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Results for “p53 Mutations”

41 trials

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Showing 20 of 41 results

Not applicableStudy completedNCT00001148
What this trial is testing

Detecting Malignant Brain Tumor Cells in the Bloodstream During Surgery to Remove the Tumor

Who this might be right for
AstrocytomaGlioblastomaGlioma
National Institute of Neurological Disorders and Stroke (NINDS) 25
Early research (Phase 1)Looking for participantsNCT06778863
What this trial is testing

CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

Who this might be right for
Advanced Solid TumorUnresectable Solid TumorMetastatic Solid Tumor+8 more
Clasp Therapeutics, Inc. 90
Testing effectiveness (Phase 2)Study completedNCT02272790
What this trial is testing

Adavosertib Plus Chemotherapy in Platinum-Resistant Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Who this might be right for
Ovarian, Fallopian Tube, Peritoneal Cancer, P53 Mutation
AstraZeneca 95
Testing effectiveness (Phase 2)Study completedNCT01357161
What this trial is testing

Adavosertib (MK-1775) in Combination With Paclitaxel and Carboplatin Versus Paclitaxel and Carboplatin Alone for Participants With Platinum-Sensitive Ovarian Tumors With the P53 Gene Mutation (MK-1775-004)

Who this might be right for
Ovarian Cancer
Merck Sharp & Dohme LLC 136
Very early researchEnded earlyNCT03272633
What this trial is testing

Irradiated Donor Cells Following Stem Cell Transplant in Controlling Cancer in Patients With Hematologic Malignancies

Who this might be right for
Acute Lymphoblastic LeukemiaAcute Myeloid Leukemia in RemissionHematopoietic Cell Transplantation Recipient+16 more
Rutgers, The State University of New Jersey 2
Testing effectiveness (Phase 2)Looking for participantsNCT06386146
What this trial is testing

JAB-30355 in Patients With Advanced Solid Tumors Harboring TP53 Y220C Mutation

Who this might be right for
Solid Tumors
Jacobio Pharmaceuticals Co., Ltd. 144
Early research (Phase 1)Active Not RecruitingNCT02432963
What this trial is testing

Vaccine Therapy and Pembrolizumab in Treating Patients With Solid Tumors That Have Failed Prior Therapy

Who this might be right for
Adult Solid NeoplasmBladder CarcinomaColon Carcinoma+14 more
City of Hope Medical Center 11
Testing effectiveness (Phase 2)Looking for participantsNCT06778187
What this trial is testing

Oral-ATO for TP53-mutated Myeloid Malignancies

Who this might be right for
Acute Myeloid LeukemiaMyelodysplastic NeoplasmChronic Myelomonocytic Leukemia+2 more
The University of Hong Kong 30
Not applicableStudy completedNCT01675102
What this trial is testing

Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) in 17p- Chronic Lymphocytic Leukemia (CLL)

Who this might be right for
CLL
European Society for Blood and Marrow Transplantation 41
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06654050
What this trial is testing

Alrizomadlin (APG-115) in Subjects With BAP1 Cancer Syndrome and Early-Stage Mesothelioma

Who this might be right for
MesotheliomaMalignant Mesothelioma (MM)Early-stage Mesothelioma+3 more
National Cancer Institute (NCI) 15
Testing effectiveness (Phase 2)Ended earlyNCT03149679
What this trial is testing

The p53 Colorectal Cancer Trial

Who this might be right for
Colorectal Cancer MetastaticColorectal Cancer Stage IVTP53 Gene Mutation
Haukeland University Hospital 12
Large-scale testing (Phase 3)Ended earlyNCT04159155
What this trial is testing

Various Treatments in Serous or p53 Abnormal Endometrial Cancer

Who this might be right for
Endometrial CarcinomaP53 MutationSerous Carcinoma
University Health Network, Toronto 11
Not applicableUnknownNCT04489706
What this trial is testing

Arsenic Trioxide in Recurrent and Metastatic Ovarian Cancer and Endometrial Cancer With P53 Mutation

Who this might be right for
Ovarian CancerEndometrial Cancer
Ruijin Hospital 20
Early research (Phase 1)Looking for participantsNCT06795009
What this trial is testing

Zanzalintinib in Combination With Paclitaxel in Recurrent High Grade Uterine Cancer

Who this might be right for
Uterine CancerEndometrial Cancer
Washington University School of Medicine 36
Early research (Phase 1)Study completedNCT04293094
What this trial is testing

Study of AMG 650 in Adult Participants With Advanced Solid Tumors

Who this might be right for
Advanced Solid Tumors
Volastra Therapeutics, Inc. 66
Large-scale testing (Phase 3)Study completedNCT01464086
What this trial is testing

LIFSCREEN : Evaluation of Whole Body MRI for Early Detection of Cancers in Subjects With P53 Mutation (Li-Fraumeni Syndrome)

Who this might be right for
Li Fraumeni Syndrome
Gustave Roussy, Cancer Campus, Grand Paris 107
Large-scale testing (Phase 3)WithdrawnNCT03377725
What this trial is testing

Decitabine and Arsenic Trioxide for Myelodysplastic Syndrome(MDS)

Who this might be right for
Myelodysplastic SyndromesP53 Mutation
Li Junmin
Not applicableNot Yet RecruitingNCT06900582
What this trial is testing

SENTInel Node Mapping Versus Comprehensive Lymphadenectomy in P53-Mutated Endometrial Cancer: a Non-Inferiority Randomized Trial

Who this might be right for
LymphadenectomyEndometrial CancerGene, P53+1 more
University Hospital, Strasbourg, France 374
Not applicableStudy completedNCT00505466
What this trial is testing

Transition From Research to Disclosure in Human Genetics

Who this might be right for
Education
M.D. Anderson Cancer Center 577
Early research (Phase 1)Ended earlyNCT05622058
What this trial is testing

ALRN-6924 for Protection of Chemotherapy-Induced Side Effects in Patients With TP53-Mutant Breast Cancer

Who this might be right for
Prevention of Chemotherapy-induced Myelosuppression
Aileron Therapeutics, Inc. 6
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