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Results for “brca2 Gene Mutation”

181 trials

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Showing 20 of 181 results

Testing effectiveness (Phase 2)Ended earlyNCT04171700
What this trial is testing

Evaluate Rucaparib in Participants With Solid Tumors and With Deleterious Mutations in HRR Genes

Who this might be right for
Solid Tumor
pharmaand GmbH 83
Not applicableStudy completedNCT04425200
What this trial is testing

Prevalence of HRR-related Genes Mutations and Prognosis in Metastatic Castration Resistant Prostate Cancer (mCRPC) Patients in Real World Setting

Who this might be right for
Prostatic Neoplasms
AstraZeneca 205
Testing effectiveness (Phase 2)WithdrawnNCT00386399
What this trial is testing

Study of Mitomycin-C in Patients With Advanced or Recurrent Pancreatic Cancer With Mutated BRCA2 Gene

Who this might be right for
Pancreatic Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Testing effectiveness (Phase 2)Looking for participantsNCT06380660
What this trial is testing

Study of ACE-86225106 to Treat Patients With Advanced Solid Tumors

Who this might be right for
Solid Tumor, AdultBRCA1 MutationBRCA2 Mutation+3 more
Acerand Therapeutics (Shanghai) Limited 298
Not applicableActive Not RecruitingNCT02760849
What this trial is testing

Surgery in Preventing Ovarian Cancer in Patients With Genetic Mutations

Who this might be right for
Deleterious BARD1 Gene MutationDeleterious BRCA1 Gene MutationDeleterious BRCA2 Gene Mutation+11 more
M.D. Anderson Cancer Center 374
Not applicableActive Not RecruitingNCT02194387
What this trial is testing

Energy Balance Interventions in Increasing Physical Activity in Breast Cancer Gene Positive Patients, Lynch Syndrome-Positive Patients, CLL Survivors or High-Risk Family Members

Who this might be right for
Body Mass Index 25 or GreaterBRCA1 Gene MutationBRCA2 Gene Mutation+8 more
M.D. Anderson Cancer Center 337
Early research (Phase 1)Looking for participantsNCT05787587
What this trial is testing

PARG Inhibitor IDE161 in Participants With Advanced Solid Tumors

Who this might be right for
Advanced or Metastatic Solid TumorsBreast CancerOvarian Cancer+6 more
IDEAYA Biosciences 216
Not applicableLooking for participantsNCT04294927
What this trial is testing

TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention

Who this might be right for
BRCA1 Gene MutationBRCA2 Gene MutationRAD51C Gene Mutation+3 more
University Medical Center Nijmegen 3,000
Testing effectiveness (Phase 2)Study completedNCT02282345
What this trial is testing

Talazoparib Before Standard Therapy in Treating Patients With Invasive, BRCA-Mutated Breast Cancer

Who this might be right for
Breast AdenocarcinomaDeleterious BRCA1 Gene MutationDeleterious BRCA2 Gene Mutation+2 more
M.D. Anderson Cancer Center 36
Not applicableLooking for participantsNCT04095195
What this trial is testing

Registry of Subjects at Risk of Pancreatic Cancer

Who this might be right for
Familial Pancreatic CancerBRCA1 MutationBRCA2 Mutation+4 more
Associazione Italiana per lo Studio del Pancreas 1,000
Not applicableStudy completedNCT01948609
What this trial is testing

Prospective Research of Outcomes After Salpingo-oophorectomy

Who this might be right for
BRCA1 Gene MutationBRCA2 Gene Mutation
University of California, San Francisco 100
Early research (Phase 1)Study completedNCT03685331
What this trial is testing

HOPE: Olaparib, Palbociclib and Fulvestrant in Patients With BRCA Mutation-associated, HR+, HER2-metastatic Breast Cancer

Who this might be right for
Metastatic Breast CancerLocally Advanced Breast CancerAdvanced Breast Cancer+2 more
Abramson Cancer Center at Penn Medicine 9
Testing effectiveness (Phase 2)Active Not RecruitingNCT03344965
What this trial is testing

Olaparib In Metastatic Breast Cancer

Who this might be right for
Metastatic Breast CancerInvasive Breast CancerSomatic Mutation Breast Cancer (BRCA1)+7 more
Beth Israel Deaconess Medical Center 114
Not applicableStudy completedNCT02974842
What this trial is testing

Pre-Salpingo-Oophorectomy Pilot Study of MAKO 7 Device Performance

Who this might be right for
BRCA1 MutationBRCA2 MutationAtypia Suspicious for Malignancy
nVision Medical 50
Testing effectiveness (Phase 2)WithdrawnNCT01661868
What this trial is testing

Olaparib for Patients With Recurrent BRCA Deficient Ovarian Cancer

Who this might be right for
Ovarian CancerPeritoneal CancerFallopian Tube Cancer
Dana-Farber Cancer Institute
Large-scale testing (Phase 3)Active Not RecruitingNCT01905046
What this trial is testing

Metformin Hydrochloride in Preventing Breast Cancer in Patients With Atypical Hyperplasia or In Situ Breast Cancer

Who this might be right for
Atypical Ductal Breast HyperplasiaBRCA1 Mutation CarrierBRCA2 Mutation Carrier+2 more
Alliance for Clinical Trials in Oncology 86
Testing effectiveness (Phase 2)Ended earlyNCT04718675
What this trial is testing

KB-0742 in Participants With Relapsed or Refractory Solid Tumors Including Platinum Resistant High Grade Serous Ovarian Cancer (HGSOC)

Who this might be right for
Relapsed Solid TumorsRefractory Solid TumorsNon-Hodgkin Lymphoma+2 more
Kronos Bio 135
Not applicableStudy completedNCT01975363
What this trial is testing

Pilot Study of Curcumin for Women With Obesity and High Risk for Breast Cancer

Who this might be right for
Atypical Ductal Breast HyperplasiaBRCA1 Gene MutationBRCA2 Gene Mutation+2 more
Ohio State University Comprehensive Cancer Center 29
Not applicableStudy completedNCT04012229
What this trial is testing

IMpact of Breast cAncer Gene Status on Survival in Adjuvant Breast Cancer (IMBASSA)

Who this might be right for
Breast CancerBRCA1 MutationBRCA2 Mutation
Centre Hospitalier Universitaire de Besancon 2,295
Not applicableStudy completedNCT03470402
What this trial is testing

Decision Support for BRCA Testing in Ethnically Diverse Women

Who this might be right for
Breast CancerBRCA1 MutationBRCA2 Mutation+1 more
Columbia University 276
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