Treatment of Melasma With Jessner's Solution vs. Trichloroacetic Acid

Emory University19 enrolled

Overview

Melasma is an acquired discoloration of the skin characterized by brown patches. Chemical peels using agents such as Jessner's solution and trichloroacetic acid (TCA) are commonly used to treat melasma. A chemical peel involves applying the peeling agent to the skin for a short period. The skin will peel similar to a sunburn, and moisturizers are applied to the skin. Although both agents are well-accepted, there have been no good comparisons of the two agents. The purpose of this study is determine if there is a difference in the effectiveness of these two agents.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Melasma

Interventions

Jessner's solution chemical peelPROCEDURE

Trichloroacetic acid chemical peelPROCEDURE

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adults \> 18 years old * Clinical diagnosis of melasma * Mental capacity to give informed consent Exclusion Criteria: * Pregnancy * H/o allergy to Jessner's solution, tricholoracetetic acid, tretinoin, or hydroquinone * Active dermatitis * Presence of cutaneous infection

Locations (1)

Emory University Dermatology Clinic

Atlanta, Georgia, United States

Outcomes

Primary Outcomes

Clinical efficacy by clinician's evaluation

Hyperpigmenation Global Score

Time frame: 3 months

Secondary Outcomes

Efficacy by subject's evaluation

Hyperpigmentation Global Score

Time frame: 3 months

Data from ClinicalTrials.gov

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