Study of BSF 208075 Evaluating Exercise Capacity in Patients With Pulmonary Arterial Hypertension

--Disease Characteristics-- * Current diagnosis of either PPH or PAH secondary to the scleroderma spectrum of disease (e.g., mixed connective tissue disease, systemic lupus erythematosus, systemic sclerosis, or overlap syndrome), anorexigen use, or human immunodeficiency virus (HIV) infection at the time of screening * By means of a right heart catheterization, completed prior to Screening Visit subjects must meet all of the following hemodynamic criteria: * Mean pulmonary arterial pressure of \>/= 25 mmHg * Pulmonary vascular resistance \>3 mmHg/L/min * Pulmonary capillary wedge pressure or left ventricle end diastolic pressure of \<15 mmHg * Stable on conventional therapy for PAH, including diuretics, digoxin, or supplemental oxygen, for at least one month prior to the Screening Visit * Subjects with a diagnosis of HIV must have stable disease status at the time of screening. The subject may be enrolled if they meet the definition of a stable HIV status defined as: * No addition of medications for treatment of HIV in the last two months * No active opportunistic infection at the time of screening * No hospitalizations due to HIV within the past four weeks * Able to walk at least 150 meters, but no more than 450 meters, in a six minute walk test at the time of the Screening Visit * No pulmonary arterial hypertension due to or associated with congenital heart disease, interstitial lung disease, chronic obstructive pulmonary disease, or chronic thrombotic and/or embolic disease, as documented by a historical echocardiogram, chest X-ray, ventilation/perfusion (V/Q) scan, and/or pulmonary arteriogram * No subjects who have, as measured by a historical pulmonary function test: * Total lung capacity (TLC) \<70% of predicted normal or; * Forced expiratory volume in one second (FEV1) \<65% of predicted normal --Other Criteria-- * Subjects are excluded if they have: * A serum ALT or AST lab value that is greater than 1.5 times the upper limit of normal at any time during the Screening Period * Contraindication to treatment with an endothelin receptor antagonist * Demonstrated noncompliance with previous medical regimens * A recent history of abusing alcohol or illicit drugs * Participated in a clinical study involving another investigational drug or device within four weeks before the Screening Visit or at any time during the study --Patient Characteristics-- * Women of childbearing potential must: * Have a negative serum pregnancy test at the Screening Visit and a negative urine pregnancy test at the Randomization Visit. Women who are surgically sterile or those who are post-menopausal for at least two years are not considered to be of childbearing potential * Agree to use a reliable double barrier method of contraception until study completion and for at least four weeks following their final study visit * All males must be informed of the potential risks of testicular tubular atrophy and infertility associated with taking this study drug and queried regarding his understanding of the potential risks as described in the Informed Consent Form Excluded: * Pregnant or breastfeeding * Have a history of malignancies within the past five years, with the exception of basal cell carcinoma of the skin or in situ carcinoma of the cervix * Any other disease which, in the investigators opinion, may adversely affect the safety of the subject and/or efficacy of the study drug or severely limit the lifespan of the subject --Prior/Concurrent Therapy-- * Stable on conventional therapy for PAH, including diuretics, digoxin, or supplemental oxygen, for at least one month prior to the Screening Visit Excluded Therapies: * IV inotropes within two weeks prior to the Screening Visit * Chronic prostanoid therapy (epoprostenol, treprostinil, iloprost, beraprost, or any other investigational prostacyclin derivative) within four weeks prior to the Screening Visit * Bosentan within four weeks prior to the Screening Visit