Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “pMMR/MSS Locally Advanced Rectal Cancer”

43 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 43 results

Testing effectiveness (Phase 2)UnknownNCT06304987
What this trial is testing

Neoadjuvant Chemoradiotherapy Combined With PD-1 Inhibitor and PCSK9 Inhibitor for pMMR/MSS Locally Advanced Mid-low Rectal Cancer

Who this might be right for
Locally Advanced Rectal Cancer
Beijing Friendship Hospital 50
Testing effectiveness (Phase 2)UnknownNCT06239870
What this trial is testing

Single-arm, Single-center, Exploratory Phase II Clinical Study of Envafolimab Combined With Chemoradiotherapy in the Treatment of Locally Advanced pMMR/MSS Rectal Cancer

Who this might be right for
Envafolimab Combined With Chemoradiotherapy in the Treatment of Locally Advanced pMMR/MSS Rectal Cancer
Yunnan Cancer Hospital 35
Testing effectiveness (Phase 2)Looking for participantsNCT06864013
What this trial is testing

SCRT Combined With Chemotherapy and Iparomlimab and Tuvonralimab in MSS or pMMR Patients With Locally Advanced Rectal Cancer

Who this might be right for
Locally Advanced Rectal Cancer (LARC)
First Affiliated Hospital of Zhejiang University 116
Testing effectiveness (Phase 2)Looking for participantsNCT07005570
What this trial is testing

Short-course Radiotherapy Followed by Sequential Chemotherapy With or Without PD-1 Monoclonal Antibody and Bevacizumab as Total Neoadjuvant Therapy in pMMR/MSS Locally Advanced Rectal Cancer （SPARK）

Who this might be right for
pMMR/MSS Locally Advanced Rectal Cancer
Dechang Diao 86
Testing effectiveness (Phase 2)Looking for participantsNCT07458529
What this trial is testing

Neoadjuvant Chemoradiotherapy Plus Tislelizumab With or Without Probio-M9 in pMMR/MSS Locally Advanced Rectal Cancer

Who this might be right for
Rectal Cancer, AdenocarcinomaNeoadjuvant TherapyImmunotherapy+3 more
Seventh Medical Center of PLA General Hospital 50
Large-scale testing (Phase 3)Not Yet RecruitingNCT07595276
What this trial is testing

Comparing Efficacy and Safety of Enlituo® Versus Erbitux® Plus FOLFOX in Locally Advanced/Metastatic Colorectal Cancer With RAS/BRAF Wild-type and MSS/pMMR Status.

Who this might be right for
Colorectal Cancer
Taizhou Mabtech Pharmaceutical Co.,Ltd 608
Testing effectiveness (Phase 2)Active Not RecruitingNCT06933251
What this trial is testing

PCSK9 Inhibitor and PD-1 Inhibitor Combined With Neoadjuvant Chemoradiotherapy for pMMR/MSS Locally Advanced Rectal Cancer

Who this might be right for
Locally Advanced Rectal Cancer (LARC)
Guangdong Provincial People's Hospital 30
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07651007
What this trial is testing

Short-course RT Followed by NALIRIFOX Plus Pucotenlimab as Neoadjuvant Therapy for High-risk Locally Advanced Rectal Cancer With MSS/pMMR

Who this might be right for
Advanced Rectal Cancer
Wang Xin 29
Testing effectiveness (Phase 2)Looking for participantsNCT07527026
What this trial is testing

A Single-arm Phase II Clinical Study of Camrelizumab Combined With Long-course Chemoradiotherapy for Total Neoadjuvant Therapy in Locally Advanced Low pMMR/MSS Rectal Cancer

Who this might be right for
Locally Advanced Rectal Cancer
Chinese PLA General Hospital 44
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07175636
What this trial is testing

QL1706 With Short-Course Radiotherapy and Chemotherapy for MSS Rectal Cancer

Who this might be right for
Locally Advanced Rectal Cancer (LARC)Mismatch Repair-Proficient (pMMR) Rectal CancerNon-metastatic Rectal Cancer
Sun Yat-sen University 66
Testing effectiveness (Phase 2)Looking for participantsNCT06923345
What this trial is testing

Modified Long-Course Radiotherapy Followed by Chemotherapy and PD-1 Inhibitor for MSS/pMMR High-risk Mid/Low LARC (MODIFI-RC-I)

Who this might be right for
Rectal CancerNeoadjuvant TherapiesImmune Checkpoint Therapy+1 more
Sixth Affiliated Hospital, Sun Yat-sen University 80
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07779694
What this trial is testing

16-Hour Fasting Plus Serplulimab and CAPEOX as Neoadjuvant Therapy in pMMR/MSS Advanced Mid-to-Low Rectal Cancer

Who this might be right for
pMMR/MSSLocally Advanced Rectal CarcinomaFasting, Intermittent
Zhejiang University 51
Testing effectiveness (Phase 2)Looking for participantsNCT06911684
What this trial is testing

Radiotherapy Plus Iparomlimab and Tuvonralimab (QL1706), Regorafenib, and CAPOX as Neoadjuvant Therapy for pMMR/MSS LARC.

Who this might be right for
Rectal Cancer Patients
Sun Yat-sen University 88
Testing effectiveness (Phase 2)UnknownNCT04989855
What this trial is testing

Fruquintinib Plus PD-1 Antibody in pMMR / MSS Locally Advanced Rectal Cancer (LARC) With High Immune Score

Who this might be right for
Locally Advanced Rectal Cancer
Sun Yat-sen University 48
Large-scale testing (Phase 3)Not Yet RecruitingNCT06832917
What this trial is testing

Short-course Radiation (SCRT) Followed by 6 Cycles of Cadonilimab Plus MFOLFOX6 As Neoadjuvant Therapy for Patients with Locally Advanced Rectal Cancer (LARC): a Multicenter, Two-arm Parallel, Open-label, Randomised Phase III Trial (NeoCaCRT-III)

Who this might be right for
Rectal Cancer
Wan He 238
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06919510
What this trial is testing

A Phase ll Study of Neoadjuvant Short-course Radiotherapy Followed by Ivonescimab and Chemotherapy in pMMR/MSS Locally Advanced Rectal Cancer

Who this might be right for
Rectal Adenocarcinoma
Sun Yat-sen University 90
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07765667
What this trial is testing

NCT + PD1 + Ketogenic Diet and/or Vitamin C for LARC

Who this might be right for
Rectal AdenocarcinomaHigh-Risk CancerMSS
Sixth Affiliated Hospital, Sun Yat-sen University 100
Testing effectiveness (Phase 2)Looking for participantsNCT07622771
What this trial is testing

Neoadjuvant Radiotherapy Combined With NALIRIFOX and Adebrelimab in pMMR/MSS Locally Advanced Rectal Cancer: A Prospective, Randomized, Phase II Clinical Trial

Who this might be right for
Rectal Cancers
Sun Yat-sen University 84
Testing effectiveness (Phase 2)UnknownNCT05815303
What this trial is testing

XELOX Combined With Cadonilimab Versus XELOX as Neoadjuvant Treatment for Locally Advanced, pMMR Rectal Cancer

Who this might be right for
Rectal CancerMSS
Cancer Institute and Hospital, Chinese Academy of Medical Sciences 92
Testing effectiveness (Phase 2)Looking for participantsNCT07448142
What this trial is testing

Low-Dose Radiotherapy to Sensitize Pucotenlimab Plus CAPEOX for pMMR Locally Advanced Rectal Cancer

Who this might be right for
Colorectal Cancer (CRC)
Sun Yat-sen University 50
Next Page