Adjuvant Hepatic Arterial Infusion and Combination Chemotherapy in Treating Patients With Resectable Hepatic Metastases From Colorectal Cancer

Subject Inclusion Criteria: * History of histologically confirmed colorectal adenocarcinoma metastatic to the liver with no clinical or radiographic evidence of extrahepatic disease. Confirmation of diagnosis must be performed at MSKCC. * Potentially completely resectable hepatic metastases without current evidence of other metastatic disease. * Abdominal and pelvic CT scans and chest CT or x-ray within 6 weeks prior to registration. (MRI of abdomen may be substituted for CT of abdomen.) * Lab values within 14 days prior to registration: * WBC ≥ 3.0 K/ul * ANC \>1.5 K/ul * Platelets ≥ 100 K/ul * Total bilirubin ≤ 1.5 mg/dl. * Prior chemotherapy is acceptable if last dose given ≥ 3 weeks prior to registration to this study. * KPS ≥ 60% * Signed informed consent. Subject Exclusion Criteria: * Prior radiation to the liver. (Prior radiation therapy to the pelvis is acceptable if completed at least 4 weeks prior to registration.) * Active infection, ascites, hepatic encephalopathy * Prior oxaliplatin or cisplatin or HAI FUDR * Female patients who are pregnant or lactating