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Results for “pMMR”

143 trials

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Showing 20 of 143 results

Large-scale testing (Phase 3)Looking for participantsNCT06989112
What this trial is testing

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

Who this might be right for
Endometrial Cancer
AstraZeneca 600
Large-scale testing (Phase 3)Looking for participantsNCT06791512
What this trial is testing

MFOLFOX6 + Bevacizumab + PD-1 Monoclonal Antibody Vs. mFOLFOX6 in Locally Advanced pMMR/MSS CRC

Who this might be right for
Colorectal Cancer (CRC)pMMR/MSS Adenocarcinoma of the Colon or Rectum
Jun Huang 166
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06014944
What this trial is testing

Short-course Radiotherapy Combined With Furoquintinib and PD-1 Monoclonal Antibody

Who this might be right for
Rectal Cancer
Changhai Hospital 30
Testing effectiveness (Phase 2)UnknownNCT04724239
What this trial is testing

Sintilimab and Chidamide in Combination With or Without IBI305 in Advanced or Metastatic pMMR/MSS Colorectal Carcinoma

Who this might be right for
Advanced Microsatellite Stable Colorectal CancerMetastatic Microsatellite-stable Colorectal Cancer
Sun Yat-sen University 48
Testing effectiveness (Phase 2)Looking for participantsNCT05731726
What this trial is testing

Serplulimab Combined With CAPEOX + Celecoxib as Neoadjuvant Treatment for Locally Advanced Rectal Cancer

Who this might be right for
pMMRMSSMSI-L+1 more
Zhejiang University 50
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07170982
What this trial is testing

Fruquintinib Combined With Standard Chemotherapy Versus Standard Chemotherapy as First-line Treatment for Advanced pMMR Endometrial Cancer

Who this might be right for
Endometrial Cancer
Sun Yat-sen University 128
Testing effectiveness (Phase 2)Study completedNCT04221555
What this trial is testing

Trial of Neoadjuvant Durvalumab Plus Docetaxel, Oxaliplatin, S-1 Followed by Surgery and Adjuvant Durvalumab Plus S-1 Chemotherapy in Potentially Resectable MMR Proficient Gastric or Gastroesophageal Junction Adenocarcinoma

Who this might be right for
Resectable Gastric or Gastroesophageal Junction Adenocarcinoma
Asan Medical Center 68
Early research (Phase 1)Looking for participantsNCT07510308
What this trial is testing

Clinical Study of MSH2-/- Tumor Cell Vaccines for Advanced pMMR Colorectal Cancer Patients

Who this might be right for
pMMR/MSS Advanced Colorectal Cancer
West China Hospital 9
Testing effectiveness (Phase 2)Looking for participantsNCT07448142
What this trial is testing

Low-Dose Radiotherapy to Sensitize Pucotenlimab Plus CAPEOX for pMMR Locally Advanced Rectal Cancer

Who this might be right for
Colorectal Cancer (CRC)
Sun Yat-sen University 50
Testing effectiveness (Phase 2)UnknownNCT04527068
What this trial is testing

QL1101 in Combination With JS001 in Patients With pMMR/MSS Refractory Metastatic Colorectal Cancer

Who this might be right for
Refractory Metastatic Colorectal CancerpMMRMSS
Second Affiliated Hospital, School of Medicine, Zhejiang University 50
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07394192
What this trial is testing

Short-Course Radiotherapy With Tumor-Draining Lymph Node Preservation Followed by PD-1 Inhibitors in pMMR/MSS Stage II-III Rectal Cancer

Who this might be right for
Rectal CancerRadiotherapyPD-1 Inhibitor
Peking University Cancer Hospital & Institute 44
Testing effectiveness (Phase 2)Looking for participantsNCT06830239
What this trial is testing

Phase II Study of Neoadjuvant Dostarlimab in Patients With Untreated T3-4N0-2 or Stage III pMMR/MSS Resectable Colon Cancer

Who this might be right for
Colon Cancer Stage III
Universitaire Ziekenhuizen KU Leuven 10
Testing effectiveness (Phase 2)Looking for participantsNCT05965531
What this trial is testing

Treating Locally Advanced Rectal Cancer With TAS-102 Chemotherapy Plus Neoadjuvant Radiotherapy

Who this might be right for
Rectal Cancer
Sun Yat-sen University 65
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07527520
What this trial is testing

Neoadjuvant Moderately Hypofractionated Radiotherapy Combined With Chemotherapy and Immunotherapy for High-risk pMMR/MSS Locally Advanced Rectal Cancer: A Prospective, Multi-center Randomized Control Phase II Trial

Who this might be right for
Rectal CancerModerately Hypofractionated RadiotherapySerplulimab+1 more
Fudan University 165
Not applicableNot Yet RecruitingNCT06823323
What this trial is testing

The Study on the Efficacy and Safety of Lactobacillus Johnsonii in Combination with CapeOX and Pembrolizumab for the Treatment of MSS/pMMR Metastatic Colorectal Cancer.

Who this might be right for
Metastatic Colorectal Cancer (CRC)
Second Affiliated Hospital, School of Medicine, Zhejiang University 150
Testing effectiveness (Phase 2)Looking for participantsNCT07230639
What this trial is testing

Node-Sparing Hypofractionated Radiotherapy Plus Chemotherapy and PD-1 Inhibitor in pMMR/MSS High-Risk Locally Advanced Colon Cancer: A Prospective, Randomized, Phase II Trial

Who this might be right for
Neoadjuvant TherapiesImmune Checkpoint TherapyRadiotherapy
Sixth Affiliated Hospital, Sun Yat-sen University 52
Not applicableUnknownNCT02986568
What this trial is testing

Efficacy of the Standard Treatment and Fusion Ontogenetic Surgery for Gynecologic Cancers

Who this might be right for
Cervical CancerUterine Cancer
Seoul National University Hospital 380
Not applicableLooking for participantsNCT06890273
What this trial is testing

NIS to Examine the Effectiveness and Safety of Durvalumab and Olaparib in Patients With Endometrial Cancer (DUOLife)

Who this might be right for
Endometrial Cancer
AstraZeneca 150
Large-scale testing (Phase 3)Looking for participantsNCT06733038
What this trial is testing

FOLFOXIRI Plus Bevacizumab With or Without Atezolizumab as 1st Line Treatment of pMMR and IS IC-High Metastatic Colorectal Cancer Patients.

Who this might be right for
Colorectal Cancer
Gruppo Oncologico del Nord-Ovest 238
Testing effectiveness (Phase 2)Looking for participantsNCT05872685
What this trial is testing

Perioperative Chemotherapy Combined With Serplulimab or Placebo for pMMR Locally Advanced Gastric Adenocarcinoma (FOCUS-05)

Who this might be right for
Adenocarcinoma of the StomachAdenocarcinoma of Esophagogastric JunctionProficient Mismatch Repair
Yu jiren 314
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