
Shandong Cancer Hospital and Institute 50
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