Naproxen for the Prevention of HO After Complex Elbow Trauma

Inclusion Criteria: 1. Subjects aged 18 years or greater 2. Operative treatment of one of the following injuries * An elbow dislocation with or without associated fractures * An olecranon fracture-dislocation, but not simple olecranon fractures * A distal humerus fracture Exclusion Criteria: 1. An existing diagnosis of one of the following conditions * Injury to the central nervous system, thorax, or abdomen precluding the immediate use of non-steroidal anti-inflammatory medications * Fracture of any long bone since non-steroidal anti-inflammatory medications may increase the risk of nonunion * History of gastritis, peptic ulcer disease, or upper gastrointestinal bleeding * Impaired renal function (creatinine \> 2.0), hypovolemia, heart failure, high blood pressure ( \> 160/90), fluid retention, asthma, liver dysfunction (bilirubin \> 2.0), or a coagulation disorder * Allergy to non-steroidal anti-inflammatory medications * Asthma, nasal polyps, urticaria, and hypotension associated with the use of NSAIDs * Considerable dehydration 2. Pregnant or breast-feeding women 3. Concomitant use of one of the following drugs: * Aspirin * Other naproxen products (ec-naprosyn, anaprox, anaprox ds, naprosyn suspension, aleve) * Methotrexate * Diuretics (thiazides / furosemide) * ACE-inhibitors (captopril, enalapril, ramipril etc.) * Beta-blockers (propanolol etc.) * Probenecid (for gout or hyperuricemia) * H2-blockers, sucralfate and intensive antacid therapy * Lithium * Anticoagulants / Warfarin (coumadin, waran, jantoven etc.) * Sulfonamides * Anticonvulsant medication (peganone, mesantoin, cerebyx, dilantin, etc.)