We want to evaluate the utility of statins on heart function according to potency. Patients with chronic ischemic heart failure are administered pitavastatin 4mg or pravastatin 10mg for 52 weeks. Then we evaluate the effect of pitavastatin and pravastatin primarily on rate of hospitalization for cardiovascular cause and lipid profile secondarily biomarker, echocardiography parameter, 6-minute walk, change of NYHA class distribution, cardiovascular mortality.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
70
pitavastatin 4mg once daily
pravastatin 10mg once daily
SEOUL St. Mary's Hospital
Seoul, Seocho-Ku, South Korea
Rate and number of hospitalization for cardiovascular cause; Lipid profile
Time frame: 52week
Biomarker : BNP, hsCRP, IL-6. TNF-α
Time frame: 52 week
Echocardiography : LVEF, E/A ratio, LVEDD, LVESD
Time frame: 52 week
Cardiac function evaluation (NYHA class distribution, 6-minute walk test)
Time frame: 52 week
Cardiovascular mortality
Time frame: 52 week
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.