The purpose of this study is to assess the efficacy of Eszopiclone in improving short and intermediate-term compliance with continuous positive airway pressure (CPAP) in patients newly diagnosed with obstructive sleep apnea (OSA).
CPAP is the treatment of choice for patients with OSA. However, patients are frequently intolerant of this therapy initially. After continued use, tolerance is achieved. However, this initial discomfort or intolerance frequently leads to a patient-initiated discontinuation of therapy. It has been shown that CPAP use at 1 month predicts use at 6 months and 1 year. Patients who initially struggle with or are intolerant of CPAP frequently abandon therapy and are unlikely to use it long term. To prevent this, sleep physicians often prescribe short courses of sedatives to help improve initial tolerance and promote better compliance with therapy. However, the effectiveness of this practice has not been validated in a clinical trial. Compliance, in reference to this study is the willingness of the patients to follow the prescribed course of treatment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE
Enrollment
154
Eszopiclone 3mg orally at bedtime for 14 nights
Matching placebo
Walter Reed Army Medical Center
Washington D.C., District of Columbia, United States
Short term CPAP Compliance
Time frame: 3 months
Intermediate CPAP Compliance
Time frame: 1 year
Quality of Life Issue - Prostate Symptoms for men
Time frame: 1 month, 3 months, 6 months, 9 months, 12 months
Quality of Life Issue - Erectile Dysfunction for men
Time frame: 1 month, 3 months, 6 months, 9 months, 12 months
Quality of Life Issue - Sleepiness
Time frame: 1 month, 3 months, 6 months, 9 months, 12 months
Quality of Life Issue - Fatigue
Time frame: 1 month, 3 months, 6 months, 9 months, 12 months
Quality of Life Issue - Subjective Sleep Quality
Time frame: 1 month, 3 months, 6 months, 9 months, 12 months
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