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Results for “p53 Mutations”

44 trials

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Showing 20 of 44 results

Early research (Phase 1)Not Yet RecruitingNCT07511062
What this trial is testing

Axatilimab Combined With Decitabine/Venetoclax for the Treatment of TP53-mutated AML

Who this might be right for
Acute Myeloid LeukemiaTP53 Gene Mutation
Northside Hospital, Inc. 32
Not applicableUnknownNCT04489706
What this trial is testing

Arsenic Trioxide in Recurrent and Metastatic Ovarian Cancer and Endometrial Cancer With P53 Mutation

Who this might be right for
Ovarian CancerEndometrial Cancer
Ruijin Hospital 20
Not applicableStudy completedNCT00505466
What this trial is testing

Transition From Research to Disclosure in Human Genetics

Who this might be right for
Education
M.D. Anderson Cancer Center 577
Testing effectiveness (Phase 2)UnknownNCT04695223
What this trial is testing

Arsenic Trioxide for Structural p53 Mutations

Who this might be right for
Arsenic Trioxidep53 MutationsRefractory Cancer+1 more
Shanghai Changzheng Hospital 30
Testing effectiveness (Phase 2)UnknownNCT04869475
What this trial is testing

Arsenic Trioxide in Refractory Solid Tumors With Rescuable p53 Mutation

Who this might be right for
Refractory Solid Tumors
Ruijin Hospital 20
Testing effectiveness (Phase 2)Ended earlyNCT03149679
What this trial is testing

The p53 Colorectal Cancer Trial

Who this might be right for
Colorectal Cancer MetastaticColorectal Cancer Stage IVTP53 Gene Mutation
Haukeland University Hospital 12
Not applicableStudy completedNCT04976439
What this trial is testing

Patogenic Mutation in 5 Genes

Who this might be right for
Colorectal CancerAPC Gene MutationTP53 Gene Mutation+3 more
Dr Cipto Mangunkusumo General Hospital 22
Not applicableLooking for participantsNCT04541654
What this trial is testing

Li-Fraumeni & TP53 (LiFT UP): Understanding and Progress

Who this might be right for
Li-Fraumeni SyndromeTP53 Gene MutationHereditary Cancer Syndrome+2 more
Dana-Farber Cancer Institute 1,500
Early research (Phase 1)Looking for participantsNCT06778863
What this trial is testing

CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

Who this might be right for
Advanced Solid TumorUnresectable Solid TumorMetastatic Solid Tumor+8 more
Clasp Therapeutics, Inc. 90
Not applicableLooking for participantsNCT07419893
What this trial is testing

Germline Genetic Testing of the TP53 Gene

Who this might be right for
TP53 Gene MutationMulti-Gene Transcriptional ProfilingTP53 Gene Germline Mutation Carrier
European Institute of Oncology 1,940
Testing effectiveness (Phase 2)Ended earlyNCT02203513
What this trial is testing

A Phase II Single Arm Pilot Study of the Chk1/2 Inhibitor (LY2606368) in BRCA1/2 Mutation Associated Breast or Ovarian Cancer, Triple Negative Breast Cancer, High Grade Serous Ovarian Cancer, and Metastatic Castrate-Resistant Prostate Cancer

Who this might be right for
Ovarian CancerBreast CancerProstate Cancer
National Cancer Institute (NCI) 111
Testing effectiveness (Phase 2)UnknownNCT00082979
What this trial is testing

Duct Endoscopy in Assessing Cellular Atypia in the Breast Duct Fluid of Women With a Genetic Risk for Breast Cancer

Who this might be right for
Breast Cancer
Royal Marsden NHS Foundation Trust 60
Early research (Phase 1)Active Not RecruitingNCT02432963
What this trial is testing

Vaccine Therapy and Pembrolizumab in Treating Patients With Solid Tumors That Have Failed Prior Therapy

Who this might be right for
Adult Solid NeoplasmBladder CarcinomaColon Carcinoma+14 more
City of Hope Medical Center 11
Testing effectiveness (Phase 2)Looking for participantsNCT06778187
What this trial is testing

Oral-ATO for TP53-mutated Myeloid Malignancies

Who this might be right for
Acute Myeloid LeukemiaMyelodysplastic NeoplasmChronic Myelomonocytic Leukemia+2 more
The University of Hong Kong 30
Very early researchEnded earlyNCT03272633
What this trial is testing

Irradiated Donor Cells Following Stem Cell Transplant in Controlling Cancer in Patients With Hematologic Malignancies

Who this might be right for
Acute Lymphoblastic LeukemiaAcute Myeloid Leukemia in RemissionHematopoietic Cell Transplantation Recipient+16 more
Rutgers, The State University of New Jersey 2
Not applicableStudy completedNCT02289326
What this trial is testing

Biomarker Monitoring in TP53 Mutation Carriers

Who this might be right for
Li-Fraumeni SyndromeHereditary Cancer SyndromesTP53 Gene Germline Mutation Carrier
Scripps Health 6
Testing effectiveness (Phase 2)Study completedNCT03732352
What this trial is testing

18F-FDG PET and Osimertinib in Evaluating Glucose Utilization in Patients with EGFR Activated Recurrent Glioblastoma

Who this might be right for
EGFR Gene AmplificationEGFR Gene MutationGlioblastoma+3 more
Jonsson Comprehensive Cancer Center 12
Large-scale testing (Phase 3)Not Yet RecruitingNCT05489848
What this trial is testing

Chemotherapy vs Chemoradiotherapy for Post-operative Endometrial Cancer Patients With P53-mutation

Who this might be right for
Endometrial Cancer
Fudan University 294
Not applicableStudy completedNCT01675102
What this trial is testing

Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) in 17p- Chronic Lymphocytic Leukemia (CLL)

Who this might be right for
CLL
European Society for Blood and Marrow Transplantation 41
Early research (Phase 1)Study completedNCT04293094
What this trial is testing

Study of AMG 650 in Adult Participants With Advanced Solid Tumors

Who this might be right for
Advanced Solid Tumors
Volastra Therapeutics, Inc. 66
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