The purpose of this study is to see if it is safe and effective to give HIV-infected patients a new combination of anti-HIV drugs taken once daily.
Patients receive a treatment regimen of adefovir dipivoxil, didanosine, efavirenz, and lamivudine for 48 weeks. During the study, patients are evaluated for changes from baseline in plasma HIV-1 RNA and lymphocyte subsets and for the development of adverse experiences and laboratory toxicities. At Weeks 8, 12, 24, and 48, patients are assessed for adherence to study treatment with a questionnaire. Patients who experience virologic failure are discontinued from the study. Patients who experience treatment intolerance may have their antiretroviral treatment regimens changed. After Week 48, patients with documented virologic response are eligible to continue receiving study treatment.
Study Type
INTERVENTIONAL
Purpose
TREATMENT
Enrollment
25
Pacific Oaks Med Group
Beverly Hills, California, United States
Univ of Colorado / Health Science Ctr
Denver, Colorado, United States
AIDS Research Consortium of Atlanta
Atlanta, Georgia, United States
Brown Univ School of Medicine
Providence, Rhode Island, United States
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Hampton Roads Med Specialists
Hampton, Virginia, United States