Visceral Pain From the Upper Urinary Tract - a Trial on the Effect of Morphine and Oxycodone in Patients Undergoing PCNL

Katja venborg Pedersen55 enrolled

Overview

The purpose of this study is to investigate the effect of oxynorm versus morphine after operation for kidney stone (PCNL). In addition the relationship between pain symptoms and referred sensory and trophic changes will be examined in the patients before and after the operation.Finally a blood sample is analysed to investigate pharmaca-genetics.

Primary outcome: the amount of opioid (morphine or oxynorm) used the first 4 hours postoperatively. Secondary outcome: side effect to the opioids, pain score, pain threshold to electrical stimulation and pressure before and after operation, pharmacogenetics, size of referred pain area.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Kidney Stones

Interventions

oxycodoneDRUG

intravenous according to patients weight, pn.

morphineDRUG

intravenous administration according to patients weight, pn.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age \> 18 * Indication for PCNL Exclusion Criteria: * Malignant disease in the upper urinary tract * Allergy to morphine or oxycodone * Use of opioids the last 48 hours before PCNL * Pregnancy * Nursing mothers * Present JJ-stent in the ureter * Previous urinary stone disease on the opposite site

Locations (1)

Hospital Little Belt, Fredericia

Fredericia, Denmark

Outcomes

Primary Outcomes

Amount of analgetics used

Time frame: four hours postoperatively

Secondary Outcomes

Side effects

Time frame: four hours postoperatively

Data from ClinicalTrials.gov

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