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Results for “p53 Mutations”

45 trials

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Showing 20 of 45 results

Early research (Phase 1)Study completedNCT04293094
What this trial is testing

Study of AMG 650 in Adult Participants With Advanced Solid Tumors

Who this might be right for
Advanced Solid Tumors
Volastra Therapeutics, Inc. 66
Large-scale testing (Phase 3)Ended earlyNCT04159155
What this trial is testing

Various Treatments in Serous or p53 Abnormal Endometrial Cancer

Who this might be right for
Endometrial CarcinomaP53 MutationSerous Carcinoma
University Health Network, Toronto 11
Testing effectiveness (Phase 2)UnknownNCT03381781
What this trial is testing

Decitabine,Cytarabine and Arsenic Trioxide for Acute Myeloid Leukemia With p53 Mutations

Who this might be right for
Acute Myeloid LeukemiaP53 Mutation
Li Junmin 100
Early research (Phase 1)Looking for participantsNCT06778863
What this trial is testing

CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

Who this might be right for
Advanced Solid TumorUnresectable Solid TumorMetastatic Solid Tumor+8 more
Clasp Therapeutics, Inc. 90
Testing effectiveness (Phase 2)Active Not RecruitingNCT03611868
What this trial is testing

APG-115 in as a Monotherapy or Combination With Pembrolizumab in Patients With Metastatic Melanomas or Advanced Solid Tumors

Who this might be right for
Unresectable or Metastatic Melanoma or Advanced Solid TumorsMelanomaUveal Melanoma+5 more
Ascentage Pharma Group Inc. 230
Not applicableStudy completedNCT02289326
What this trial is testing

Biomarker Monitoring in TP53 Mutation Carriers

Who this might be right for
Li-Fraumeni SyndromeHereditary Cancer SyndromesTP53 Gene Germline Mutation Carrier
Scripps Health 6
Testing effectiveness (Phase 2)Looking for participantsNCT06088030
What this trial is testing

Arsenic Trioxide Combined With Chemotherapy for the Treatment of p53-mutated Pediatric Cancer

Who this might be right for
Pediatric CancerLi-Fraumeni Syndromep53 Mutations
Yang Li 50
Early research (Phase 1)Looking for participantsNCT06795009
What this trial is testing

Zanzalintinib in Combination With Paclitaxel in Recurrent High Grade Uterine Cancer

Who this might be right for
Uterine CancerEndometrial Cancer
Washington University School of Medicine 36
Large-scale testing (Phase 3)Not Yet RecruitingNCT05489848
What this trial is testing

Chemotherapy vs Chemoradiotherapy for Post-operative Endometrial Cancer Patients With P53-mutation

Who this might be right for
Endometrial Cancer
Fudan University 294
Not applicableUnknownNCT02140723
What this trial is testing

P53 and Response to Preoperative Radiotherapy for T2 and T3

Who this might be right for
Rectal Cancer
Medical University of Vienna 60
Testing effectiveness (Phase 2)Looking for participantsNCT06386146
What this trial is testing

JAB-30355 in Patients With Advanced Solid Tumors Harboring TP53 Y220C Mutation

Who this might be right for
Solid Tumors
Jacobio Pharmaceuticals Co., Ltd. 144
Testing effectiveness (Phase 2)Ended earlyNCT03149679
What this trial is testing

The p53 Colorectal Cancer Trial

Who this might be right for
Colorectal Cancer MetastaticColorectal Cancer Stage IVTP53 Gene Mutation
Haukeland University Hospital 12
Not applicableLooking for participantsNCT04541654
What this trial is testing

Li-Fraumeni & TP53 (LiFT UP): Understanding and Progress

Who this might be right for
Li-Fraumeni SyndromeTP53 Gene MutationHereditary Cancer Syndrome+2 more
Dana-Farber Cancer Institute 1,500
Testing effectiveness (Phase 2)Study completedNCT01357161
What this trial is testing

Adavosertib (MK-1775) in Combination With Paclitaxel and Carboplatin Versus Paclitaxel and Carboplatin Alone for Participants With Platinum-Sensitive Ovarian Tumors With the P53 Gene Mutation (MK-1775-004)

Who this might be right for
Ovarian Cancer
Merck Sharp & Dohme LLC 136
Testing effectiveness (Phase 2)Looking for participantsNCT06778187
What this trial is testing

Oral-ATO for TP53-mutated Myeloid Malignancies

Who this might be right for
Acute Myeloid LeukemiaMyelodysplastic NeoplasmChronic Myelomonocytic Leukemia+2 more
The University of Hong Kong 30
Large-scale testing (Phase 3)WithdrawnNCT03377725
What this trial is testing

Decitabine and Arsenic Trioxide for Myelodysplastic Syndrome(MDS)

Who this might be right for
Myelodysplastic SyndromesP53 Mutation
Li Junmin
Not applicableStudy completedNCT00505466
What this trial is testing

Transition From Research to Disclosure in Human Genetics

Who this might be right for
Education
M.D. Anderson Cancer Center 577
Testing effectiveness (Phase 2)WithdrawnNCT06654050
What this trial is testing

Alrizomadlin (APG-115) in Subjects With BAP1 Cancer Syndrome and Early-Stage Mesothelioma

Who this might be right for
MesotheliomaMalignant Mesothelioma (MM)Early-stage Mesothelioma+3 more
National Cancer Institute (NCI)
Testing effectiveness (Phase 2)Looking for participantsNCT04585750
What this trial is testing

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

Who this might be right for
Advanced Solid TumorAdvanced Malignant NeoplasmMetastatic Cancer+27 more
PMV Pharmaceuticals, Inc 300
Testing effectiveness (Phase 2)UnknownNCT04695223
What this trial is testing

Arsenic Trioxide for Structural p53 Mutations

Who this might be right for
Arsenic Trioxidep53 MutationsRefractory Cancer+1 more
Shanghai Changzheng Hospital 30
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