The purpose of this study is to investigate effect of candesartan based therapy on percent change of B type natriuretic peptides(BNP) level in the subjects with hypertension and left ventricular hypertrophy.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
315
16 mg once daily in oral tablet form
32 mg once daily in oral tablet form
5 mg once daily in oral tablet form
Research Site
Busan, South Korea
Research Site
Cheonan, South Korea
Research Site
Cheongju-si, South Korea
Research Site
Chunbuk, South Korea
Percent Change of B Type Natriuretic Peptides (BNP) Level
Change of B Type Natriuretic Peptides Level of the Subjects With Hypertension and Left Ventricular Hypertrophy (LVH) Treated With Candesartan Based Therapy for 24 Weeks was calculated just as the later time point minus the earlier time point. No specific calculation was used.
Time frame: At Baseline and 24 weeks
LVH(Left Ventricular Hypertrophy) Regression by Echocardiac Parameter, Left Ventricular Mass Index
Change of Left Ventricular Hypertrophy(LVH) by Echocardiac Parameter, Left Ventricular mass Index (LVMI) was calculated and collected through the way of Last Observational carried forward. LVH/Index was calculated like this: Divide LV mass with Body Surface Area.
Time frame: At Baseline and 24 weeks
Change of Systolic Blood Pressure (SBP)
Change of Systolic Blood Pressure was calculated and collected through the way of Last Observational carried forward.
Time frame: At Baseline and 24 weeks
Change of Diastolic Blood Pressure (DBP)
Change of Diastolic Blood Pressure was calculated and collected through the way of Last Observational carried forward. Only who has diastolic blood pressure data both baseline and follow up was analyzed. Most of patient who enrolled, 302 have a data.
Time frame: At Baseline and 24 weeks
Percent Change of proBNP(B Type Natriuretic Peptides) in Patients Treated With Candesartan Only
Percent change of proBNP(B type Natriuretic Peptides) was calculated and collected through the way of Last Observational carried forward.
Time frame: At Baseline and 24 weeks
Percent Change of proBNP(B Type Natriuretic Peptides) in Patients With Candesartan Plus Felodipine
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10 mg once daily in oral tablet form
Research Site
Daegu, South Korea
Research Site
Daejeon, South Korea
Research Site
Gyungsangnamdo, South Korea
Research Site
Jeonju, South Korea
Research Site
Kwangju, South Korea
Research Site
Pusan, South Korea
...and 1 more locations
Percent change of proBNP(B type Natriuretic Peptides) was calculated and collected through the way of Last Observational carried forward.
Time frame: At Baseline and 24 weeks