Olmesartan Medoxomil and Diabetic Nephropathy

Inclusion Criteria: * Male or female European out-patients * Greater than or equal to 30 years of age * Type 2 diabetes first diagnosed at greater than or equal to 30 years of age * Urinary protein excretion between 200-4000 mg/day exclusive * Mean sitting dBP less than or equal to 110 mgHg * Medically justifiable to withdraw antihypertensive treatment due to poor tolerability or inefficacy of previous treatment, or verification that treatment is still necessary Exclusion Criteria: * Females pregnant, nursing or planning to become pregnant or were of childbearing potential and not using acceptable methods of contraception * Secondary forms of hypertension other than diabetic nephropathy, malignant hypertension or patients with sitting dBP exceeding 110 mmHg or sitting sBP exceeding 200 mmHg * ECG evidence of 2nd or 3rd degree AV-block, atrial fibrillation, cardiac arrhythmia (requiring therapy) or bradycardia * Presence of significant cardiovascular disease * Significant cerebrovascular disease, gastrointestinal, haematological or hepatic disease or myocardial infarction in last 12 months or a previous history of any serious underlying disease * Concurrent renal disease, nephrectomy and/or renal transplant, serum creatinine level greater than or equal to 2.0 mg/dL or creatinine clearance CLCR less than or equal to 50 mL/min * Clinically significant lab abnormalities (ASAT/SGOT, ALAT/SGPT and γ-GT ) * Serum potassium level \< 2.5 mmol/L or \> 5.5 mmol/L * Treatment of concurrent indications with drugs or medication which could have influenced BP * History of hypersensitivity, lack of response or contraindication to Ang II-antagonists, HCTZ or atenolol, or hypersensitivity to related drugs (cross-allergy)