Intranasal Steroids and the Nasal Ocular Response

University of Chicago20 enrolled

Overview

Eye symptoms of tearing, redness and itch frequently occur in patients with allergic rhinitis or hayfever. The purpose of this study is to learn whether placing allergen (the substance that causes allergies) in the nose several days in a row will cause an increase in eye symptoms and whether receiving a nasal steroid spray will prevent these eye symptoms.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Seasonal Allergic Rhinitis

Interventions

fluticasone furoateDRUG

corticosteroid nasal spray

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria 1. Males and females between 18 and 45 years of age. 2. History of grass and/or ragweed allergic rhinitis. 3. Positive skin test to grass and/or ragweed antigen. 4. Positive response to screening nasal challenge. Exclusion Criteria 1. Physical signs or symptoms suggestive of renal, hepatic or cardiovascular disease. 2. Pregnant or lactating women. 3. Upper respiratory infection within 14 days of study start.

Locations (1)

University of Chicago

Chicago, Illinois, United States

Outcomes

Primary Outcomes

Change in ocular symptoms

Time frame: between days 1 and 3

Secondary Outcomes

number of eosinophils

Time frame: between days 1 and 3

Data from ClinicalTrials.gov

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