A Randomized Study of Activity, Safety, and Tolerance of Oral Ro 24-7429 (Tat Antagonist) in Patients With HIV Infection

Inclusion Criteria Concurrent Medication: Allowed: * Chemoprophylaxis for P. carinii pneumonia, TB, and mucocutaneous candidiasis. * Methadone maintenance. * Hormonal contraceptives. Patients must have: * HIV-1 seropositivity. * CD4 count 50 - 500 cells/mm3. * Life expectancy of at least 24 weeks. * Stable weight (+/- 2 kg) by 28 days prior to study entry (by history). NOTE: * At least 50 percent of patients must be p24 antigen positive (\>= 50 pg/ml). Exclusion Criteria Co-existing Condition: Patients with the following symptoms and conditions are excluded: * Known or suspected hypersensitivity to benzodiazepines. * Presence of any malignancy other than basal cell carcinoma or limited cutaneous Kaposi's sarcoma (defined as no more than five lesions with no mucosal involvement). * Ongoing diarrhea, defined as more than 2 liquid stools per day. * History, physical exam, or laboratory results consistent with a subclinical AIDS-defining opportunistic infection. * Grade 2 or greater signs and symptoms of AIDS Dementia Complex. * Evidence of clinically significant cardiac, respiratory, hepatic, gastrointestinal, endocrine, hematologic, psychiatric, neurologic, dermatologic, or allergic disease. Concurrent Medication: Excluded: * Chronic suppressive therapy for CMV, MAI, toxoplasmosis, cryptococcosis, cryptosporidiosis, coccidioidomycosis, and histoplasmosis. * ddC, ddI, AZT (except for control groups) or other experimental antiretrovirals or immunomodulating agents. * Other medications excluded from the study. Patients with the following prior conditions are excluded: * History of serious adverse reactions to benzodiazepines. * History of intolerance to AZT at 600 mg/day or less or ddI at 400 mg/day or less. * History of unexplained fever, defined as a temperature of 38.5 deg C or greater with or without night sweats for more than 7 of the past 28 days. Prior Medication: Excluded: * Benzodiazepines within 14 days prior to study entry. Active drug or alcohol abuse that would interfere with study compliance.