Role of AT1-receptor Blockers in Insulin-induced Vasodilation.

N/AUnknownNCT00742066

Maastricht University Medical Center32 enrolled

Overview

In this study we hypothesize that blocking the angiotensin II AT1-receptor improves the insulin-induced microvascular dilatation. Objectives: 1. Does blockade of the angiotensin II AT1-receptor improve the insulin-induced microvascular effects in hypertensive patients. 2. Does blockade of the angiotensin II AT1-receptor impair the insulin-induced microvascular effects in normotensive control subjects?

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Hypertension Insulin Resistance Microcirculation

Interventions

IrbesartanDRUG

Single dose 600mg orally

FelodipineDRUG

single dose 10mg Felodipine ER

PlaceboDRUG

Single dose tablet orally

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: hypertensive subjects: 1. 18-60 years 2. Caucasian 3. untreated hypertension \>140/90mmHg. normotensive subjects: 1. 18-60 years 2. Caucasian 3. Blood pressure \<140/90 mmHg. Exclusion Criteria: 1. Obesity (BMI\>27kg/m2) 2. Cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, heart failure) 3. Impaired glucose tolerance or diabetes mellitus according to the criteria of the ADA 4. Smoking 5. Alcohol use \>4U/day 6. Use of medication (antihypertensive drugs, lipid lowering drugs, corticosteroids, NNSAIDs) 7. Pregnancy 8. Wearing contact lenses

Locations (1)

University Hospital Maastricht

Maastricht, P.O. Box 5800, Netherlands

Outcomes

Primary Outcomes

functional recruitment of capillaries in the skin

Time frame: July 2009

Secondary Outcomes

perfused capillary density in the nailfold

Time frame: July 2009

Endothelium- (in)dependent vasodilatation of finger skin microcirculation

Time frame: July 2009

Density of arterioles, capillaries and venules in the bulbar conjunctiva.

Time frame: July 2009

Diameter of arterioles and venules in the bulbar conjunctiva

Time frame: July 2009

Data from ClinicalTrials.gov

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