Randomized, Controlled, Double Blind Trial of Eszopiclone for Insomnia Associated With Schizophrenia

Inclusion Criteria: * Be between the ages of 18 to 64 * Meet DSM-IV criteria for schizophrenia or schizoaffective disorder * Sleep difficulties at least 2x per week in the preceding month * Be on a stable dose of antipsychotic medication * Symptomatically stable in the last 2 months * English speaking. Exclusion Criteria: * Meet criteria for current alcohol or other substance dependence * A history of dementia, mental retardation or other neurological disorder * Not capable of giving informed consent for participation in this study. * Ongoing pregnancy * Known sensitivity to zopiclone. * Insomnia associated with medical disorders likely to impair sleep. * Use of any medication that affects sleep/wake function (other than antipsychotic medication), within the past 2 weeks or within a time period that is less than 7 half-lives since last use of the medication. * Lack of sleep benefit from previous adequate eszopiclone treatment * History of clinically significant hepatic impairment. * Subject is taking a potent cytochrome p450 3A4 inhibitor medication (ritonavir, nelfinavir, indinavir, erythromycin, clarithromycin, troleandomycin, ketoconazole, itraconazole) and is unwilling or it is clinically contraindicated to stop the medication.