Salicylic Acid Peels Combined With 4% Hydroquinone in the Treatment of Moderate to Severe Melasma in Hispanic Women

University of Texas Southwestern Medical Center20 enrolled

Overview

This study will enroll 20 adult Hispanic women. Participants will apply 4% hydroquinone cream twice daily to affected areas on the face for 14 weeks and half the face will be peeled with 20-30% salicylic acid every two weeks for a total of 4 peels. The first two peels will be 20% salicylic acid and the second two peels will be with 30% salicylic acid. The purpose of the study will be to evaluate the safety and efficacy of salicylic acid combined with 4% hydroquinone versus 4% hydroquinone alone.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Melasma

Interventions

20-30% Salicylic Acid peels to the right side of the face

Two 20% salicylic acid peels two weeks apart followed by 2 30% salicylic acid peels two weeks apart to the right side of the face.

20-30% Salicylic Acid peels to the left side of the faceDRUG

Two 20% salicylic acid peels two weeks apart followed by 2 30% salicylic acid peels two weeks apart to the left side of the face

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Hispanic women ages 18-65 years of age with moderate to severe melasma * English and Spanish-speaking women Exclusion Criteria: * Pregnant or breast-feeding women * Subjects who have used 4% hydroquinone within 3 months of study start * Subjects who have used chemical peels, microdermabrasion or facial laser treatments within 9 months of study start

Locations (1)

UT Southwestern Medical Center at Dallas - Dermatology Clinical Trials

Dallas, Texas, United States

Outcomes

Primary Outcomes

Number of Participants Showing Improvement of Melasma Based on Mexameter Readings

Improvement of melasma on the peel side using mexameter reading

Time frame: 14 weeks

Data from ClinicalTrials.gov

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