Topical Tazarotene in Treating Patients With Basal Cell Skin Cancer and Basal Cell Nevus Syndrome on the Face

List of Inclusion Criteria: 1. Study subjects must have at least one basal cell carcinoma ≥ 3mm in diameter (target lesion) on any area of the skin except the face, chest, and back (and not impinging on vital sites) diagnosed clinically by a Study Investigator at the baseline visit. 2. Study subjects must meet diagnostic criteria for basal cell nevus syndrome including major criterion #1 plus one additional major criterion or two of the minor criteria outlined in Table I. A first degree relative would satisfy BCNS diagnostic criteria with any two major criteria or any single major plus two minor criteria. Table I. BCNS Diagnostic Criteria Major criteria 1. More than 2 BCCs or one under the age of 20 years 2. Odontogenic keratocysts of the jaw proven by histology 3. Three or more palmar and/or plantar pits 4. Bilamellar calcification of the falx cerebri (if less than 20 years old) 5. Fused, bifid, or markedly splayed ribs. 6. First degree relative with basal cell nevus syndrome (BCNS) 7. PTCH1 gene mutation in normal tissue\* Minor criteria 1. Macrocephaly determined after adjustment for height 2. Congenital malformations: cleft lip or palate, frontal bossing, "coarse face." 3. Skeletal abnormalities: Sprengel deformity, marked pectus deformity 4. Radiological abnormalities: bridging of the sella turcica, vertebral anomalies such as hemivertebrae, fusion or elongation of the vertebral bodies. 5. Ovarian fibroma 6. Medulloblastoma 3.The subject is from 18-75 years of age, inclusive. 4\. If the subject is female and of child-bearing potential (women are considered not of childbearing potential if they are at least 2 years post-menopausal and/or surgically sterile), she: i. has been using adequate contraception (abstinence, IUD, birth control pills, or spermicidal gel with diaphragm or condom) since her last menses and will use adequate contraception during the study, and ii. is not lactating, and iii. has documented one negative serum pregnancy test within 14 days prior to study entry. 5\. The subject is willing to abstain from application of non-study topical medications to the skin of the face for the duration of the study, including prescription and over the counter preparations. 6\. The subject is willing not to have targeted BCCs treated by their PSCP unless the BCCs are documented by Study Investigators, preferably on two separate visits, except when the PSCP believes that delay in treatment potentially might compromise the health of the subject. List of Exclusion Criteria: 1. The subject has used topical or systemic therapies that might interfere with the evaluation of the study medication during the study. 2. The subject has a history of hypersensitivity to any of the ingredients in the study medication formulations. 3. The subject is unable to return for follow-up tests. 4. The subject has uncontrolled systemic disease, including known HIV positive patients. 5. The subject has a history of other skin conditions or significant illness that would interfere with evaluation of the study medication. 6. Any condition or situation which in the Investigator's opinion may put the subject at significant risk, could confound the study results, or could interfere significantly with the subject's participation in the study. 7. The subject has a history of invasive cancer within the past five years excluding non-melanoma skin cancer, Stage I cervical cancer, or CLL Stage 0.