Absorption, Distribution, Metabolism and Excretion (ADME) Study of TKI258 in Patients With Advanced Solid Malignancies

Inclusion criteria: 1. Aged ≥ 18 years 2. Patients with histologically confirmed solid tumor or lymphoma who are resistant/refractory to approved therapies or for whom no appropriate therapies are available. 3. WHO performance status ≤ 2 4. All previous treatment (including surgery and radiotherapy) must have been completed at least four weeks prior to study entry and any acute toxicities must have been resolved 5. Written informed consent to participate in the study Exclusion criteria: 1. Primary Brain Tumors or symptomatic leptomeningeal metastases 2. Clinically significant cardiac impairment or unstable ischemic heart disease including a myocardial infarction within six months of study start 3. Fertile males not willing to use contraception or whose female partners are not using adequate contraceptive protection Pregnant or lactating women (all women of childbearing potential must have a negative pregnancy test (\> 5 mIU/ml) before inclusion in the study; post-menopausal women must be amenorrheic for at least 12 months). Female patients must use adequate contraceptive protection 4. Centrally located or squamous cell carcinoma of the lung 5. Proteinuria \> 1+ on dipstick testing 6. History of gastrointestinal malabsorption Surgery involving intestinal anastomosis within four weeks of study start. Other protocol-defined inclusion/exclusion criteria may apply.